Successful eradication of de novo HLA antibodies with daratumumab in immune-mediated cytopenias after allogeneic stem cell transplantation: a case report [PDF]
Annals of HematologyRefractory immune-mediated cytopenias (IMCs) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are a challenging complication with limited therapeutic options. Although preexisting human leukocyte antigen (HLA) antibodies, particularly
Xianfu Sheng +6 more
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Risk assessment of antibody-mediated damage based on the detection of HLA and non-HLA antibodies toward extracellular antigens before kidney transplantation [PDF]
Frontiers in ImmunologyIntroductionDonor-specific human leukocyte antigens antibodies (HLA-DSA) contribute toantibody-mediated rejection (ABMR) after kidney transplantation (KT).
Eulàlia Solà-Porta +20 more
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Frontiers in Immunology, 2021 BackgroundCorrelation between antibody-mediated rejection (ABMR) and circulating HLA donor-specific antibodies (HLA-DSA) is strong but imperfect in kidney transplant (KT) recipients, raising the possibility of undetected HLA-DSA or non-HLA antibodies ...
Marta Crespo +27 more
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Anti-HLA antibodies bound to monocytes altered antibody-mediated platelet phagocytosis and led to mild thrombocytopenia [PDF]
Frontiers in ImmunologyBackgroundIn fetal and neonatal alloimmune thrombocytopenia (FNAIT), maternal antibodies react with alloantigen expressed on fetal platelets, leading to their clearance via antibody-dependent phagocytosis.
Xiuzhang Xu +14 more
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Antigen and Cell-Based Assays for the Detection of Non-HLA Antibodies [PDF]
Frontiers in Immunology, 2022 To date, human leukocyte antigens (HLA) have been the major focus in the approach to acute and chronic antibody-mediated rejection (AMBR) in solid-organ transplantation.
Rosa G. M. Lammerts +5 more
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Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients [PDF]
Transplant InternationalAntibody-mediated rejection (ABMR) is the leading cause of long-term graft loss in pediatric kidney transplantation (KTx). While donor-specific HLA antibodies are established contributors, emerging evidence suggests a role for non-HLA antibodies in ABMR ...
Franziska Schmidt +8 more
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Transfusion-induced HLA antibodies are short-lived and rarely recur post-heart transplantation: a single-center retrospective study with implications for virtual crossmatching [PDF]
Frontiers in ImmunologyIntroductionThe development of human leukocyte antigen (HLA) antibodies poses a major challenge in transplantation by limiting donor compatibility and increasing the risk of graft failure.
Raja Rajalingam +6 more
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Prevalence of anti-HLA antibodies in COVID-19 convalescent plasma donors: an Indian experience [PDF]
Hematology, Transfusion and Cell TherapyBackground: COVID-19 convalescent plasma is one of the experimental therapies used widely in moderately sick COVID-19 patients. However, there are a few risks involved in plasma transfusion; notably, transfusion-related acute lung injury (TRALI) caused ...
Ram Mohan Jaiswal +6 more
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Frontiers in Immunology, 2022 Enveloped viruses, including the Human Immunodeficiency Virus-1 (HIV), incorporate host proteins such as human leucocyte antigens (HLA) into their envelope.
Melinda S. Suchard +23 more
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Frontiers in Immunology, 2023 IntroductionAntibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation. Anti-HLA donor-specific antibodies (DSA) of the IgG isotype are mainly responsible for ABMR.
Jasmin Mucha +16 more
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