Results 101 to 110 of about 37,774 (258)

The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention

Frontiers in Aging Neuroscience
IntroductionDonepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD).
Ting Yang, Fuquan Wei, Yufei Guo, Mengxiao Zhu, Hongtao Hou, Zhongwei Guo, Xiaozheng Liu, Xiaozheng Liu   +7 more
doaj   +1 more source

Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes

Journal of Pharmacological Sciences, 2017
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. In the present study, we investigated the responses of astrocytes to bradykinin, an inflammatory mediator, and the effect of donepezil ...
Kouki Makitani, Shota Nakagawa, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume   +4 more
doaj   +1 more source

Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer's disease [PDF]

, 2008
Neuroimaging studies of cholinesterase inhibitor (ChEI) treatment in Alzheimer's disease (AD) indicate that the short and long term actions of ChEIs are dissimilar. fMRI studies of the ChEI rivastigmine have focused on its short term action.
McGeown, William J, Shanks, Michael F, Venneri, Annalena   +2 more
core   +2 more sources

Comparative effectiveness of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists for incident dementia: A retrospective multicohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1443-1452, February 2026.
Abstract Objective This study provides real‐world evidence on the comparative effectiveness of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) regarding the risk of incident dementia in adults with type 2 diabetes mellitus (T2DM).
Filippos Anagnostakis, Michail Kokkorakis, Shrihari Nagarajan, Georgia Anastasiou, Christos S. Mantzoros   +4 more
wiley   +1 more source

Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neuron of the CA1 Hippocampus in Rat Model of Alzheimer\'s Disease

Basic and Clinical Neuroscience, 2019
Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region ...
Azade Eskandary, Ahmad Ali Moazedi, Hossein Najaph Zade, Mohamad Reza Akhond   +3 more
doaj  

Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers

Drug Design, Development and Therapy, 2020
Seok Kyu Yoon,1 Kyun-Seop Bae,1 Dong Hyun Hong,2 Seong Su Kim,2 Young Kweon Choi,2 Hyeong-Seok Lim1 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea ...
Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS   +5 more
doaj  

No synergistic effect of subtherapeutic doses of donepezil and EVP‐6124 in healthy elderly subjects in a scopolamine challenge model

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction Donepezil is a widely used cholinesterase inhibitor in the management of Alzheimer's disease. Despite large‐scaled evidence for its efficacy, elevated peripheral ACh levels often lead to side effects and are dose limiting.
Anne Catrien Baakman, Ricardo Alvarez‐Jimenez, Gordon Loewen, Marieke L. deKam, Karen Broekhuizen, Dana C. Hilt, Geert Jan Groeneveld   +6 more
doaj   +1 more source

Donepezil Adherence, Persistence and Time to First Discontinuation in a Three-Year Follow-Up of Older People

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background: Donepezil is indicated for the management of mild to moderate dementia, particularly in Alzheimer's disease. Several studies have described low adherence rates with donepezil.
Henry C. Ndukwe, Prasad S. Nishtala
doaj   +1 more source

Effect of Psychoeducational Intervention on Donepezil Retention Rate and Analysis of Reasons for the Discontinuation in Patients with Alzheimer’s Dementia: A Randomized Study

Patient Preference and Adherence, 2021
Tetsumasa Kamei,1 Hiroyuki Kobayashi,2,3 Maika Nishida,2 Kenzo Muramoto,2 Shohei Nishimoto2 1Shonan Fujisawa Tokushukai Hospital, Kanagawa, Japan; 2Eisai Co., Ltd., Medical Headquarters, Tokyo, Japan; 3Department of Neuropsychiatry, School of Medicine ...
Kamei T, Kobayashi H, Nishida M, Muramoto K, Nishimoto S   +4 more
doaj  

Effects of Donepezil on Clinical Symptoms, Language, and Executive Skills in Individuals with Autism Spectrum Disorder: A Systematic Review [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. This study assessed the potential efficacy of donepezil in treating autism spectrum disorder (ASD), a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Donepezil, primarily used to treat
Shahrokh Amiri, Shadi Farabi Maleki, Leila Mandaloo, Morteza Ghojazadeh, Manouchehr Seyedi Vafaee   +4 more
doaj   +1 more source