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Absence of IL-6 Receptor Blockade Effect on the Outcomes of Transplant Glomerulopathy in the Absence of Anti-HLA Donor-specific Antibodies. [PDF]

Transplant Direct
Mella A, Lavacca A, Dodoi DT, Presta R, Fop F, Campagna M, Manzione AM, Dolla C, Gallo E, Abbasciano I, Gai C, Camussi G, Barreca A, Caorsi C, Giovinazzo G, Biancone L.   +15 more
europepmc   +1 more source

Donor Specific Antibodies After Transplantation [PDF]

Pediatric Transplantation, 2011
Platt JL, Cascalho M. Donor specific antibodies after transplantation.
Pediatr Transplantation 2011: 15: 686–690. © 2011 John Wiley & Sons A/S.Abstract: The detection of donor‐specific antibodies after organ transplantation might provide an incisive way to monitor allo‐specific immunity and predict graft outcome.
Marilia Cascalho, Jeffrey L Platt
exaly   +4 more sources

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Donor-specific antibodies and liver transplantation

Human Immunology, 2016
In contrast to other types of organ transplantation, liver-transplant recipients used to be considered highly resistant to donor-specific antibodies (DSAs). Consequently, most transplant programs did not consider the presence of DSAs at transplantation or during the follow-up.
Arnaud, Del Bello, Nicolas, Congy-Jolivet, Marie, Danjoux, Fabrice, Muscari, Nassim, Kamar   +4 more
openaire   +2 more sources

Donor-specific antibodies in lung transplantation

Current Opinion in Organ Transplantation, 2020
Purpose of review The development of donor-specific antibodies (DSA) after lung transplantation has been recognized as an important risk factor for poor outcomes over the past 20 years. Recently, this has been a focus of intense research, and the purpose of this review is to summarize our current understanding of humoral ...
openaire   +2 more sources

Impact of donor-specific antibodies in reconstructive transplantation

Expert Review of Clinical Immunology, 2013
For many devastating injuries and tissue defects where conventional reconstruction is not possible, reconstructive transplantation such as hand and face transplantation has become a viable alternative. This novel approach allows for improved restoration of appearance, anatomy and function not feasible by other available treatment options.
Angelo A, Leto Barone, Zhaoli, Sun, Robert A, Montgomery, W P Andrew, Lee, Gerald, Brandacher   +4 more
openaire   +2 more sources

Increasing relevance of donor-specific antibodies in antibody-mediated rejection

Journal of Nephrology, 2012
One of the major concerns in organ transplantation is the early detection of humoral rejection, through improved diagnostic and prognostic biomarkers. Long-term survival of renal allografts is significantly lower in recipients developing donor-specific anti-HLA antibodies (DSAs) either pretransplant or posttransplant.
Zito A, Schena A, Grandaliano G, Schena F.P., GESUALDO, Loreto   +4 more
openaire   +3 more sources

Donor-specific antibody and sensitized patients in intestinal transplantation

Current Opinion in Organ Transplantation, 2021
Purpose of review It has been well established that antibody to donor HLA pretransplant and the development of anti-human leukocyte antigen (HLA) antibodies posttransplant contribute to inferior graft survival outcomes. This article serves to review the current status of the management of pretransplant sensitized intestinal ...
Cal S, Matsumoto, Sandra, Rosen-Bronson
openaire   +2 more sources

Safety of Crossing Donor-specific Antibodies in Lung Transplantation

Transplantation, 2022
Background. Donor-specific antibodies (DSAs) have been associated with antibody-mediated rejection, chronic lung allograft dysfunction (CLAD), and increased mortality in lung transplant recipients. Our center performs transplants in the presence of DSA, and we sought to evaluate the safety of this practice with respect to graft
Melissa, Wang, Patricia, Campbell, Dale C, Lien, Rhea, Varughese, Justin, Weinkauf, Jayan, Nagendran, Alim, Hirji, David, Li, Kieran, Halloran   +8 more
openaire   +2 more sources

Donor-specific antibodies and antibody-mediated rejection in vascularized composite allotransplantation

Current Opinion in Organ Transplantation, 2016
The presence of donor-specific antibodies (DSA) increases the risk of graft failure. Although DSA characteristics, human leukocyte antigen class specificity, mean fluorescence intensity and immunoglobulin G subclasses, and their impact on the graft are quite well studied in solid organ transplants, very little information is known about their impact on
Annemarie, Weissenbacher, Alexandre, Loupy, Anil, Chandraker, Stefan, Schneeberger   +3 more
openaire   +2 more sources

Significance of Donor-Specific Antibodies in Acute Rejection

Transplantation Proceedings, 2005
Significant advances in recent years in the diagnosis of antibody-mediated graft rejection have led to the re-evaluation of humoral alloreactivity in organ transplantation. By introducing the "C4d-test" into the work-up of transplant biopsies, donor-specific antibodies were claimed to be directly involved in about 30% of acute rejection episodes.
openaire   +2 more sources