Results 11 to 20 of about 188,808 (295)

The complex HLA-E-nonapeptide in Behçet disease [PDF]

Frontiers in Immunology, 2023
IntroductionThe knowledge of the aetiology of Behçet disease (BD), an immune-mediated vasculitis, is limited. HLA-B, mainly HLA-B51, and HLA-A molecules are associated with disease, but the ultimate cause of this association remains obscure. There is evidence that NK cells participate in the etiopathology of BD.
Ángel Luís Castaño-Núñez, Marco-Antonio Montes-Cano, José-Raúl García-Lozano, Norberto Ortego-Centeno, Francisco José García-Hernández, Gerard Espinosa, Genaro Graña-Gil, Juan Sánchez-Bursón, María Rosa Juliá, Roser Solans, Ricardo Blanco, Ana-Celia Barnosi-Marín, Ricardo Gómez de la Torre, Patricia Fanlo, Mónica Rodríguez-Carballeira, Luis Rodríguez-Rodríguez, Teresa Camps, Santos Castañeda, Juan-Jose Alegre-Sancho, Javier Martín, María Francisca González-Escribano   +20 more
openaire   +8 more sources

HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease [PDF]

Human Immunology, 2023
HLA-E interaction with inhibitory receptor, NKG2A attenuates NK-mediated cytotoxicity. NKG2A overexpression by SARS-CoV-2 exhausts NK cells function, whereas virus-induced down-regulation of MHC-Ia reduces its derived-leader sequence peptide levels required for proper binding of HLA-E to NKG2A.
Ehteramolsadat Hosseini, Arefeh Minagar, Mehran Ghasemzadeh, Ali Arabkhazaeli, Alireza Ghasemzadeh   +4 more
openaire   +3 more sources

Intracellular trafficking of HLA-E and its regulation [PDF]

Journal of Experimental Medicine, 2023
Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model. The development of vaccines and immunotherapies utilizing human MHC-E (HLA-E)–restricted CD8+ T cell response requires an understanding of the pathway(s) of HLA-E ...
Wanlin He, Ester Gea-Mallorquí, Huw Colin-York, Marco Fritzsche, Geraldine M. Gillespie, Simon Brackenridge, Persephone Borrow, Andrew J. McMichael   +7 more
openaire   +3 more sources

Conformation of HLA-E/peptide complex guides interaction with two novel HLA-E receptors: Stabilin 1 and 2. [PDF]

PLoS ONE
Human leukocyte antigen E (HLA-E) communicates cellular health to natural killer (NK) cells through presentation of peptides derived from the leader sequence of classical major histocompatibility complex class I (MHC-I), inhibiting NK cell activation and
Tom A W Schoufour, Linda Voogd, Kees L M C Franken, Tom H M Ottenhoff, Ruud H M Wijdeven, Simone A Joosten   +5 more
doaj   +2 more sources

HLA-E[pHLA-G] complex–specific monoclonal antibody enhancing NK activity in multiple myeloma [PDF]

Blood Advances
: HLA-E presenting the HLA-G leader peptide VMAPRTLFL (HLA-E[pHLA-G]) on tumor cells plays a crucial role in suppressing natural killer (NK) and cytotoxic CD8+ T cells through NKG2A interaction. While blocking HLA-E:NKG2A is a promising immune checkpoint
Muhammad Abu Ahmad, Olga Radinsky, Bar Kaufman, Kamran Waidha, Eman Gharra, Sharon Dim, Dinesh Babu Manikandan, Noa Ofir, Dirk Jäger, Marten Meyer, Moshe Elkabets, Kerry S. Campbell, Miri Zektser, Roi Gazit, Ory Rouvio, Frank Momburg, Angel Porgador   +16 more
doaj   +2 more sources

HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection [PDF]

Frontiers in Immunology
IntroductionTuberculosis (TB) is the deadliest infectious disease worldwide and novel vaccines are urgently needed. HLA-E is a virtually monomorphic antigen presentation molecule and is not downregulated upon HIV co-infection.
Linda Voogd, Catherine Riou, Catherine Riou, Thomas J. Scriba, Marjolein van Wolfswinkel, Krista E. van Meijgaarden, Kees L. M. C. Franken, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Tom H. M. Ottenhoff, Simone A. Joosten   +12 more
doaj   +2 more sources

HLA-E: A Novel Player for Histocompatibility [PDF]

Journal of Immunology Research, 2014
The classical class I human leukocyte antigens (HLA-A, -B, and -C) present allele-specific self- or pathogenic peptides originated by intracellular processing to CD8+ immune effector cells. Even a single mismatch in the heavy chain (hc) of an HLA class I
Thomas Kraemer, Rainer Blasczyk, Christina Bade-Doeding   +2 more
doaj   +4 more sources

Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire [PDF]

iScience
Summary: HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their T cell receptor (TCR) are termed donor-unrestricted T cells due to restricted allelic ...
Linda Voogd, Anne M.H.F. Drittij, Calinda K.E. Dingenouts, Kees L.M.C. Franken, Vincent van Unen, Krista E. van Meijgaarden, Paula Ruibal, Renate S. Hagedoorn, Judith A. Leitner, Peter Steinberger, Mirjam H.M. Heemskerk, Mark M. Davis, Thomas J. Scriba, Tom H.M. Ottenhoff, Simone A. Joosten   +14 more
doaj   +2 more sources

HLA-E-restricted SARS-CoV-2 epitopes drive CD8+ T cell memory in convalescent and vaccinated individuals: implications for the design of next-generation vaccines and immunotherapeutics [PDF]

Journal of Translational Medicine
Background Human leukocyte antigen-E (HLA-E) is a non-polymorphic, non-classical HLA class Ib molecule that presents signal peptides from classical HLA class Ia molecules to natural killer (NK) cell receptors.
Mahsa Rafieiyan, Giusto Davide Badami, Nicola Scichilone, Salvatore Corrao, Vincenzo Restivo, Enzo Massimo Farinella, Martina Bottone, Gabriella Pietra, Miriana Fallo, Andrea Maria Aglio, Marco Pio La Manna, Francesco Dieli, Mojtaba Shekarkar Azgomi, Nadia Caccamo   +13 more
doaj   +2 more sources

The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E [PDF]

Frontiers in Immunology
The commonly used antibodies 3D12 and 4D12 recognise the human leukocyte antigen E (HLA-E) protein. These antibodies bind distinct epitopes on HLA-E and differ in their ability to bind alleles of the major histocompatibility complex E (MHC-E) proteins of
Simon Brackenridge, Nessy John, Klaus Früh, Persephone Borrow, Andrew J. McMichael   +4 more
doaj   +2 more sources