Results 51 to 60 of about 13,668,831 (239)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Brain Stem Death and Organ Donation

, 1989
Organs for donation are in short supply in the United Kingdom, resulting in allegations that relatives of potential donors are not being asked for consent. Legislation on "required request" has been proposed to overcome this.
and Park, G.R., Berridge, J.C., Park, G.R., Bodenham, A.   +3 more
core   +1 more source

Family Interview for Brain Death and Tissue-organ Donation

, 2023
After brain death, a family interview is required to discuss organ donation requests and procedures with the donor’s relatives. This interview process requires knowledge, communication skills and experience for the interviewers.
Kerem Erkalp
core   +1 more source

Heart transplantation outcomes with donation after circulatory death in patients with left ventricular assist device

ESC Heart Failure
Aims Donation after circulatory death (DCD) has emerged as a strategy to increase the donor pool for heart transplantation (HT). Left ventricular assist device (LVAD) patients represent a discrete and unique population.
Aris Karatasakis, Edwin Grajeda Silvestri, Gatha G. Nair, Benjamin Zuniga, Song Li, Claudius Mahr, Richard K. Cheng, April S. Stempien‐Otero, Ioannis Dimarakis, Maziar Khorsandi, Jay D. Pal, Jorge R. Kizer, Marc A. Simon, Claudio A. Bravo   +13 more
doaj   +1 more source

Outcomes Following Donation After Brain Death and Donation After Circulatory Death Liver Transplantation in Patients with Primary Sclerosing Cholangitis

Transplantology
Background: Primary sclerosing cholangitis (PSC) accounts for 10–15% of liver transplants but is the leading cause of retransplant. This study evaluates whether PSC patients have different survival and graft outcomes when receiving grafts from donors ...
Kevin Verhoeff, Uzair Jogiat, Alessandro Parente, Blaire Anderson, Khaled Dajani, David L. Bigam, A. M. James Shapiro   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Deceased organ donation activity and efficiency in Switzerland between 2008 and 2017: achievements and future challenges

BMC Health Services Research, 2018
Background Various actions have been taken during the last decade to increase the number of organs from deceased donors available for transplantation in Switzerland.
Julius Weiss, Andreas Elmer, Markus Béchir, Christian Brunner, Philippe Eckert, Susann Endermann, Renato Lenherr, Mathias Nebiker, Kai Tisljar, Christoph Haberthür, Franz F. Immer, on behalf of the Comité National du Don d’Organes (CNDO)   +11 more
doaj   +1 more source

Causes of donation failure and improvement measures analyzed based on data from domestic deceased donors in 2019

Korean Journal of Transplantation, 2020
In 2019, 1,630 organs were recovered from 450 brain death donors nationwide and were transplanted into 1,612 transplant recipients. However, considering that the number of potential brain-dead linked to the Korea Organ Donation Agency (KODA) information ...
Won-Hyun Cho
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source