Results 21 to 30 of about 171,039 (261)

Tolerogenic function of dimeric forms of HLA-G recombinant proteins: a comparative study in vivo. [PDF]

PLoS ONE, 2011
HLA-G is a natural tolerogenic molecule involved in the best example of tolerance to foreign tissues there is: the maternal-fetal tolerance. The further involvement of HLA-G in the tolerance of allogeneic transplants has also been demonstrated and some ...
Benoit Favier, Kiave-Yune HoWangYin, Juan Wu, Julien Caumartin, Marina Daouya, Anatolij Horuzsko, Edgardo D Carosella, Joel LeMaoult   +7 more
doaj   +1 more source

Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia (B-CLL).

Folia Histochemica et Cytobiologica, 2009
The expression of HLA-G was reported in certain malignancies and its role in escaping from immunosurveillance in cancers was proposed since HLA-G is a nonconventional HLA class I molecule that protects fetus from immunorecognition during pregnancy ...
M Schmitt, A Bojarska-Junak, A Dmoszyńska, K Giannopoulos, J Roliński   +4 more
doaj   +1 more source

Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

Frontiers in Immunology, 2021
Human leukocyte antigen G (HLA-G) is known as a novel immune checkpoint molecule in cancer; thus, HLA-G and its receptors might be targets for immune checkpoint blockade in cancer immunotherapy.
Hui-Hui Xu, Hui-Hui Xu, Jun Gan, Dan-Ping Xu, Lu Li, Wei-Hua Yan, Wei-Hua Yan   +6 more
doaj   +1 more source

HLA-G Haplotypes Are Differentially Associated with Asthmatic Features

Frontiers in Immunology, 2018
Human leukocyte antigen (HLA)-G, a HLA class Ib molecule, interacts with receptors on lymphocytes such as T cells, B cells, and natural killer cells to influence immune responses.
Camille Ribeyre, Federico Carlini, Céline René, Céline René, François Jordier, François Jordier, Christophe Picard, Christophe Picard, Jacques Chiaroni, Jacques Chiaroni, Laurent Abi-Rached, Philippe Gouret, Grégory Marin, Grégory Marin, Nicolas Molinari, Nicolas Molinari, Pascal Chanez, Pascal Chanez, Julien Paganini, Delphine Gras, Julie Di Cristofaro, Julie Di Cristofaro   +21 more
doaj   +1 more source

HLA-G genetic diversity and evolutive aspects in worldwide populations

Scientific Reports, 2021
HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes.
Erick C. Castelli, Bibiana S. de Almeida, Yara C. N. Muniz, Nayane S. B. Silva, Marília R. S. Passos, Andreia S. Souza, Abigail E. Page, Mark Dyble, Daniel Smith, Gabriela Aguileta, Jaume Bertranpetit, Andrea B. Migliano, Yeda A. O. Duarte, Marília O. Scliar, Jaqueline Wang, Maria Rita Passos-Bueno, Michel S. Naslavsky, Mayana Zatz, Celso Teixeira Mendes-Junior, Eduardo A. Donadi   +19 more
doaj   +1 more source

Associations of HLA-G 3’UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis

Immunobiology
Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen
Ines Zemni, Daria Bortolotti, Sabrine Dhouioui, Sana Baroudi, Malek Ferjani, Inès Nasri, Yosr Zenzri, Md Ataur Rahman, Abdel Halim Harrath, Roberta Rizzo, Nadia Boujelbene, Inès Zidi   +11 more
doaj   +1 more source

HLA-G remains a mystery

Trends in Immunology, 2001
In this brief summary, we argue that many widely held beliefs about HLA-G are questionable. Recent research has led to a re-evaluation of many of the characteristics that were thought to make HLA-G unusual among the MHC class I molecules. First, contrary to reports suggesting that the gene encoding HLA-G exhibits marked polymorphism in some human ...
Bainbridge, D, Ellis, S, Le Bouteiller, P, Sargent, I   +3 more
openaire   +3 more sources

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

Journal of Immunology Research, 2017
The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor ...
Marica Garziera, Lucia Scarabel, Giuseppe Toffoli   +2 more
doaj   +1 more source

HLA-G: facts and fictions

Asian Pacific Journal of Cancer Biology, 2018
Human leukocyte antigen (HLA)-G is a nonclassical MHC class I molecule with modulatory effects on NK and T cells. Unlike classical HLA class I molecules, HLA-G has seven isoforms, three of which are soluble. Soluble HLA-G molecules are reportedly able to
Shirin Farjadian
doaj   +3 more sources

HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia

Journal of Immunology Research, 2014
Human Leukocyte Antigen-G (HLA-G) contributes to cancer cell immune escape from host antitumor responses. The clinical relevance of HLA-G in several malignancies has been reported.
Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori   +5 more
doaj   +1 more source