Thiazolylcyanocyclopropanes: Novel Donor–Acceptor Cyclopropanes for Accessing Thiazole-Containing Targets [PDF]
MoleculesDonor–acceptor (D–A) cyclopropanes are important precursors in the synthesis of complex molecules due to their bidentate character and high reactivity.
Emanuèl Bruno Savini +5 more
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Donor‐Acceptor Cyclopropanes: Activation Enabled by a Single, Vinylogous Acceptor [PDF]
Angewandte Chemie - International Edition, 2023 A novel class of highly activated donor‐acceptor cyclopropanes bearing only a single, vinylogous acceptor is presented. These strained moieties readily undergo cycloadditions with aldehydes, ketones, thioketones, nitriles, naphth‐2‐ols and various other ...
Daniel B Werz
exaly +3 more sources
Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines [PDF]
Molecules, 2022 We developed a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor–acceptor cyclopropanes bearing an ester group as one of the acceptor substituents.
Maksim A. Boichenko +9 more
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Transition-Metal-Free [3+2] Dehydration Cycloaddition of Donor-Acceptor Cyclopropanes With 2-Naphthols [PDF]
Frontiers in Chemistry, 2021 A Brønsted acid-catalyzed domino ring-opening cyclization transformation of donor-acceptor (D-A) cyclopropanes and 2-naphthols has been developed.
Hua Zhao +4 more
doaj +2 more sources
Accessing Azetidines through Magnesium-Mediated Nitrogen Group Transfer from Iminoiodinane to Donor-Acceptor Cyclopropanes. [PDF]
Angew Chem Int Ed EnglHerein, we report a Lewis acid-mediated ring expansion of donor-acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane.
Bansode AH +5 more
europepmc +2 more sources
Ferrocenyl-substituted tetrahydrothiophenes via formal [3 + 2]-cycloaddition reactions of ferrocenyl thioketones with donor–acceptor cyclopropanes [PDF]
Beilstein Journal of Organic Chemistry, 2020 Ferrocenyl thioketones reacted with donor–acceptor cyclopropanes in dichloromethane at room temperature in the presence of catalytic amounts of Sc(OTf)3 yielding tetrahydrothiophene derivatives, products of formal [3 + 2]-cycloaddition reactions, in ...
Grzegorz Mlostoń +4 more
doaj +2 more sources
(4+3) Annulation of Donor-Acceptor Cyclopropanes and Azadienes: Highly Stereoselective Synthesis of Azepanones. [PDF]
Angew Chem Int Ed Engl, 2022 Azepanes are important seven‐membered heterocycles, which are present in numerous natural and synthetic compounds. However, the development of convergent synthetic methods to access them remains challenging.
Nicolai S, Waser J.
europepmc +2 more sources
Enantioselective (8+3) Cycloadditions by Activation of Donor-Acceptor Cyclopropanes Employing Chiral Brønsted Base Catalysis. [PDF]
Angew Chem Int Ed Engl, 2022 A novel enantioselective (8+3) cycloaddition between donor–acceptor cyclopropanes and heptafulvenoids catalysed by a chiral bifunctional Brønsted base is described.
McLeod DA +5 more
europepmc +2 more sources
Nickel(II)-Catalyzed Formal [3+2] Cycloadditions between Indoles and Donor–Acceptor Cyclopropanes [PDF]
MoleculesThis article describes the development of a nickel-catalyzed regio- and diastereoselective formal [3+2] cycloaddition between N-substituted indoles and donor–acceptor cyclopropanes to synthesize cyclopenta[b]indoles. Optimized reaction conditions provide
Víctor Quezada +9 more
doaj +2 more sources
Synthesis of β-enamino malonates through caesium carbonate-promoted reaction of nitro-substituted donor-acceptor cyclopropanes. [PDF]
RSC AdvA caesium carbonate-promoted reaction of nitro-substituted donor–acceptor cyclopropanes (DACs) with primary aromatic amines in water provides a convenient access to β-enamino malonates under mild reaction conditions.
Jeny SR +3 more
europepmc +2 more sources