Results 31 to 40 of about 183,897 (254)
Dimorphism of HLA-E and Its Disease Association [PDF]
International Journal of Molecular Sciences, 2019 HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes.
Leonid Kanevskiy +5 more
openaire +2 more sources
Stem Cells International, 2015 The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. Structural analysis of HLA-E/NKG2A complexes visualized fine-tuning of protective immune responses through AA ...
Thomas Kraemer +5 more
doaj +1 more source
Hansenologia Internationalis, 2006 O complexo HLA tem sido amplamente estudado, na tentativa de elucidar os mecanismos que levam ao direcionamento da forma clínica na hanseníase. Foram observadas associações positivas dos alelos HLA-DR2 e HLA-DR3, com a forma tuberculóide (HT) e do alelo
Sônia Maria Usó Ruiz Silva +5 more
doaj +1 more source
Human Immunology, 2021 Hepatitis C virus usually produces chronic infection and liver damage. Considering that: i) the human leukocyte antigen-E (HLA-E) molecule may modulate the immune response, and ii) little is known about the role of HLA-E gene variability on chronic hepatitis C, we studied the impact of HLA-E polymorphisms on the magnitude of HLA-E liver expression and ...
Araujo, Roberta Chaves +11 more
openaire +3 more sources
Journal of Immunology Research, 2016 Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem
Julie Di Cristofaro +8 more
doaj +1 more source
Antígenos HLA na febre reumática
Medicina, 2000 Antígenos HLA de classe I (HLA-A e HLA-B) e II (HLA-DR) foram tipificados em um grupo de 91 pacientes com as principais formas de apresentação da febre reumática, ou seja, coréia, cardite ou artrite.
Eduardo A. Donadi +4 more
doaj +1 more source
Antibodies to HLA-E in Nonalloimmunized Males: Pattern of HLA-Ia Reactivity of Anti–HLA-E–Positive Sera [PDF]
The Journal of Immunology, 2010 Abstract Natural anti-HLA Abs found in sera of healthy nonalloimmunized males recognize HLA-Ia alleles parallel to those recognized by anti–HLA-E mAbs (MEM-E/02/06/07). Therefore, some of the HLA-Ia Abs seen in healthy males could be due to anti–HLA-E Abs cross-reacting with HLA-Ia.
Mepur H, Ravindranath +4 more
openaire +2 more sources
Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
Frontiers in Immunology, 2022 The contribution of the HLA-E/NKG2X axis in NK-mediated control of HIV infection remains unclear. We have studied the relationship between HLA-E expression and phenotypical as well as functional characteristics of NK cells, in the context of chronic HIV ...
Luis Romero-Martín +20 more
doaj +1 more source
Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
International Journal of Breast Cancer, 2013 Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-
Gisela Bevilacqua Rolfsen Ferreira da Silva +8 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala +8 more
wiley +1 more source