Results 101 to 110 of about 28,065 (271)

Review: donepezil improves clinical state in mild or moderate Alzheimer's disease [PDF]

, 1999
James Warner
openalex   +1 more source

Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome

Annals of Clinical and Translational Neurology, 2019
De novo loss‐of‐function mutations in SCN1A are the main cause of Dravet syndrome, a catastrophic encephalopathy characterized by recurrent early‐life febrile seizures, a number of other afebrile seizure types that are often refractory to treatment, and ...
Jennifer C. Wong, Jacquelyn T. Thelin, A. Escayg   +2 more
semanticscholar   +1 more source

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia‐specific perspectives

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease‐modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment‐induced changes in ...
Takeshi Iwatsubo, Reisa A. Sperling, Alicia Algeciras‐Schimnich, Hidenori Arai, Anna M. Barron, Tammie L. S. Benzinger, Maria C. Carrillo, Christopher Chen, Seong Hye Choi, Igor C. Fontana, Jonathan Graff‐Radford, Joshua D. Grill, Judith Heidebrink, Chaur‐Jong Hu, Ryoko Ihara, Takeshi Ikeuchi, Atsushi Iwata, Fanny C. F. Ip, Fasihah Irfani Fitri, Clifford R. Jack Jr., Jee Hyang Jeong, Jianping Jia, Nagaendran Kandiah, SangYun Kim, Hisatomo Kowa, Renaud La Joie, Yoshiki Niimi, Ryoji Noritake, Ozioma C. Okonkwo, Sebastian Palmqvist, Michael S. Rafii, Rema Raman, Yong Shen, Tanya Simuni, Heather M. Snyder, Orapitchaya Sriwannopas, Luke E. Stoeckel, Wiesje M. van der Flier, Huali Wang, Donna M. Wilcock, Henrik Zetterberg, Jin Zhou, Simin Mahinrad, Claire E. Sexton   +43 more
wiley   +1 more source

Effects of manual acupuncture combined with donepezil in a mouse model of Alzheimer’s disease

Acupuncture in Medicine, 2019
Objectives: To explore whether combined therapy with donepezil and acupuncture is better than treatment with donepezil or acupuncture individually in a rat model of Alzheimer’s disease.
Jing Jiang, Gang Liu, Suhua Shi, Yujie Li, Zhigang Li   +4 more
semanticscholar   +1 more source

Humility and Medicine, Lessons Learned: Perhaps the Fifth Ethics Principle

Journal of the American Geriatrics Society, EarlyView.
Michael Gordon
wiley   +1 more source

Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development

MedComm, Volume 6, Issue 8, August 2025.
Artificial intelligence is reshaping drug discovery by enhancing molecular design, target engagement, and therapeutic delivery with unprecedented precision and efficiency. This review summarizes recent advances in AI‐driven approaches across small molecule design, protein binder development, antibody engineering, and nanoparticle‐based delivery systems,
Yuan‐Tao Liu, Le‐Le Zhang, Zi‐Ying Jiang, Xian‐Shu Tian, Peng‐Lin Li, Pei‐Huang Wu, Wen‐Ting Du, Bo‐Yu Yuan, Chu Xie, Guo‐Long Bu, Lan‐Yi Zhong, Yan‐Lin Yang, Ting Li, Mu‐Sheng Zeng, Cong Sun   +14 more
wiley   +1 more source

Effect of Psychoeducational Intervention on Donepezil Retention Rate and Analysis of Reasons for the Discontinuation in Patients with Alzheimer’s Dementia: A Randomized Study

Patient Preference and Adherence, 2021
Tetsumasa Kamei,1 Hiroyuki Kobayashi,2,3 Maika Nishida,2 Kenzo Muramoto,2 Shohei Nishimoto2 1Shonan Fujisawa Tokushukai Hospital, Kanagawa, Japan; 2Eisai Co., Ltd., Medical Headquarters, Tokyo, Japan; 3Department of Neuropsychiatry, School of Medicine ...
Kamei T, Kobayashi H, Nishida M, Muramoto K, Nishimoto S   +4 more
doaj  

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Comparison of In Silico AChE Inhibitory Potentials of Some Donepezil Analogues

Pharmata
Cholinesterases are important in ensuring hemostasis in our body. Excessive increase in cholinesterase function causes various cholinergic dysfunctions. Alzheimer's is a disease characterized by loss of cholinergic activity, which is especially common in
Mehmet Koca
doaj  

Histological Protection by Donepezil Against Neurodegeneration Induced by Ischemia–Reperfusion in the Rat Retina

Journal of Pharmacological Sciences, 2010
Although a blockade of acetylcholine esterase has been reported to suppress neuronal cell death induced by exogenous glutamate and β-amyloid, information is still limited regarding the neuroprotective effects of the acetylcholine esterase inhibitor ...
Kenji Sakamoto, Kayo Ohki, Maki Saito, Tsutomu Nakahara, Kunio Ishii   +4 more
doaj