Results 81 to 90 of about 44,708 (295)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Journal of Deliberative Democracy, 2019 Both advocates and critics of deliberative theory have regarded power relations as problems for public deliberation. Three aspects—interests, ideology and status differences—have been thought to distort deliberative processes.
Markus Holdo
doaj +2 more sources
Independent domination in the graph defined by two consecutive levels of the $n$-cube [PDF]
, 2023 Thomas Kalinowski, Uwe Leck
openalex +1 more source
Operations Research Letters, 2004 This paper presents several representation theorems for the solubility of three cost allocation problems, which are presented as cooperative games. In each problem, a graph \(G = (V, E)\) is given along with a cost function: given \(S \subseteq V\), \(c(S)\) is the cost of \(k\)-dominating the vertices in \(S\), i.e., building a set \(K \subseteq V ...
openaire +5 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
A Conversation with Archbishop Desmond Tutu: Leaders Transforming Cultures
Interdisciplinary Journal of Partnership Studies, 2015 Riane Eisler talks with Nobel laureate Archbishop Desmond Tutu about transforming cultures from domination to partnership and progress in this direction, including changing traditions of violence against women and children, gender equality, and the role ...
Riane Eisler
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Nonsplit Neighbourhood Tree Domination Number In Connected Graphs
, 2021 Et. al. S. Muthammai
openalex +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Theories and Dimensions of Algorithmic Power, between Agency and Domination
Scienza & PoliticaThis article reviews the critical and sociological literature on algorithms and AI in light of anthropocentric social theories of power and its dimensions.
Massimo Airoldi
doaj +1 more source