Results 21 to 30 of about 183,897 (254)

Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Frontiers in Immunology, 2023
Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the
Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, Ping Li   +12 more
doaj   +1 more source

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5

OncoImmunology, 2019
Although the proteasome inhibitor bortezomib has significantly improved the survival of patients with multiple myeloma (MM), the disease remains fatal as most patients eventually develop progressive disease.
Mattias Carlsten, Ali Namazi, Robert Reger, Emily Levy, Maria Berg, Cynthia St. Hilaire, Richard W. Childs   +6 more
doaj   +1 more source

High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis

Journal of Translational Medicine, 2011
Background Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that can be stabilized by ligands donated by other classical (HLA-A, -B, -C) and non-classical (HLA-G) family members.
Monaco Elisa Lo, Sperduti Isabella, Ercolani Cristiana, Diodoro Maria Grazia, Rollo Francesca, Tremante Elisa, Mottolese Marcella, Benevolo Maria, Cosimelli Maurizio, Giacomini Patrizio   +9 more
doaj   +1 more source

Persistent CD8 T Cell Marks Caused by the HCMV Infection in Seropositive Adults: Prevalence of HLA-E-Reactive CD8 T Cells

Cells, 2023
This study investigated the frequency and peptide specificity of long-lasting HCMV-specific CD8 T cells in a cohort of 120 cytomegalovirus seropositive (HCMV+) healthy carriers with the aim of deciphering the relative contribution of unconventional HLA-E-
Amélie Rousselière, Béatrice Charreau
doaj   +1 more source

Freqüência dos antígenos HLA-DR e DQ em pacientes brasileiros com diabetes mellitus tipo I

Medicina, 2000
A associação entre diabetes mellitus do tipo I com os genes HLA de classe II está bem estabelecida. Os genes podem ser diferentes de acordo com a etnia do grupo estudado.
Renata Nahas, Neifi H.S. Deghaide, Eduardo A. Donadi, Milton C. Foss   +3 more
doaj   +1 more source

Decreased Soluble Human Leukocyte Antigen E Levels in Patients After Allogeneic Hematopoietic Stem Cell Transplantation Are Associated With Severe Acute and Extended Chronic Graft-versus-Host Disease and Inferior Overall Survival

Frontiers in Immunology, 2020
HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more
Lambros Kordelas, Esther Schwich, Monika Lindemann, Falko M. Heinemann, Ulrike Buttkereit, Peter A. Horn, Dietrich W. Beelen, Vera Rebmann   +7 more
doaj   +1 more source

Association of HLA-A and Non-Classical HLA Class I Alleles.

PLoS ONE, 2016
The HLA-A locus is surrounded by HLA class Ib genes: HLA-E, HLA-H, HLA-G and HLA-F. HLA class Ib molecules are involved in immuno-modulation with a central role for HLA-G and HLA-E, an emerging role for HLA-F and a yet unknown function for HLA-H.
Federico Carlini, Virginia Ferreira, Stéphane Buhler, Audrey Tous, Jean-François Eliaou, Céline René, Jacques Chiaroni, Christophe Picard, Julie Di Cristofaro   +8 more
doaj   +1 more source

HLA-E expression in diffuse glioma: relationship with clinicopathological features and patient survival

BMC Neurology, 2020
Background Human leukocyte antigen-E (HLA-E) has been extensively investigated in various human cancers including glioma. However, the clinical significance of HLA-E expression in glioma patients has not been elucidated.
Zhifeng Wu, Jingshan Liang, Zheng Wang, Aimin Li, Xing Fan, Tao Jiang   +5 more
doaj   +1 more source

HLA-E Binding Peptide as a Potential Therapeutic Candidate for High-Risk Multiple Myeloma

Frontiers in Oncology, 2021
Human leukocyte antigen-E (HLA-E) has been putatively associated with the pathogenesis of multiple myeloma (MM). Our study first showed that HLA-E was differentially expressed on MM and normal plasma cells (39.27 ± 27.01 and 11.28 ± 0.79, respectively ...
Ying Yang, Zhuogang Liu, Hongtao Wang, Guojun Zhang   +3 more
doaj   +1 more source

Epstein-Barr virus peptide presented by HLA-E is predominantly recognized by CD8(bright) cells in multiple sclerosis patients.

PLoS ONE, 2012
Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, but impaired immune suppression may be part of the disease pathogenesis. CD8(+) T cells that are restricted by HLA-E exert an important immunoregulatory mechanism.
Pernille B Jørgensen, Astrid H Livbjerg, Hans J Hansen, Thor Petersen, Per Höllsberg   +4 more
doaj   +1 more source