Results 61 to 70 of about 46,459 (294)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
A note on global alliances in trees [PDF]
Opuscula Mathematica, 2011 For a graph \(G=(V,E)\), a set \(S\subseteq V\) is a dominating set if every vertex in \(V-S\) has at least a neighbor in \(S\). A dominating set \(S\) is a global offensive (respectively, defensive) alliance if for each vertex in \(V-S\) (respectively ...
Mohamed Bouzefrane, Mustapha Chellali
doaj +1 more source
Domination and Fractional Domination in Digraphs
The Electronic Journal of Combinatorics, 2018 In this paper, we investigate the relation between the (fractional) domination number of a digraph $G$ and the independence number of its underlying graph, denoted by $\alpha(G)$. More precisely, we prove that every digraph $G$ on $n$ vertices has fractional domination number at most $2\alpha(G)$ and domination number at most $2\alpha(G) \cdot \log{n}$.
Harutyunyan, Ararat +3 more
openaire +5 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
E-Spania, 2013 Les océans ont longtemps représenté des espaces de frontière. À partir du XVIe siècle cependant, ils deviennent des vecteurs de communication et permettent de relier toutes les parties du monde entre elles et notamment Rome, alors considérée comme le ...
Delphine Tempère
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Independent domination in the graph defined by two consecutive levels of the $n$-cube [PDF]
, 2023 Thomas Kalinowski, Uwe Leck
openalex +1 more source