Results 1 to 10 of about 11,789,754 (116)

Systematic Evaluation of HLA-G 3’Untranslated Region Variants in Locally Advanced, Non-Metastatic Breast Cancer Patients: UTR-1, 2 or UTR-4 are Predictors for Therapy and Disease Outcome

Frontiers in Immunology, 2022
Despite major improvements in diagnostics and therapy in early as well as in locally advanced breast cancer (LABC), metastatic relapse occurs in about 20% of patients, often explained by early micro-metastatic spread into bone marrow by disseminated ...
Vera Rebmann, Esther Schwich, Rafael Tomoya Michita, Rafael Tomoya Michita, Lisa Grüntkemeier, Ann-Kathrin Bittner, Hana Rohn, Peter A. Horn, Oliver Hoffmann, Rainer Kimmig, Sabine Kasimir-Bauer   +10 more
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Human Leukocyte Antigens in Pregnancy and Preeclampsia

Frontiers in Genetics, 2022
Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which includes underlying maternal cardiovascular disease, deficient spiral artery remodeling during placenta development, and inflammatory immune responses at the maternal-
Omonigho Aisagbonhi, Gerald P. Morris
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Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis

Frontiers in Immunology, 2022
IntroductionHLA-G plays a central role in immune tolerance at the maternal-fetal interface. The HLA-G gene is characterized by low allelic polymorphism and restricted tissue expression compared with classical HLA genes.
Lian Hu, Dongmei He, Hong Zeng, Hong Zeng   +3 more
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HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges

Frontiers in Immunology, 2021
Immune checkpoint inhibitors (ICIs) have become a promising immunotherapy for cancers. Human leukocyte antigen-G (HLA-G), a neoantigen, its biological functions and clinical relevance have been extensively investigated in malignancies, and early clinical
Aifen Lin, Aifen Lin, Wei-Hua Yan, Wei-Hua Yan   +3 more
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HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers

Frontiers in Immunology, 2021
As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it ...
Peilong Li, Peilong Li, Peilong Li, Nan Wang, Yi Zhang, Chuanxin Wang, Chuanxin Wang, Chuanxin Wang, Lutao Du, Lutao Du, Lutao Du   +10 more
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Haplotypes of the HLA-G 3' Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially. [PDF]

PLoS ONE, 2017
The immune checkpoint HLA-G prevents maternal rejection of the fetus and contributes in cancer invasion and acceptance of allografts. The 5' and 3' regulatory regions of the HLA-G gene are polymorphic and balancing selection probably maintains this ...
Isabelle Poras, Layale Yaghi, Gustavo Martelli-Palomino, Celso T Mendes-Junior, Yara Costa Netto Muniz, Natalia F Cagnin, Bibiana Sgorla de Almeida, Erick C Castelli, Edgardo D Carosella, Eduardo A Donadi, Philippe Moreau   +10 more
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First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G

Journal for ImmunoTherapy of Cancer, 2021
Background CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies.
Olivier Adotevi, François Anna, Elodie Bole-Richard, Joel LeMaoult, Marie Escande, Martin Lecomte, Jean-Marie Certoux, Philippe Souque, Francine Garnache, Pierre Langlade-Demoyen, Maria Loustau, Julien Caumartin   +11 more
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Intratumor Heterogeneity of HLA-G Expression in Cancer Lesions

Frontiers in Immunology, 2020
Signaling pathway between human leukocyte antigen (HLA)-G and immune inhibitory receptors immunoglobulin-like transcript (ILT)-2/4 has been acknowledged as one of immune checkpoints, and as a potential target for cancer immunotherapy.
Xia Zhang, Aifen Lin, Qiu-Yue Han, Jian-Gang Zhang, Qiong-Yuan Chen, Yao-Han Ye, Wen-Jun Zhou, Hui-Hui Xu, Jun Gan, Wei-Hua Yan   +9 more
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The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients [PDF]

Iranian Journal of Immunology, 2022
Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important ...
Masumeh Darai, Saeede Soleimanian, Ramin Yaghobi, Kourosh Kazemi, Saman Nikeghbalian, Negar Azarpira   +5 more
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MiRNA-mediated control of HLA-G expression and function. [PDF]

PLoS ONE, 2012
HLA-G is a non-classical HLA class-Ib molecule expressed mainly by the extravillous cytotrophoblasts (EVT) of the placenta. The expression of HLA-G on these fetal cells protects the EVT cells from immune rejection and is therefore important for a healthy
Irit Manaster, Debra Goldman-Wohl, Caryn Greenfield, Daphna Nachmani, Pinchas Tsukerman, Yaron Hamani, Simcha Yagel, Ofer Mandelboim   +7 more
doaj   +1 more source