Results 91 to 100 of about 141,307 (252)

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Advances in the Regulation of Lipid Metabolism by Non-Coding RNAs

Animals
Lipid metabolism is a fundamental biological process that ensures energy homeostasis and cellular integrity. This is an essential and complex biochemical process that is involved in energy storage and the maintaining of normal biological functions ...
Yongdong Peng, Anqi Liu, Qifei Zhu, Xiaotong Liu, Bingbing Cai, Zhiyu Yan, Jiwei Gao, Ruchang Zhu, Changfa Wang   +8 more
doaj   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

Gut microbiome regulation in equine animals: current understanding and future perspectives

Frontiers in Microbiology
The equine intestinal microbiome represents a complex and dynamic ecosystem that fundamentally influences host health and physiological function.
Fenglin Li, Xiangyu Kong, Muhammad Zahoor Khan, Lin Wei, Jinjin Wei, Mingxia Zhu, Guiqin Liu, Bingjian Huang, Changfa Wang, Zhenwei Zhang   +9 more
doaj   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Determinant genetic markers of semen quality in livestock

Frontiers in Endocrinology
The reproductive efficiency of livestock is crucial for agricultural productivity and economic sustainability. One critical factor in successful fertilization and the viability of offspring is the quality of semen.
Muhammad Zahoor Khan, Wenting Chen, Saima Naz, Xiaotong Liu, Huili Liang, Yinghui Chen, Xiyan Kou, Yihong Liu, Iqra Ashraf, Ying Han, Yongdong Peng, Changfa Wang, Muhammad Zahoor   +12 more
doaj   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Bioactive Compounds and Probiotics Mitigate Mastitis by Targeting NF-κB Signaling Pathway

Biomolecules
Mastitis is a significant inflammatory condition of the mammary gland in dairy cows. It is caused by bacterial infections and leads to substantial economic losses worldwide.
Muhammad Zahoor Khan, Liangliang Li, Tongtong Wang, Xiaotong Liu, Wenting Chen, Qingshan Ma, Muhammad Zahoor, Changfa Wang   +7 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Comprehensive genomic analysis of genetic diversity, body size, and origins of the Hetian Gray donkey

BMC Genomics
Background The Hetian Gray donkey, characterized by its large stature and gray coat color, is a relatively recently identified breed. This breed plays an important role in local agricultural practices and cultural heritage.
Yuan-Yuan Li, Yu Liu, Shu-Qin Liu, Yu-Gang He, Xiao-Ran Lin, Ying Li, Tao Yang, Mo Feng, He-Tong Zhang, Xin-Yu Wang, Ru-Yu Yao, Meng-Han Zhou, Chun-Jiang Zhao   +12 more
doaj   +1 more source