Results 121 to 130 of about 1,607 (170)

Domoic acid in Portuguese shellfish and fish

Toxicon, 2001
The presence of domoic acid (DA) in Portuguese shellfish is a recurrent event that affects shellfish resources several times a year, mainly in spring and autumn. Levels of domoic acid as high as twice the regulatory level of 20 microg DA/g tissue are not unusual.
Paulo Vale
exaly   +3 more sources

Polyclonal antibodies to domoic acid, and their use in immunoassays for domoic acid in sea water and shellfish

Natural Toxins, 1998
Ovine antibodies raised against conjugates linked through the secondary amino group of domoic acid (1) were used, together with activated-ester-derived conjugates of domoic acid (DA) as the plate coater, to develop a robust indirect competitive enzyme-linked immunosorbent assay (cELISA) for DA in shellfish and seawater.
Ian Garthwaite   +2 more
exaly   +3 more sources

Domoic Acid

2014
Domoic acid (DA) was of no special scientific interest until a series of case studies revealed its role as the major marine neurotoxin causing amnesic shellfish poisoning (ASP). The analysis, toxicology, synthesis and degradation of the highly polar amino acid DA and its kainoid congeners are discussed in this chapter.
L.G. Costa, G. Giordano, M. Aschner
openaire   +3 more sources

Perinatal Domoic Acid as a Neuroteratogen

2015
In mammals, the period shortly before and shortly after birth is a time of massive brain growth, plasticity and maturation. It is also a time when the developing brain is exquisitely sensitive to insult, often with long-lasting consequences. Many of society's most debilitating neurological diseases arise, at least in part, from trauma around the time ...
Tracy A, Doucette, R Andrew, Tasker
openaire   +2 more sources

Chemistry of Domoic Acid, Isodomoic Acids, and Their Analogues

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Clayden, Jonathan   +2 more
openaire   +2 more sources

Toxicology and seafood toxins: Domoic acid

Natural Toxins, 1994
AbstractMarine and terrestrial food sources are susceptible to contamination by various industrial chemicals and microbial pathogens. Both types of hazard are amenable to regulatory assessment using a single toxicology data base, along with some knowledge of contaminant levels and consumption figures for food.
F, Iverson, J, Truelove
openaire   +2 more sources

Renal clearance of domoic acid in the rat

Food and Chemical Toxicology, 1993
The renal clearance (Clr) of the seafood toxin domoic acid (DA) was investigated in the rat. Following cannulation of the right femoral artery, the left femoral vein and the bladder of anaesthetized rats, a single bolus injection of either [3H]DA, [14C]p-aminohippuric acid (PAH) or [3H]inulin was administered through the venous cannula.
C A, Suzuki, S L, Hierlihy
openaire   +2 more sources

Acute Neurotoxicity of Domoic Acid in the Rat

Toxicologic Pathology, 1990
A recent outbreak of human food poisoning, characterized by severe gastrointestinal and neurologic abnormalities, with a fatal outcome in 3 patients, was attributed to the consumption of poisonous mussels containing domoic acid at an abnormally high concentration.
L, Tryphonas   +3 more
openaire   +2 more sources

Toxicokinetics of domoic acid in the fetal rat

Toxicology, 2012
Domoic acid (DA) is a potent neurotoxin that has both marine wildlife and human health impacts, including developmental effects during prenatal exposure in rodent models. However, little is known regarding DA toxicokinetics in the fetal unit during maternal-fetal transfer.
Jennifer, Maucher Fuquay   +3 more
openaire   +2 more sources

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