Results 1 to 10 of about 31,480,937 (161)

Peptide occupancy governs HLA-E checkpoint interactions enabling VISTA recognition of destabilized HLA-E conformers [PDF]

Communications Biology
Human leukocyte antigen E (HLA-E) plays a central role in immune regulation across homeostasis, infection, cancer, and transplantation. Canonically, HLA-E presents leader sequence-derived VL9 peptides to engage CD94/NKG2 receptors, while alternative ...
Chelsae R. Watters, Soroush Ghaffari, Carly Wilder, Michael Donkor, Gizem Oter, Katherine Upchurch-Ange, Susanne Gimlin, Niksa Kastrapeli, Jon Weidanz   +8 more
doaj   +2 more sources

HLA-E–restricted T cells primed by a modified HLA-B*57:01–restricted HIV-1 peptide suppress HIV-1 replication [PDF]

JCI Insight
HLA-E–restricted HIV-specific T cells offer exciting possibilities for immunotherapy. However, HLA-E binding peptides are rare. A recent study showed that in HLA-B*57:01–positive people with HIV, the peptide that dominates the T cell response ...
Hong Sun, Hongbing Yang, Max N. Quastel, Simon Brackenridge, Wanlin He, Anna E. Kliszczak, Margarida Rei, Persephone Borrow, Geraldine M. Gillespie, Andrew J. McMichael   +9 more
doaj   +2 more sources

Conformation of HLA-E/peptide complex guides interaction with two novel HLA-E receptors: Stabilin 1 and 2. [PDF]

PLoS ONE
Human leukocyte antigen E (HLA-E) communicates cellular health to natural killer (NK) cells through presentation of peptides derived from the leader sequence of classical major histocompatibility complex class I (MHC-I), inhibiting NK cell activation and
Tom A W Schoufour, Linda Voogd, Kees L M C Franken, Tom H M Ottenhoff, Ruud H M Wijdeven, Simone A Joosten   +5 more
doaj   +2 more sources

HLA-E[pHLA-G] complex–specific monoclonal antibody enhancing NK activity in multiple myeloma [PDF]

Blood Advances
: HLA-E presenting the HLA-G leader peptide VMAPRTLFL (HLA-E[pHLA-G]) on tumor cells plays a crucial role in suppressing natural killer (NK) and cytotoxic CD8+ T cells through NKG2A interaction. While blocking HLA-E:NKG2A is a promising immune checkpoint
Muhammad Abu Ahmad, Olga Radinsky, Bar Kaufman, Kamran Waidha, Eman Gharra, Sharon Dim, Dinesh Babu Manikandan, Noa Ofir, Dirk Jäger, Marten Meyer, Moshe Elkabets, Kerry S. Campbell, Miri Zektser, Roi Gazit, Ory Rouvio, Frank Momburg, Angel Porgador   +16 more
doaj   +2 more sources

CD8+ T cells cross-restricted by HLA-B*57 and HLA-E*01 recognize HIV Gag with different functional profiles [PDF]

JCI Insight
Few HIV-specific epitopes restricted by non-classical HLA-E have been described, and even less is known about the functional profile of responding CD8+ T cells (CD8s).
Kevin J. Maroney, Michael A. Rose, Allisa K. Oman, Abha Chopra, Hua-Shiuan Hsieh, Zerufael Derza, Rachel Waterworth, Mark A. Brockman, Spyros A. Kalams, Anju Bansal, Paul A. Goepfert   +10 more
doaj   +2 more sources

HLA-E-restricted SARS-CoV-2 epitopes drive CD8+ T cell memory in convalescent and vaccinated individuals: implications for the design of next-generation vaccines and immunotherapeutics [PDF]

Journal of Translational Medicine
Background Human leukocyte antigen-E (HLA-E) is a non-polymorphic, non-classical HLA class Ib molecule that presents signal peptides from classical HLA class Ia molecules to natural killer (NK) cell receptors.
Mahsa Rafieiyan, Giusto Davide Badami, Nicola Scichilone, Salvatore Corrao, Vincenzo Restivo, Enzo Massimo Farinella, Martina Bottone, Gabriella Pietra, Miriana Fallo, Andrea Maria Aglio, Marco Pio La Manna, Francesco Dieli, Mojtaba Shekarkar Azgomi, Nadia Caccamo   +13 more
doaj   +2 more sources

The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E [PDF]

Frontiers in Immunology
The commonly used antibodies 3D12 and 4D12 recognise the human leukocyte antigen E (HLA-E) protein. These antibodies bind distinct epitopes on HLA-E and differ in their ability to bind alleles of the major histocompatibility complex E (MHC-E) proteins of
Simon Brackenridge, Nessy John, Klaus Früh, Persephone Borrow, Andrew J. McMichael   +4 more
doaj   +2 more sources

The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients [PDF]

Iranian Journal of Immunology, 2022
Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important ...
Masumeh Darai, Saeede Soleimanian, Ramin Yaghobi, Kourosh Kazemi, Saman Nikeghbalian, Negar Azarpira   +5 more
doaj   +1 more source

Participation of Single-Nucleotide Variants in IFNAR1 and IFNAR2 in the Immune Response against SARS-CoV-2 Infection: A Systematic Review

Pathogens, 2023
Host genetic factors significantly influence susceptibility to SARS-CoV-2 infection and COVID-19 severity. Among these genetic factors are single-nucleotide variants (SNVs). IFNAR2 and IFNAR1 genes have been associated with severe COVID-19 in populations
María Fernanda López-Bielma, Ramcés Falfán-Valencia, Edgar Abarca-Rojano, Gloria Pérez-Rubio   +3 more
doaj   +1 more source

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Antibodies, 2022
Serum anti-HLA-I IgG are present in non-alloimmunized males, cancer patients, and transplant recipients. Anti-HLA-I antibodies are also present in intravenous immunoglobulin (IVIg), prepared from the plasma of thousands of healthy donors.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Fatiha El Hilali, Senthamil R. Selvan, Edward J. Filippone   +4 more
doaj   +1 more source