A distant trophoblast-specific enhancer controls HLA-G expression at the maternal–fetal interface [PDF]
, 2016 HLA-G, a nonclassical HLA molecule uniquely expressed in the placenta, is a central component of fetus-induced immune tolerance during pregnancy. The tissue-specific expression of HLA-G, however, remains poorly understood.
Camahort, Raymond +12 more
core +1 more source
Association of HLA-A and Non-Classical HLA Class I Alleles.
PLoS ONE, 2016 The HLA-A locus is surrounded by HLA class Ib genes: HLA-E, HLA-H, HLA-G and HLA-F. HLA class Ib molecules are involved in immuno-modulation with a central role for HLA-G and HLA-E, an emerging role for HLA-F and a yet unknown function for HLA-H.
Federico Carlini +8 more
doaj +1 more source
HLA-G Expression in Lung Adenocarcinoma Tissues and Its Relationship with Prognosis
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the expression of HLA-G and determine the prognostic value of HLA-G for lung adenocarcinoma. Methods The genomic alternation of HLA-G was analyzed using cBioPortal analytic tool.
ZHANG Wenlong +4 more
doaj +1 more source
HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction [PDF]
Advanced Pharmaceutical Bulletin, 2013 Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic ...
Elnaz Mosaferi +5 more
doaj +1 more source
HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives
Frontiers in Immunology, 2020 The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological condition, HLA-G surface expression is restricted to the maternal–fetal interface and to immune-privileged adult tissues, whereas soluble forms of HLA-G are detectable ...
Giada Amodio, Silvia Gregori
doaj +1 more source
Tolerogenic function of dimeric forms of HLA-G recombinant proteins: a comparative study in vivo. [PDF]
PLoS ONE, 2011 HLA-G is a natural tolerogenic molecule involved in the best example of tolerance to foreign tissues there is: the maternal-fetal tolerance. The further involvement of HLA-G in the tolerance of allogeneic transplants has also been demonstrated and some ...
Benoit Favier +7 more
doaj +1 more source
Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection [PDF]
, 2013 Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses.
Li, Chun +8 more
core +4 more sources
Case–control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis [PDF]
, 2012 BACKGROUND: The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown.
Anna Gillio-Tos +14 more
core +1 more source
Role of HLA-G in Viral Infections
Frontiers in Immunology, 2022 The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has distinct features to classical HLA-A, -B, -C antigens, such as a low polymorphism, different splice variants, highly restricted, tightly regulated expression and ...
Simon Jasinski-Bergner +4 more
doaj +1 more source
Immunological Compatibility Status of Placenta-Derived Stem Cells is Mediated by Scaffold 3D Structure [PDF]
, 2018 Placenta-derived amniotic epithelial cells (AECs), a great cell source for tissue engineering and stem cell therapy, are immunologically inert in their native state; however, immunological changes in these cells after culture and differentiation have ...
Azizian, Sara +8 more
core +2 more sources