Developmental Dynamics, EarlyView.Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard +3 more
wiley +1 more source
Effect of Selenium-Enriched Donkey Milk on Lipid Metabolism Disorders Induced by a High-Fat Diet. [PDF]
FoodsZhong Q +10 more
europepmc +1 more source
Zebrafish inversin mutants develop scoliosis in the absence of laterality defects
Developmental Dynamics, EarlyView.Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick +3 more
wiley +1 more source
Movement Ecology and Disease Exposure in Free-Roaming Donkeys in California, USA. [PDF]
Animals (Basel)King SRB +3 more
europepmc +1 more source
Jaw‐specific stem cell dynamics are associated with distinct enamel architecture in mouse incisors
Developmental Dynamics, EarlyView.Abstract Background The continuously growing mouse incisor serves as a model for stem cell‐driven tooth renewal. Although mice possess maxillary and mandibular incisors, most studies have focused on the mandible. Potential differences in structure and renewal between these serially homologous organs remain insufficiently characterized.
Elias Shahin +4 more
wiley +1 more source
Protocol for ultrafast immunolabeling and 3D imaging of whole organs and large tissues. [PDF]
STAR ProtocDing Z, Liu H, Chen J, Kusumbe AP.
europepmc +1 more source
Anterior cingulate cortex neuron subtypes differentially regulate seizures
Epilepsia, EarlyView.Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan +12 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch +5 more
wiley +1 more source
Isolation of toxigenic <i>Corynebacterium diphtheriae</i> from cutaneous lesions in a donkey in Ontario, Canada, 2024: Implications for zoonotic disease transmission and One Health approach. [PDF]
Can Commun Dis RepOkechukwu C +9 more
europepmc +1 more source
Fatalities within seven days after equine standing sedation: A prospective, multicentre study
Equine Veterinary Journal, EarlyView.Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla +6 more
wiley +1 more source