Results 91 to 100 of about 150,076 (297)
Advanced Science, EarlyView.An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong +14 more
wiley +1 more source
Siliao yanjiu, 2021 The experiment compares and analyzes the difference of blood and hair mineral element concentration between Dezhou black-head donkey and three-pink donkey.
Shao-bo ZHANG +7 more
doaj
Advanced Science, EarlyView.Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji +13 more
wiley +1 more source
Ultrasound‐Actuated Gene Editing in Human Kidney Organoids
Advanced Science, EarlyView.Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller +6 more
wiley +1 more source
Advanced Science, EarlyView.In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen +19 more
wiley +1 more source
An inland voyage : Travels with a donkey ; Edinburgh.
, 1909 An inland voyage -- Travels with a donkey -- Edinburgh.Mode of access ...
Stevenson, Robert Louis, 1850-1894. +2 more
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The Journal of Thoracic and Cardiovascular Surgery, 2017 Joanna, Chikwe, David H, Adams
openaire +2 more sources
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
, 1956 donkey[A game played with cards] The object is to get rid of your cards, and the man left with a card at the end is the donkey or jackass.PRINTED ITEM G.M.Story April 1956Used I and SupUsed I and ...
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Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source