Results 131 to 140 of about 17,770 (310)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Domination in Graph Theory: A Bibliometric Analysis of Research Trends, Collaboration and Citation Networks [PDF]

open access: green
Jonecis Dayap   +4 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

VERBALIZATION OF INFORMATIONAL MODEL «CHINA’S DOMINATION» IN THE U.S. MASS-MEDIA

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2013
The article is devoted to the research of informational model verbalization titled «China’s Domination», which is formed by the USA mass media. The applicability of this theme is proved by importance of national cognitive activity research (informational
Olga Nikolayevna Sorokina
doaj  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Graphical Dominance Analysis for Linear Systems: A Frequency-Domain Approach

open access: yes
We propose a frequency-domain approach to dominance analysis for multi-input multi-output (MIMO) linear time-invariant systems. The dominance of a MIMO system is defined to be the number of its poles in the open right half-plane. Our approach is graphical: we define a frequency-wise notion of the recently-introduced scaled graph of a MIMO system ...
Chen, Chao   +2 more
openaire   +3 more sources

Home - About - Disclaimer - Privacy