Non-HLA Antibodies and Epitope Mismatches in Kidney Transplant Recipients With Histological Antibody-Mediated Rejection [PDF]
Frontiers in Immunology, 2021 BackgroundCorrelation between antibody-mediated rejection (ABMR) and circulating HLA donor-specific antibodies (HLA-DSA) is strong but imperfect in kidney transplant (KT) recipients, raising the possibility of undetected HLA-DSA or non-HLA antibodies ...
Marta Crespo +2 more
exaly +4 more sources
Antigen and Cell-Based Assays for the Detection of Non-HLA Antibodies [PDF]
Frontiers in Immunology, 2022 To date, human leukocyte antigens (HLA) have been the major focus in the approach to acute and chronic antibody-mediated rejection (AMBR) in solid-organ transplantation.
Rosa G. M. Lammerts +5 more
doaj +2 more sources
Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights [PDF]
Biomedicines, 2022 The polymorphic human leukocyte antigen (HLA) system has been considered the main target for alloimmunity, but the non-HLA antibodies and autoimmunity have gained importance in kidney transplantation (KT).
Bogdan Marian Sorohan +7 more
doaj +2 more sources
Impact of everolimus plus calcineurin inhibitor on formation of non-HLA antibodies and graft outcomes in kidney transplant recipients: 12-month results from the ATHENA substudy [PDF]
Frontiers in Transplantation, 2023 BackgroundNon-human leukocyte antigen (non-HLA) antibodies including antibodies targeting Angiotensin II type 1 (AT1R) and Endothelin-1 type A (ETAR) receptors represent a topic of interest in kidney transplantation (KTx).
Aurélie Philippe +14 more
doaj +2 more sources
Risk assessment of antibody-mediated damage based on the detection of HLA and non-HLA antibodies toward extracellular antigens before kidney transplantation [PDF]
Frontiers in ImmunologyIntroductionDonor-specific human leukocyte antigens antibodies (HLA-DSA) contribute toantibody-mediated rejection (ABMR) after kidney transplantation (KT).
Eulàlia Solà-Porta +20 more
doaj +2 more sources
Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients [PDF]
Transplant InternationalAntibody-mediated rejection (ABMR) is the leading cause of long-term graft loss in pediatric kidney transplantation (KTx). While donor-specific HLA antibodies are established contributors, emerging evidence suggests a role for non-HLA antibodies in ABMR ...
Franziska Schmidt +8 more
doaj +2 more sources
Non-HLA Antibodies in Kidney Transplantation: Mediators of Allograft Injury or Markers of Dysregulated Humoral Immunity? [PDF]
Medical SciencesAntibody-mediated rejection (AMR) remains a major cause of kidney allograft injury and loss. Although donor-specific antibodies against human leukocyte antigens (HLA-DSAs) are central to humoral alloimmunity, they do not explain all cases of ...
Ariadni Fouza, Maria Daoudaki
doaj +2 more sources
Prevalence of non-HLA antibodies and their association with FIB-4 index-based fibrosis risk in pediatric liver transplant recipients with long-term graft survival (>10 years) [PDF]
Frontiers in ImmunologyBackgroundWhile donor-specific antibodies against human leukocyte antigens (HLA-DSA) are recognized contributors to allograft injury, non-HLA antibodies are increasingly implicated in solid-organ transplant rejection. However, evidence in pediatric liver
Ricardo Cuesta-Martín de la Cámara +36 more
doaj +2 more sources
Understanding the role of non-HLA antibodies in kidney transplantation: a literature review [PDF]
Frontiers in ImmunologyNon-HLA antibodies have emerged as important contributors to antibody-mediated rejection and long-term graft dysfunction in kidney transplantation, including in patients without detectable donor-specific antibodies against human leukocyte antigens (HLA ...
Raffin Ryeed +7 more
doaj +2 more sources
Frontiers in Immunology, 2022 BackgroundMany kidney allografts fail due to the occurrence of antibody-mediated rejection (ABMR), related to donor-specific anti-HLA antibodies (HLA-DSA). However, the histology of ABMR can also be observed in patients without HLA-DSA.
Aleksandar Senev +13 more
doaj +1 more source