Results 31 to 40 of about 31,480,937 (161)

HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome

Stem Cells International, 2015
The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. Structural analysis of HLA-E/NKG2A complexes visualized fine-tuning of protective immune responses through AA ...
Thomas Kraemer, Alexander A. Celik, Trevor Huyton, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding   +5 more
doaj   +1 more source

Identificação dos alelos HLA de classe I e classe II em pacientes co-infectados com hanseníase e AIDS

Hansenologia Internationalis, 2006
O complexo HLA tem sido amplamente estudado, na tentativa de elucidar os mecanismos que levam ao direcionamento da forma clínica na hanseníase. Foram observadas associações positivas dos alelos HLA-DR2 e HLA-DR3, com a forma tuberculóide (HT) e do alelo
Sônia Maria Usó Ruiz Silva, Claudia Peres Monteiro Carvalho, Elaine Valim Camarinha Marcos, Fabiana Covolo de Souza, Somei Ura, Ricardo Augusto Monteiro de Barros Almeida   +5 more
doaj   +1 more source

HLA-E Binding Peptide as a Potential Therapeutic Candidate for High-Risk Multiple Myeloma

Frontiers in Oncology, 2021
Human leukocyte antigen-E (HLA-E) has been putatively associated with the pathogenesis of multiple myeloma (MM). Our study first showed that HLA-E was differentially expressed on MM and normal plasma cells (39.27 ± 27.01 and 11.28 ± 0.79, respectively ...
Ying Yang, Zhuogang Liu, Hongtao Wang, Guojun Zhang   +3 more
doaj   +1 more source

High-throughput high-resolution class I HLA genotyping in East Africa. [PDF]

, 2010
HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria,
Leonard Maboko, Eller, Michael, Jerome Kim, Rebecca N Koehler, Francine E McCutchan, Michael Eller, Christian T Bautista, Hoelscher Michael, Eller, Leigh Anne, Jeffrey R Currier, Currier Jeffrey R., Nelson L Michael, Michael, Nelson L., Kijak, Gustavo H, Maboko Leonard, Michael, Nelson L, McCutchan, Francine E., Michael Nelson L., Maboko, Leonard, Walsh, Anne M, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Currier, Jeffrey R, Eller Michael, McCutchan, Francine E, Eric E Sanders-Buell, Sanders-Buell, Eric E., Robb, Merlin L, Robb Merlin L., Kijak Gustavo H., Leigh Anne Eller, Kim Jerome, Robb, Merlin L., Bautista Christian T., Anne M Walsh, Hoelscher, Michael, Kijak, Gustavo H., Bautista, Christian T, Michael Hoelscher, McCutchan Francine E., Kim, Jerome, Eller Leigh Anne, Koehler, Rebecca N, Merlin L Robb, Bautista, Christian T., Koehler, Rebecca N., Koehler Rebecca N., Sanders-Buell, Eric E, Sanders-Buell Eric E., Walsh, Anne M., Currier, Jeffrey R., Gustavo H Kijak, Walsh Anne M.   +53 more
core   +2 more sources

HLA-E⁎01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence

Journal of Immunology Research, 2016
Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem
Julie Di Cristofaro, Mathieu Pelardy, Anderson Loundou, Agnès Basire, Carine Gomez, Jacques Chiaroni, Pascal Thomas, Martine Reynaud-Gaubert, Christophe Picard   +8 more
doaj   +1 more source

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Gekeler, V., Müller, C. A., Engler-Blum, G., Steiert, I., Weiss, Elisabeth H., Schmidt, H.   +5 more
core   +1 more source

Antígenos HLA na febre reumática

Medicina, 2000
Antígenos HLA de classe I (HLA-A e HLA-B) e II (HLA-DR) foram tipificados em um grupo de 91 pacientes com as principais formas de apresentação da febre reumática, ou seja, coréia, cardite ou artrite.
Eduardo A. Donadi, Paula P.C. Lamparelli, Lídia Z. Figueiredo, Cássia M. Paula-Santos, Julio C. Voltarelli   +4 more
doaj   +1 more source

Identification of a novel HLA-C*08 allele, HLA-C*08:01:20

, 2017
HLA-C*08:01:20 differs from C*08:01:01 by a single nucleotide substitution at position 93 of exon 2.SCI(E)EDITORIAL MATERIAL3178 ...
D. Li, Yu, Y., B. Xi, M.-R. Huo, Xi, B., Li, D., Huo, M.R., Y. Yu   +7 more
core   +1 more source

Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer

International Journal of Breast Cancer, 2013
Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-
Gisela Bevilacqua Rolfsen Ferreira da Silva, Tarsia Giabardo Alves Silva, Roberta Aparecida Duarte, Nicolino Lia Neto, Hélio Humberto Angotti Carrara, Eduardo Antônio Donadi, Maria Alice Guimarães Gonçalves, Edson Garcia Soares, Christiane Pienna Soares   +8 more
doaj   +1 more source

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections

Frontiers in Immunology, 2022
The contribution of the HLA-E/NKG2X axis in NK-mediated control of HIV infection remains unclear. We have studied the relationship between HLA-E expression and phenotypical as well as functional characteristics of NK cells, in the context of chronic HIV ...
Luis Romero-Martín, Luis Romero-Martín, Clara Duran-Castells, Clara Duran-Castells, Mireia Olivella, Míriam Rosás-Umbert, Marta Ruiz-Riol, Marta Ruiz-Riol, Jorge Sanchez, Dennis Hartigan-O´Connor, Dennis Hartigan-O´Connor, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Àlex Olvera, Àlex Olvera, Àlex Olvera, Christian Brander, Christian Brander, Christian Brander, Christian Brander   +20 more
doaj   +1 more source