Results 81 to 90 of about 2,633,621 (286)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Can Long-Term Regular Practice of Physical Exercises Including Taichi Improve Finger Tapping of Patients Presenting With Mild Cognitive Impairment?

Frontiers in Physiology, 2018
Background: Mild cognitive impairment (MCI) is a brain disease with both anatomical and functional alterations. There is clear evidence that individuals that are diagnosed with MCI have a high risk to develop dementia in the next 2–5 years compared to an
Lingli Zhang, Yilong Zhao, Chao Shen, Le Lei, Junjie Dong, Dongchen Zou, Jun Zou, Miao Wang   +7 more
doaj   +1 more source

Supporting SPARQL Update Queries in RDF-XML Integration [PDF]

, 2014
The Web of Data encourages organizations and companies to publish their data according to the Linked Data practices and offer SPARQL endpoints. On the other hand, the dominant standard for information exchange is XML.
Bikakis, Nikos, Christodoulakis, Stavros, Stavrakantonakis, Ioannis, Tsinaraki, Chrisa   +3 more
core  

Prefrontal involvement in imitation learning of hand actions : effects of practice and expertise. [PDF]

, 2007
In this event-related fMRI study, we demonstrate the effects of a single session of practising configural hand actions (guitar chords) on cortical activations during observation, motor preparation, and imitative execution.
Buccino, Giovanni, Canessa, Nicola, Eickhoff, Simon B., Fink, Gereon R., Freund, Hans-Joachim, Rizzolatti, Giacomo, Shah, N. Jon, Vogt, Stefan, Wohlschläger, Afra M., Zilles, Karl   +9 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Analyzing Grip Strength Disparities Between Dominant and Non-Dominant Hands: Influence of Sex and Age in the Polish Population

Applied Sciences
Handgrip strength (HGS) is a key indicator of muscular fitness and physical health. Recently, attention has focused on HGS asymmetry as a potential marker of functional impairment.
Hanna Zadoń, Katarzyna Nowakowska-Lipiec, Maria Filipek, Irmina Lepiarczyk, Aleksandra Matusiak, Anna Piechnik, Wojciech Pieniążek, Zofia Piejak, Martyna Przybylska, Maria Zadoń, Piotr Szaflik   +10 more
doaj   +1 more source

Forward modeling of emission in SDO/AIA passbands from dynamic 3D simulations

, 2017
It is typically assumed that emission in the passbands of the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO) is dominated by single or several strong lines from ions that under equilibrium conditions are formed in a ...
Aschwanden, Bart De Pontieu, De Pontieu, Feldman, Feldman, Foster & Testa, Gudiksen, Hansteen, Hansteen, Hansteen, Heggland, Juan Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Paola Testa, Rouppe van der Voort, Schmelz, Testa, Viggo Hansteen   +21 more
core   +1 more source

Leptogenesis with single right-handed neutrino dominance [PDF]

Physical Review D, 2001
Considerably improved calculation of $Y_B$ based on a new fit to Boltzmann equations, strengthening the ...
Hirsch, M., King, S.F.
openaire   +4 more sources