Results 71 to 80 of about 3,602,068 (194)

MRI-based skeletal hand movement model [PDF]

, 2012
The kinematics of the human hand is optimal with respect to force distribution during pinch as well as power grasp, reducing the tissue strain when exerting forces through opposing fingers and optimising contact faces.
Hillenbrand, Ulrich, Stillfried, Georg, Ulrich Hillenbrand, Patrick van der Smagt, Marcus Settles, Georg Stillfried, Settles, Marcus, van der Smagt, Patrick   +7 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Assessment of hand-grip and key-pinch strength at three arm positions among healthy college students: Dominant versus non-dominant hand

Journal of Taibah University Medical Sciences, 2019
الملخص: أهداف البحث: إن قوة القبضة مهمة للاستقلال بالرعاية الذاتية ومؤشر على الانخفاض الوظيفي. هدفت هذه الدراسة إلى تحديد ما إذا كان الأفراد الأصحاء سيظهرون قبضة لليد وقوة قرصة مختلفة: أولا، عند اختبارهما في ثلاثة أوضاع مختلفة للذراع؛ وثانيا، عند ...
Tarek M. El-gohary, PhD, Samiha M. Abd Elkader, PhD, Abdullah M. Al-shenqiti, PhD, Mahmoud I. Ibrahim, PhD   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Mean hand grip strength of the dominant hand in males and females.

, 2018
Mean hand grip strength of the dominant hand in males and females.
Woo Ram Koo (5071628), Chung Reen Kim (5071619), Young-Jee Jeon (5071631), Taeheum Jeong (5071625), Moon Chan Kim (5071622)   +4 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Cerebral haemodynamics during motor imagery of self-feeding with chopsticks: differences between dominant and non-dominant hand

, 2019
Purpose: Motor imagery is defined as a dynamic state during which a subject mentally simulates a given action without overt movements. Our aim was to use near-infrared spectroscopy to investigate differences in cerebral haemodynamics during motor imagery
Naoki Iso (670656), Takefumi Moriuchi (670655), Goro Tanaka (8101925), Sumihisa Honda (4006787), Toshio Higashi (670661), Kengo Fujiwara (8101922), Moemi Matsuo (8101919), Daiki Matsuda (236667)   +7 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source