Results 11 to 20 of about 183,897 (254)
Deciphering the HLA-E immunopeptidome with mass spectrometry: an opportunity for universal mRNA vaccines and T-cell-directed immunotherapies [PDF]
Frontiers in ImmunologyAdvances in immunotherapy rely on targeting novel cell surface antigens, including therapeutically relevant peptide fragments presented by HLA molecules, collectively known as the actionable immunopeptidome.
Maya Weitzen +4 more
doaj +2 more sources
The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients [PDF]
Iranian Journal of Immunology, 2022 Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important ...
Masumeh Darai +5 more
doaj +1 more source
Pathogens, 2023 Host genetic factors significantly influence susceptibility to SARS-CoV-2 infection and COVID-19 severity. Among these genetic factors are single-nucleotide variants (SNVs). IFNAR2 and IFNAR1 genes have been associated with severe COVID-19 in populations
María Fernanda López-Bielma +3 more
doaj +1 more source
Antibodies, 2022 Serum anti-HLA-I IgG are present in non-alloimmunized males, cancer patients, and transplant recipients. Anti-HLA-I antibodies are also present in intravenous immunoglobulin (IVIg), prepared from the plasma of thousands of healthy donors.
Mepur H. Ravindranath +4 more
doaj +1 more source
HLA, 2021 HLA‐E is a member of the nonclassical HLA class Ib genes. Even though it is structurally highly similar to the classical HLA class Ia genes, it is less diverse and only 45 alleles and 12 proteins were known in December 2019 (IPD‐IMGT/HLA, release 3.38.0).
Christin Paech +7 more
openaire +2 more sources
HLA-E and HLA-F Are Overexpressed in Glioblastoma and HLA-E Increased After Exposure to Ionizing Radiation [PDF]
Cancer Genomics - Proteomics, 2022 Glioblastoma (GBM) is one of the deadliest human cancers responding very poorly to therapy. Although the central nervous system has been traditionally considered an immunologically privileged site with an enhanced immune response, GBM appears to benefit from this immunosuppressive milieu.
Tomas, Hrbac +17 more
openaire +2 more sources
Journal of Biological Chemistry, 2003 The HLA-E protein is one of the most extensively studied MHC class Ib antigens and the least polymorphic one compared to other MHC class I molecules. In the human population there have been reported just ten alleles encoding three different peptides. Only two of these alleles, namely HLA-E*0101 and HLA-E*0103, are widely distributed (around 50% each ...
Roland K. Strong +5 more
+6 more sources
Bioengineering, 2023 Background: Limited graft availability is a constant clinical concern. Hence, the umbilical cord (UC) is an attractive alternative to autologous grafts.
Yue Ying Yao +7 more
doaj +1 more source
Biosafety and Health, 2023 Infection with the Hantaan virus (HTNV) may result in severe hemorrhagic fever with renal syndrome (HFRS). The functions of HLA-E-restricted CD8+ T lymphocytes in virus control and vaccine development have recently received increased attention.
Kang Tang +10 more
doaj +1 more source
ANTíGENOS HLA ESTÃO ASSOCIADOS A RISCO DE DIABETES MELLITUS PÓS-TRANSPLANTE?
Brazilian Journal of Transplantation, 2021 Introdução: Diabetes mellitus pós-transplante (DMPT) tem impacto na morbidade e na mortalidade em receptores de transplante renal, uma vez que aumenta o risco de complicações cardiovasculares e de perda do enxerto renal.
Débora Dias de Lucena +5 more
doaj +1 more source