Results 41 to 50 of about 259,781 (292)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Effect of Sperm Cryopreservation in Farm Animals Using Nanotechnology

open access: yesAnimals, 2022
Sperm cryopreservation is one of the sublime biotechnologies for assisted reproduction. In recent decades, there has been an increasing trend in the use of preserved semen.
Muhammad Faheem Akhtar   +6 more
doaj   +1 more source

The Old Testament prophecy about the ass's foal of the Messiah and donkey-terminology [PDF]

open access: yes, 2012
The donkey is charged with a rich, important biblical symbolism. Usually the kings choose a strong and combatant animal for ceremonies – a thoroughbred horse, an imposing elephant or even a camel.
Almalech, Mony
core  

Serial fiction, the End? [PDF]

open access: yes, 2015
Andrew McGonigal presents some interesting data concerning truth in serial fictions.1 Such data has been taken by McGonigal, Cameron and Caplan to motivate some form of contextualism or relativism.
Walters, Lee
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Donkey and Tiger [PDF]

open access: yes, 2011
MP4 video‘Donkey and Tiger’ was told by Rgyal mtshan in A mdo Tibetan. Rta rgyugs, a subdivision of Rka phug Administrative Village, is a farming village located in Khams ra Town, Gcan tsa County Town, Rma lho Tibetan Autonomous Prefecture, Qinghai ...
Rdo rje don 'grub
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Comment on Ssuna et al. Animal Welfare Guidelines for International Development Organisations in the Global South. Animals 2024, 14, 2012

open access: yesAnimals
International Development Organisations (IDOs) undertake critical work to improve the lives of people across the world, particularly in the Global South [...]
Jo Hockenhull   +4 more
doaj   +1 more source

May the force be with you: an investigation into logging methods using donkeys

open access: yesAustral Journal of Veterinary Sciences, 2023
Working equids represent major sources of energy worldwide, and assume an increasingly important role in line with increasing requirements for sustainable energy.
João Rodrigues   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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