Results 21 to 30 of about 11,147,122 (280)

Non-HLA Antibodies in Hand Transplant Recipients Are Connected to Multiple Acute Rejection Episodes and Endothelial Activation. [PDF]

J Clin Med, 2022
The role of anti-HLA antibodies in transplant rejection is well-known but the injury associated with non-HLA antibodies is now widely discussed. The aim of our study was to investigate a role of non-HLA antibodies in hand allografts rejection.
Sikorska D, Kamińska D, Catar R, Banasik M, Heidecke H, Schulze-Forster K, Korybalska K, Rutkowski R, Łuczak J, Jabłecki J, Oko A, Daroszewski P, Kusztal M, Samborski W.   +13 more
europepmc   +2 more sources

A Comprehensive Overview of the Clinical Relevance and Treatment Options for Antibody-mediated Rejection Associated With Non-HLA Antibodies. [PDF]

Transplantation, 2021
Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor-specific ...
Kardol-Hoefnagel T, Otten HG.
europepmc   +2 more sources

Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment. [PDF]

Int J Mol Sci
Alloimmunization remains a major obstacle to successful kidney transplantation, mainly due to the formation of anti-HLA antibodies. In recent years, non-HLA antibodies have emerged as additional immunologic factors that can potentially contribute to ...
Mujić Franić A, Lilić M, Katalinić N, Glavaš-Obrovac L.   +3 more
europepmc   +2 more sources

Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection

Transplantation Direct, 2021
Background. Antibody-mediated rejection (AMR) causes more than 50% of late kidney graft losses. In addition to anti-human leukocyte antigen (HLA) donor-specific antibodies, antibodies against non-HLA antigens are also linked to AMR.
Sergi Clotet-Freixas, PhD, Max Kotlyar, PhD, Caitriona M. McEvoy, MD, PhD, Chiara Pastrello, PhD, Sonia Rodríguez-Ramírez, MD, Sofia Farkona, PhD, Heloise Cardinal, MD, PhD, Mélanie Dieudé, PhD, Marie-Josée Hébert, MD, PhD, Yanhong Li, BSc, Olusegun Famure, MPH, MEd,, Peixuen Chen, HBSc, BScN, S. Joseph Kim, MD, PhD, Emilie Chan, MD, Igor Jurisica, PhD, Rohan John, MD, Andrzej Chruscinski, MD, PhD, Ana Konvalinka, MD, PhD   +17 more
doaj   +1 more source

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Antibodies, 2022
Serum anti-HLA-I IgG are present in non-alloimmunized males, cancer patients, and transplant recipients. Anti-HLA-I antibodies are also present in intravenous immunoglobulin (IVIg), prepared from the plasma of thousands of healthy donors.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Fatiha El Hilali, Senthamil R. Selvan, Edward J. Filippone   +4 more
doaj   +1 more source

Prospective assessment of pre-existing and de novo anti-HLA IgE in kidney, liver, lung and heart transplantation

Frontiers in Immunology, 2023
IntroductionAntibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation. Anti-HLA donor-specific antibodies (DSA) of the IgG isotype are mainly responsible for ABMR.
Jasmin Mucha, Ara Cho, Ara Cho, Anna Marianne Weijler, Moritz Muckenhuber, Amun Georg Hofmann, Markus Wahrmann, Andreas Heinzel, Birgit Linhart, Pia Gattinger, Rudolf Valenta, Rudolf Valenta, Gabriela Berlakovich, Andreas Zuckermann, Peter Jaksch, Rainer Oberbauer, Thomas Wekerle   +16 more
doaj   +1 more source

Antibodies Reactive to Non-HLA Antigens in Transplant Glomerulopathy [PDF]

Journal of the American Society of Nephrology, 2011
Although T and B cell alloimmunity contribute to transplant injury, autoimmunity directed at kidney-expressed, non-HLA antigens may also participate. Because the specificity, prevalence, and importance of antibodies to non-HLA antigens in late allograft injury are poorly characterized, we used a protein microarray to compare antibody repertoires in pre-
Rajani, Dinavahi, Ajish, George, Anne, Tretin, Enver, Akalin, Scott, Ames, Jonathan S, Bromberg, Graciela, Deboccardo, Nicholas, Dipaola, Susan M, Lerner, Anita, Mehrotra, Barbara T, Murphy, Tibor, Nadasdy, Estela, Paz-Artal, Daniel R, Salomon, Bernd, Schröppel, Vinita, Sehgal, Ravi, Sachidanandam, Peter S, Heeger   +17 more
openaire   +2 more sources

Antibodies to the Mr 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired Beta-cell function [PDF]

, 1992
A prospective study of a normal childhood population identified 44 islet cell antibody positive individuals. These subjects were typed for HLA DR and DQ alleles and investigated for the presence of antibodies to the Mr 64,000 (64K) islet cell antigen ...
Glück, Michael, Bretzel, Reinhard G., Federlin, Konrad, Seißler, Jochen, Hering, Bernhard J., Böhm, Bernhard Otto, Yassin, Nuha, Scherbaum, Werner A., Richter, Wiltrud   +8 more
core   +1 more source

Posttransplant de novo DSA and NDSA affect GvHD, OS, and DFS after haplo-HSCT in patients without pre-existing HLA antibodies of hematological malignancies

Frontiers in Immunology, 2022
To examine the production time, type, and MFI of post-transplantation de novo HLA antibodies, and their effects on haplo-HSCT outcomes, we retrospectively included 116 patients who were negative for pre-existing HLA antibodies.
Lan Wang, Lan Wang, Kai Ji, Luyao Chen, Ying Li, Ying Li, Wenjuan Zhu, Wenjuan Zhu, Xiaoni Yuan, Xiaojing Bao, Xiaojin Wu, Xiaojin Wu, Jun He, Jun He   +13 more
doaj   +1 more source

Complement-Mediated Virus Infectivity Neutralisation by HLA Antibodies Is Associated with Sterilising Immunity to SIV Challenge in the Macaque Model for HIV/AIDS. [PDF]

, 2014
Sterilising immunity is a desired outcome for vaccination against human immunodeficiency virus (HIV) and has been observed in the macaque model using inactivated simian immunodeficiency virus (SIV).
Mark Robinson, Hassall, M, Stott James, Quartey-Papafio, R, Martin Cranage, Cranage, M, Page Mark, James Stott, Robinson Mark, Mark Hassall, Mark Page, Robinson, M, Quartey-Papafio Ruby, Page, M, Neil Almond, Hassall Mark, Almond, N, Almond Neil, Ruby Quartey-Papafio, Cranage Martin, Stott, J   +20 more
core   +1 more source