Results 81 to 90 of about 16,376 (310)

Violence and the Imaginary: Some Reflections on and around the Occupy Movement

open access: yesIm@go. A Journal of the Social Imaginary, 2014
Starting from the idea that we can distinguish between two main types of the imaginary – the retrograde imaginary and the imaginary of liberation, and following Michel Foucault’s distinction between dialectic and strategic logic, this essay seeks to ...
Bruno Gullì
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Mary Shelley Biopic (2017): A filmic discourse analysis

open access: yesCINEJ Cinema Journal
This work analyzes the discourses that compound Mary Shelley biopic (2017), concerning male domination and female resistance. To do so, the specific objectives are: to verify how this domination permeates the main character with a view to publish her ...
Thanya Araujo, Lívia Fernanda Silva
doaj   +1 more source

Stochastic dominance analysis of CTA funds

open access: yesReview of Quantitative Finance and Accounting, 2012
In this paper, we employ the stochastic dominance (SD) approach to rank the performance of commodity trading advisors (CTA) funds. An advantage of this approach is that it alleviates the problems that can arise if CTA returns are not normally distributed by utilizing the entire returns distribution.
LEAN, Hooi Hooi   +2 more
openaire   +4 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

O GRUPO LEMANN E O NOVO PAPEL DOS APARELHOS PRIVADOS DE HEGEMONIA NO CAMPO DA EDUCAÇÃO NO BRASIL

open access: yesRevista Trabalho, Política e Sociedade, 2019
The article analyzes the performance of the Lemann Group which, through the Lemann Foundation, has been acting on several fronts of the public education policy in Brazil.
Maria Teresa Cavalcanti de Oliveira
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

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