Non-HLA antibody trajectories may predict kidney transplant outcomes [PDF]
Frontiers in ImmunologyIntroductionDonor-specific HLA antibodies (DSAs) are well-established mediators of antibody-mediated rejection (AMR), but growing evidence suggests that non-HLA antibodies may also contribute to kidney allograft dysfunction. However, the clinical utility
Raja Rajalingam +8 more
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Beyond HLA: an exploratory pilot study of non-HLA antibodies, HLA sensitization, and GSTT1 genotype in platelet transfusion refractoriness [PDF]
Frontiers in ImmunologyObjectivesPlatelet transfusion refractoriness (PTR) is a common and clinically challenging condition with complex underlying mechanisms. Human leukocyte antigen (HLA) alloimmunization is the principal cause of immune PTR (iPTR), whereas non-HLA ...
Jun Qi +10 more
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Antigen and Cell-Based Assays for the Detection of Non-HLA Antibodies [PDF]
Frontiers in Immunology, 2022 To date, human leukocyte antigens (HLA) have been the major focus in the approach to acute and chronic antibody-mediated rejection (AMBR) in solid-organ transplantation.
Rosa G. M. Lammerts +5 more
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Challenges and opportunities in bringing non-HLA antibody testing for post-transplant monitoring [PDF]
Frontiers in TransplantationEvidence for the contribution of non-HLA antibodies on long-term allograft outcome was suggested in early studies by Paul Terasaki and colleagues who showed worse 10-year allograft outcome in HLA identical kidney transplant recipients with a positive ...
Mary Carmelle Philogene +2 more
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Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights [PDF]
Biomedicines, 2022 The polymorphic human leukocyte antigen (HLA) system has been considered the main target for alloimmunity, but the non-HLA antibodies and autoimmunity have gained importance in kidney transplantation (KT).
Bogdan Marian Sorohan +7 more
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Risk assessment of antibody-mediated damage based on the detection of HLA and non-HLA antibodies toward extracellular antigens before kidney transplantation [PDF]
Frontiers in ImmunologyIntroductionDonor-specific human leukocyte antigens antibodies (HLA-DSA) contribute toantibody-mediated rejection (ABMR) after kidney transplantation (KT).
Eulàlia Solà-Porta +20 more
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Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients [PDF]
Transplant InternationalAntibody-mediated rejection (ABMR) is the leading cause of long-term graft loss in pediatric kidney transplantation (KTx). While donor-specific HLA antibodies are established contributors, emerging evidence suggests a role for non-HLA antibodies in ABMR ...
Franziska Schmidt +8 more
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Prevalence of non-HLA antibodies and their association with FIB-4 index-based fibrosis risk in pediatric liver transplant recipients with long-term graft survival (>10 years) [PDF]
Frontiers in ImmunologyBackgroundWhile donor-specific antibodies against human leukocyte antigens (HLA-DSA) are recognized contributors to allograft injury, non-HLA antibodies are increasingly implicated in solid-organ transplant rejection. However, evidence in pediatric liver
Ricardo Cuesta-Martín de la Cámara +36 more
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Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms [PDF]
Cell GenomicsSummary: Type 1 diabetes (T1D) and other autoimmune diseases (AIDs) often co-occur in families. Leveraging data from 58,284 family trios in Finnish nationwide registers (FinRegistry), we identified that, of 50 parental AIDs examined, 15 were associated ...
Feiyi Wang +12 more
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Expanding the Genetic Framework: Insights into Non-HLA-B27 Contributions to Axial Spondylarthritis [PDF]
MedicinaBackground and Objectives: Spondylarthritis is a complex group of inflammatory diseases closely associated with the HLA-B27 antigen. However, the role of non-HLA-B27 alleles in the disease’s pathogenesis has gained significant scholarly attention in ...
Ruxandra-Elena Nagit +5 more
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