HLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer [PDF]
Frontiers in ImmunologyIntroductionThe concept that human leukocyte antigen-G (HLA-G) expression is specifically in various malignant lesions but absent in adjacent normal tissues has been well documented, and HLA-G is acknowledged as a novel immune checkpoint.MethodsIn this ...
Xia Zhang +11 more
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The non-classical immune checkpoint HLA-G: a regulatory master switch governing tolerance, evasion, and translational frontiers [PDF]
Frontiers in OncologyHuman Leukocyte Antigen G (HLA-G), a non-classical MHC Class I molecule, plays a pivotal role in immune regulation, particularly in reproductive immunology.
Huan Liu +5 more
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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery [PDF]
Nature CommunicationsExtracellular vesicles (EVs) hold great potential as a therapeutic delivery system for cancer treatment. Here, we develop an innovative targeted drug delivery platform, human leukocyte antigen-G-VHH antibody-modified EV (α-HLA-G-EV), to enhance ...
Ming-You Shie +12 more
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Frontiers in Immunology, 2022 Despite major improvements in diagnostics and therapy in early as well as in locally advanced breast cancer (LABC), metastatic relapse occurs in about 20% of patients, often explained by early micro-metastatic spread into bone marrow by disseminated ...
Vera Rebmann +10 more
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Frontiers in Immunology, 2022 IntroductionHLA-G plays a central role in immune tolerance at the maternal-fetal interface. The HLA-G gene is characterized by low allelic polymorphism and restricted tissue expression compared with classical HLA genes.
Lian Hu +3 more
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Human Leukocyte Antigens in Pregnancy and Preeclampsia
Frontiers in Genetics, 2022 Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which includes underlying maternal cardiovascular disease, deficient spiral artery remodeling during placenta development, and inflammatory immune responses at the maternal-
Omonigho Aisagbonhi, Gerald P. Morris
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HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges
Frontiers in Immunology, 2021 Immune checkpoint inhibitors (ICIs) have become a promising immunotherapy for cancers. Human leukocyte antigen-G (HLA-G), a neoantigen, its biological functions and clinical relevance have been extensively investigated in malignancies, and early clinical
Aifen Lin +3 more
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HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
Frontiers in Immunology, 2021 As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it ...
Peilong Li +10 more
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Haplotypes of the HLA-G 3' Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially. [PDF]
PLoS ONE, 2017 The immune checkpoint HLA-G prevents maternal rejection of the fetus and contributes in cancer invasion and acceptance of allografts. The 5' and 3' regulatory regions of the HLA-G gene are polymorphic and balancing selection probably maintains this ...
Isabelle Poras +10 more
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First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
Journal for ImmunoTherapy of Cancer, 2021 Background CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies.
Olivier Adotevi +11 more
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