Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia (B-CLL).
Folia Histochemica et Cytobiologica, 2009 The expression of HLA-G was reported in certain malignancies and its role in escaping from immunosurveillance in cancers was proposed since HLA-G is a nonconventional HLA class I molecule that protects fetus from immunorecognition during pregnancy ...
M Schmitt +4 more
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HLA-G*0105N null allele encodes functional HLA-G isoforms. [PDF]
, 2005 Expression of the nonclassical HLA class I antigen, HLA-G, is associated with immune tolerance in view of its role in maintaining the fetus in utero, allowing tumor escape, and favoring graft acceptance.
Carosella, Edgardo D +4 more
core +6 more sources
HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia [PDF]
Journal of Immunology Research, 2014 Human Leukocyte Antigen-G (HLA-G) contributes to cancer cell immune escape from host antitumor responses. The clinical relevance of HLA-G in several malignancies has been reported.
Grazia Locafaro +5 more
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HLA-G high-expressor 3'UTR markers are linked to gastric cancer development and survival. [PDF]
Cancer Immunol ImmunotherVaquero-Yuste C +9 more
europepmc +3 more sources
First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
Journal for ImmunoTherapy of Cancer, 2021 Background CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies.
Olivier Adotevi +11 more
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Haplotypes of the HLA-G 3' Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially. [PDF]
PLoS ONE, 2017 The immune checkpoint HLA-G prevents maternal rejection of the fetus and contributes in cancer invasion and acceptance of allografts. The 5' and 3' regulatory regions of the HLA-G gene are polymorphic and balancing selection probably maintains this ...
Isabelle Poras +10 more
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HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
Frontiers in Immunology, 2021 As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it ...
Peilong Li +10 more
doaj +1 more source
The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients [PDF]
Iranian Journal of Immunology, 2022 Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important ...
Masumeh Darai +5 more
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Intratumor Heterogeneity of HLA-G Expression in Cancer Lesions
Frontiers in Immunology, 2020 Signaling pathway between human leukocyte antigen (HLA)-G and immune inhibitory receptors immunoglobulin-like transcript (ILT)-2/4 has been acknowledged as one of immune checkpoints, and as a potential target for cancer immunotherapy.
Xia Zhang +9 more
doaj +1 more source
MiRNA-mediated control of HLA-G expression and function. [PDF]
PLoS ONE, 2012 HLA-G is a non-classical HLA class-Ib molecule expressed mainly by the extravillous cytotrophoblasts (EVT) of the placenta. The expression of HLA-G on these fetal cells protects the EVT cells from immune rejection and is therefore important for a healthy
Irit Manaster +7 more
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