Results 31 to 40 of about 6,252 (211)

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources

Monitoring of freshwater toxins in European environmental waters by using novel multi-detection methods [PDF]

, 2017
Monitoring the quality of freshwater is an important issue for public health. In the context of the European project μAqua, 150 samples were collected from several waters in France, Germany, Ireland, Italy, and Turkey for 2 yr.
Ajani, Banker, Burch, Campbell, Chen, Chislock, Cires, Clayden, Devlin, Elliott, Eriksson, Fraga, Fraga, Fraga, Frank, Hansen, Hansen, Heath, Hilborn, James, James, Kim, Kotaki, Lopez-Alonso, Lévesque, Mann, Marcheggiani, McGrath, Mejean, Merel, Merel, Metcalf, Moreira, Moreira, Norris, Osswald, Pearson, Pereira, Quiblier, Rodriguez, Rodriguez, Sanchez, Slevin, Spivak, Stevens, Terao, Thomas, Trainer, Triantis, Usleber, Viaggiu, Wonnacott   +51 more
core   +1 more source

Aerosolizable marine phycotoxins and human health effects : in vitro support for the biogenics hypothesis [PDF]

, 2020
Respiratory exposure to marine phycotoxins is of increasing concern. Inhalation of sea spray aerosols (SSAs), during harmful Karenia brevis and Ostreopsis ovata blooms induces respiratory distress among others. The biogenics hypothesis, however, suggests
Asselman, Jana, Beck, Ilse, De Rijcke, Maarten, De Schamphelaere, Karel, Huysman, Steve, Janssen, Colin, Van Acker, Emmanuel, Vanhaecke, Lynn   +7 more
core   +1 more source

A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity. [PDF]

PLoS ONE, 2012
The neurotoxic amino acid, domoic acid (DA), is naturally produced by marine phytoplankton and presents a significant threat to the health of marine mammals, seabirds and humans via transfer of the toxin through the foodweb.
Kathi A Lefebvre, Elizabeth R Frame, Frances Gulland, John D Hansen, Preston S Kendrick, Richard P Beyer, Theo K Bammler, Frederico M Farin, Emma M Hiolski, Donald R Smith, David J Marcinek   +10 more
doaj   +1 more source

Nitrogenous nutrition of the potentially toxic diatom Pseudonitzschia pungens f. multiseries Hasle [PDF]

, 1996
The potentially toxic diatom Pseudonitzschia pungens f. multiseries was grown on different sources of nitrogen in batch cultures. Ammonium did not support growth at concentrations >200 μM, and even lowered the growth rate, when it was supplied in ...
Hillebrand, Helmut, Sommer, Ulrich
core   +1 more source

Harmful algal and cyanobacterial toxins in foraging green turtles (Chelonia mydas) in Florida's Big Bend

Toxicon: X, 2020
Numerous toxin-producing harmful algal (HAB) species occur in Florida's coastal waters. Exposure to these toxins has been shown to have sublethal effects in sea turtles.
Justin R. Perrault, Christopher R. Perkins, Matthew J. Ajemian, Michael J. Bresette, Cody R. Mott, Annie Page-Karjian   +5 more
doaj   +1 more source

Trajectory design for autonomous underwater vehicles based on ocean model predictions for feature tracking [PDF]

, 2010
Trajectory design for Autonomous Underwater Vehicles (AUVs) is of great importance to the oceanographic research community. Intelligent planning is required to maneuver a vehicle to high-valued locations for data collection.
Caron, David, Chao, Yi, Jones, Burton, Li, Peggy, Smith, Ryan, Sukhatme, Gaurav   +5 more
core   +2 more sources

RNA-Seq Transcriptome Profiling of the Queen Scallop (Aequipecten opercularis) Digestive Gland after Exposure to Domoic Acid-Producing Pseudo-nitzschia

Toxins, 2019
Some species of the genus Pseudo-nitzschia produce the toxin domoic acid, which causes amnesic shellfish poisoning (ASP). Given that bivalve mollusks are filter feeders, they can accumulate these toxins in their tissues.
Pablo Ventoso, Antonio J. Pazos, M. Luz Pérez-Parallé, Juan Blanco, Juan C. Triviño, José L. Sánchez   +5 more
doaj   +1 more source

Marine Excitatory Amino Acids: Structure, Properties, Biosynthesis and Recent Approaches to Their Syntheses

Molecules, 2020
This review considers the results of recent studies on marine excitatory amino acids, including kainic acid, domoic acid, dysiherbaine, and neodysiherbaine A, known as potent agonists of one of subtypes of glutamate receptors, the so-called kainate ...
Valentin A. Stonik, Inna V. Stonik
doaj   +1 more source

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

Neurobiology of Disease, 2012
Several studies have implicated the enzyme acetylcholinesterase (AChE) as well as several biometals in the pathogenesis of Alzheimer's disease (AD). A multifunctional molecule, the hybrid tacrine-8-hydroxyquinoline (named IQM-622), displays cholinergic ...
Desiree Antequera, Marta Bolos, Carlos Spuch, Consuelo Pascual, Isidro Ferrer, María Isabel Fernandez-Bachiller, María Isabel Rodríguez-Franco, Eva Carro   +7 more
doaj   +1 more source