Results 191 to 200 of about 276,302 (380)
Advanced Science, EarlyView.Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang +9 more
wiley +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
The Journal of Thoracic and Cardiovascular Surgery, 2017 Joanna, Chikwe, David H, Adams
openaire +2 more sources
Donkey production systems and breeding practices in selected districts of South Omo Zone, southern Ethiopia [PDF]
, 2023 Awoke Melak Wassie +4 more
openalex +1 more source
Advanced Science, EarlyView.This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong +6 more
wiley +1 more source
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
Advanced Science, EarlyView.ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Characterising donkey welfare challenges and opportunities associated with human activities and environmental factors in seven Kenyan counties. [PDF]
Anim WelfKithuka JM +3 more
europepmc +1 more source
Two men wearing traditional homespun clothes are standing next to a donkey.The original negative is at the The National Museum of Bosnia and Herzegovina. Donated to the The Austrian Museum of Folk Life and Folk Art by Dr.
core +1 more source
From Beast of Burden to Dairy Animal: Transforming Donkey Husbandry for Human Nutrition and Health
Khem Chand +5 more
openalex +1 more source