Results 101 to 110 of about 33,626 (230)

Evaluation the effect of Donepezil on Cerebral Blood Flow Velocity in Alzheimer's Disease

مجله دانشکده پزشکی اصفهان, 2010
Background: The main cause of Alzheimer's disease (AD) is loss of cholinergic function. So, the choice strategy of therapy is to increase the level of acetylcholine (Ach) in the brain of by acetylcholinesterase inhibitors (AchEIs) such as Donepezil. This
Abbas Ghorbani, Ahmad Chitsaz, Mehdi Shishegar, Mojtaba Akbari   +3 more
doaj  

The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention

Frontiers in Aging Neuroscience
IntroductionDonepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD).
Ting Yang, Fuquan Wei, Yufei Guo, Mengxiao Zhu, Hongtao Hou, Zhongwei Guo, Xiaozheng Liu, Xiaozheng Liu   +7 more
doaj   +1 more source

Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes

Journal of Pharmacological Sciences, 2017
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. In the present study, we investigated the responses of astrocytes to bradykinin, an inflammatory mediator, and the effect of donepezil ...
Kouki Makitani, Shota Nakagawa, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume   +4 more
doaj   +1 more source

Major Adverse Cardiac Events with Ondansetron: A Systematic Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 905-915, April 2026.
Evidence base: 170 randomized trials, 23,421 adults, predominantly single‐dose IV ondansetron, mean follow‐up 20 days. Observed outcomes: Major adverse cardiac events were rare, no ventricular arrhythmias or torsades de pointes observed. Conclusion: Ondansetron was not associated with increased mortality or serious cardiac arrhythmias in adult ...
Michael Cristian Garcia, Bhavya Gandhi, Faisal Quadri, Mahnoor Shahab, Kassie Rong, Genevieve Ramnarine, Ishleen Sudan, Sophia Zhang, Michelle Yu, Sara Mojdehi, Lawrence Mbuagbaw, Anne M. Holbrook   +11 more
wiley   +1 more source

Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neuron of the CA1 Hippocampus in Rat Model of Alzheimer\'s Disease

Basic and Clinical Neuroscience, 2019
Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region ...
Azade Eskandary, Ahmad Ali Moazedi, Hossein Najaph Zade, Mohamad Reza Akhond   +3 more
doaj  

Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers

Drug Design, Development and Therapy, 2020
Seok Kyu Yoon,1 Kyun-Seop Bae,1 Dong Hyun Hong,2 Seong Su Kim,2 Young Kweon Choi,2 Hyeong-Seok Lim1 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea ...
Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS   +5 more
doaj  

No synergistic effect of subtherapeutic doses of donepezil and EVP‐6124 in healthy elderly subjects in a scopolamine challenge model

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction Donepezil is a widely used cholinesterase inhibitor in the management of Alzheimer's disease. Despite large‐scaled evidence for its efficacy, elevated peripheral ACh levels often lead to side effects and are dose limiting.
Anne Catrien Baakman, Ricardo Alvarez‐Jimenez, Gordon Loewen, Marieke L. deKam, Karen Broekhuizen, Dana C. Hilt, Geert Jan Groeneveld   +6 more
doaj   +1 more source

Donepezil Adherence, Persistence and Time to First Discontinuation in a Three-Year Follow-Up of Older People

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background: Donepezil is indicated for the management of mild to moderate dementia, particularly in Alzheimer's disease. Several studies have described low adherence rates with donepezil.
Henry C. Ndukwe, Prasad S. Nishtala
doaj   +1 more source

Cognitive dysfunction and dementia in Parkinson's disease [PDF]

, 2004
Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder mainly characterized by degeneration of dopaminergic neurons in the substantia nigra and the ventral tegmental area, in combination with a varying loss of central noradrenergic ...
Bosboom, JL, Stoffers, D., Wolters, E.C.M.J.   +2 more
core   +1 more source

Effects of Donepezil on Clinical Symptoms, Language, and Executive Skills in Individuals with Autism Spectrum Disorder: A Systematic Review [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. This study assessed the potential efficacy of donepezil in treating autism spectrum disorder (ASD), a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Donepezil, primarily used to treat
Shahrokh Amiri, Shadi Farabi Maleki, Leila Mandaloo, Morteza Ghojazadeh, Manouchehr Seyedi Vafaee   +4 more
doaj   +1 more source