Results 11 to 20 of about 31,480,937 (161)

Histological Characterization of Class I HLA Molecules in Whole Umbilical Cord Tissue Towards an Inexhaustible Graft Alternative for Reconstructive Surgery

Bioengineering, 2023
Background: Limited graft availability is a constant clinical concern. Hence, the umbilical cord (UC) is an attractive alternative to autologous grafts.
Yue Ying Yao, Dennis K. Lee, Stephanie Jarvi, Marjan Farshadi, Minzhi Sheng, Sara Mar, Ori Nevo, Hon S. Leong   +7 more
doaj   +1 more source

HLA-E-restricted Hantaan virus-specific CD8+ T cell responses enhance the control of infection in hemorrhagic fever with renal syndrome

Biosafety and Health, 2023
Infection with the Hantaan virus (HTNV) may result in severe hemorrhagic fever with renal syndrome (HFRS). The functions of HLA-E-restricted CD8+ T lymphocytes in virus control and vaccine development have recently received increased attention.
Kang Tang, Yusi Zhang, Xinyu Li, Chunmei Zhang, Xiaozhou Jia, Haifeng Hu, Lihua Chen, Ran Zhuang, Yun Zhang, Boquan Jin, Ying Ma   +10 more
doaj   +1 more source

ANTíGENOS HLA ESTÃO ASSOCIADOS A RISCO DE DIABETES MELLITUS PÓS-TRANSPLANTE?

Brazilian Journal of Transplantation, 2021
Introdução: Diabetes mellitus pós-transplante (DMPT) tem impacto na morbidade e na mortalidade em receptores de transplante renal, uma vez que aumenta o risco de complicações cardiovasculares e de perda do enxerto renal.
Débora Dias de Lucena, Renato de Marco, João Roberto de Sá, José Osmar Medina-Pestana, Maria Gerbase-DeLima, Érika Bevilaqua Rangel   +5 more
doaj   +1 more source

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by D94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis [PDF]

, 1998
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I ...
John E. Coligan, Matthias Ulbrecht, Ulbrecht, Matthias, Coligan, John E., Andrew G. Brooks, Brooks, AG, Borrego, F, Coligan, JE, Elisabeth H. Weiss, Brooks, Andrew G., Francisco Borrego, Borrego, Francisco, Weiss, Elisabeth H., Ulbrecht, M, Weiss, EH   +14 more
core   +1 more source

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source

The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein [PDF]

, 1992
An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated.
Honka, Thomas, Johnson, Judith P., Ulbrecht, Matthias, Person, Susanne, Weiss, Elisabeth H.   +4 more
core   +1 more source

Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Frontiers in Immunology, 2023
Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the
Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, Ping Li   +12 more
doaj   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Tabaczewski, P., Pohla, Heike, Heike Pohla, Kuon, W., Wolfgang Kuon, Piotr Tabaczewski, Doerner, C., Weiss, Elisabeth H., Christa Doerner, Elisabeth H. Weiss   +9 more
core   +1 more source

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5

OncoImmunology, 2019
Although the proteasome inhibitor bortezomib has significantly improved the survival of patients with multiple myeloma (MM), the disease remains fatal as most patients eventually develop progressive disease.
Mattias Carlsten, Ali Namazi, Robert Reger, Emily Levy, Maria Berg, Cynthia St. Hilaire, Richard W. Childs   +6 more
doaj   +1 more source

High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis

Journal of Translational Medicine, 2011
Background Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that can be stabilized by ligands donated by other classical (HLA-A, -B, -C) and non-classical (HLA-G) family members.
Monaco Elisa Lo, Sperduti Isabella, Ercolani Cristiana, Diodoro Maria Grazia, Rollo Francesca, Tremante Elisa, Mottolese Marcella, Benevolo Maria, Cosimelli Maurizio, Giacomini Patrizio   +9 more
doaj   +1 more source