Results 41 to 50 of about 10,792,655 (300)

Antibodies Reactive to Non-HLA Antigens in Transplant Glomerulopathy [PDF]

Journal of the American Society of Nephrology, 2011
Although T and B cell alloimmunity contribute to transplant injury, autoimmunity directed at kidney-expressed, non-HLA antigens may also participate. Because the specificity, prevalence, and importance of antibodies to non-HLA antigens in late allograft injury are poorly characterized, we used a protein microarray to compare antibody repertoires in pre-
Rajani, Dinavahi, Ajish, George, Anne, Tretin, Enver, Akalin, Scott, Ames, Jonathan S, Bromberg, Graciela, Deboccardo, Nicholas, Dipaola, Susan M, Lerner, Anita, Mehrotra, Barbara T, Murphy, Tibor, Nadasdy, Estela, Paz-Artal, Daniel R, Salomon, Bernd, Schröppel, Vinita, Sehgal, Ravi, Sachidanandam, Peter S, Heeger   +17 more
openaire   +2 more sources

Non-HLA Abs in Solid Organ Transplantation [PDF]

Transplantology, 2020
The role of anti-HLA antibodies in solid organ rejection is well established and these antibodies are routinely monitored both in patients in the waiting list and in the post-transplant setting. More recently, the presence of other antibodies directed towards non-HLA antigens, or the so-called minor histocompatibility antigens, has drawn the attention ...
María Gutiérrez-Larrañaga, Marcos López-Hoyos, André Renaldo, David San Segundo   +3 more
openaire   +1 more source

HLA-H: Transcriptional Activity and HLA-E Mobilization

Frontiers in Immunology, 2020
Little attention is paid to pseudogenes from the highly polymorphic HLA genetic region. The pseudogene HLA-H is defined as a non-functional gene because it is deleted at different frequencies in humans and because it encodes a potentially non-functional ...
François Jordier, François Jordier, Delphine Gras, Maria De Grandis, Maria De Grandis, Xavier-Benoît D'Journo, Pascal-Alexandre Thomas, Pascal Chanez, Pascal Chanez, Christophe Picard, Christophe Picard, Jacques Chiaroni, Jacques Chiaroni, Julien Paganini, Julie Di Cristofaro, Julie Di Cristofaro   +15 more
doaj   +1 more source

Human Leukocyte Antigen Class II associations in late‐onset Myasthenia Gravis

Annals of Clinical and Translational Neurology, 2021
Objective Genetic factors predisposing to late‐onset myasthenia gravis (LOMG) have not been clearly defined yet. However, genome‐wide association studies identified Human Leukocyte Antigen (HLA) Class II alleles as a hotspot in this disease subtype.
Gregorio Spagni, Laura Todi, Gabriele Monte, Mariagrazia Valentini, Gabriele Di Sante, Valentina Damato, Mariapaola Marino, Amelia Evoli, Francesca Lantieri, Carlo Provenzano   +9 more
doaj   +1 more source

Integrated investigation of the prognostic role of HLA LOH in advanced lung cancer patients with immunotherapy

Frontiers in Genetics, 2022
Although multiple studies have shown that loss of heterozygosity (LOH) at the human leukocyte antigen (HLA) locus is one of the mechanisms of immune escape, the effect of HLA LOH on the immunotherapy response of patients is still unclear.
Xiaotao Zhang, Hongzhen Tang, Haitao Luo, Huiping Lu, Chaohu Pan, Haiming Yu, Linlin Zhang, Yaping Guan, Yaping Guan, Yaping Guan, Lan Yu, Huili Chu, Jun Chen, Jun Wang, Jun Wang, Jun Wang   +15 more
doaj   +1 more source

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Gekeler, V., Müller, C. A., Engler-Blum, G., Steiert, I., Weiss, Elisabeth H., Schmidt, H.   +5 more
core   +1 more source

DeepHLAPred: a deep learning-based method for non-classical HLA binder prediction

BMC Genomics, 2023
Human leukocyte antigen (HLA) is closely involved in regulating the human immune system. Despite great advance in detecting classical HLA Class I binders, there are few methods or toolkits for recognizing non-classical HLA Class I binders.
Guohua Huang, Xingyu Tang, Peijie Zheng
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source