Results 21 to 30 of about 11,789,754 (116)

HLA-G: Su importancia inmunológica [PDF]

, 2006
HLA-G es una molécula clase I no clásica (Ib) del Complejo Mayor de Histocompatibilidad Humano (CMH), adopta siete isoformas, resultado del empalme alternativo de un mismo RNA inmaduro, cuatro se encuentran ligadas a la membrana (HLA-G1,-G2, -G3, -G4) y ...
Verónica Rincón, Edwin Manrique, Manrique, Edwin, Rincón, Verónica   +3 more
core   +1 more source

Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

Frontiers in Immunology, 2021
Human leukocyte antigen G (HLA-G) is known as a novel immune checkpoint molecule in cancer; thus, HLA-G and its receptors might be targets for immune checkpoint blockade in cancer immunotherapy.
Hui-Hui Xu, Hui-Hui Xu, Jun Gan, Dan-Ping Xu, Lu Li, Wei-Hua Yan, Wei-Hua Yan   +6 more
doaj   +1 more source

HLA-G UTR haplotype conservation in the Malian population: association with soluble HLA-G. [PDF]

PLoS ONE, 2013
The HLA-G molecule plays an important role in immunomodulation. In a previous study carried out on a southern French population our team showed that HLA-G haplotypes, defined by SNPs in the coding region and specific SNPs located in 5'URR and 3'UTR ...
Federico Carlini, Karim Traore, Nissem Cherouat, Pierre Roubertoux, Stéphane Buhler, Martì Cortey, Sophie Simon, Ogobara Doumbo, Jacques Chiaroni, Christophe Picard, Julie Di Cristofaro   +10 more
doaj   +1 more source

Associations of HLA-G 3’UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis

Immunobiology
Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen
Ines Zemni, Daria Bortolotti, Sabrine Dhouioui, Sana Baroudi, Malek Ferjani, Inès Nasri, Yosr Zenzri, Md Ataur Rahman, Abdel Halim Harrath, Roberta Rizzo, Nadia Boujelbene, Inès Zidi   +11 more
doaj   +1 more source

HLA-G Haplotypes Are Differentially Associated with Asthmatic Features

Frontiers in Immunology, 2018
Human leukocyte antigen (HLA)-G, a HLA class Ib molecule, interacts with receptors on lymphocytes such as T cells, B cells, and natural killer cells to influence immune responses.
Camille Ribeyre, Federico Carlini, Céline René, Céline René, François Jordier, François Jordier, Christophe Picard, Christophe Picard, Jacques Chiaroni, Jacques Chiaroni, Laurent Abi-Rached, Philippe Gouret, Grégory Marin, Grégory Marin, Nicolas Molinari, Nicolas Molinari, Pascal Chanez, Pascal Chanez, Julien Paganini, Delphine Gras, Julie Di Cristofaro, Julie Di Cristofaro   +21 more
doaj   +1 more source

HLA-G genetic diversity and evolutive aspects in worldwide populations

Scientific Reports, 2021
HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes.
Erick C. Castelli, Bibiana S. de Almeida, Yara C. N. Muniz, Nayane S. B. Silva, Marília R. S. Passos, Andreia S. Souza, Abigail E. Page, Mark Dyble, Daniel Smith, Gabriela Aguileta, Jaume Bertranpetit, Andrea B. Migliano, Yeda A. O. Duarte, Marília O. Scliar, Jaqueline Wang, Maria Rita Passos-Bueno, Michel S. Naslavsky, Mayana Zatz, Celso Teixeira Mendes-Junior, Eduardo A. Donadi   +19 more
doaj   +1 more source

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

Journal of Immunology Research, 2017
The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor ...
Marica Garziera, Lucia Scarabel, Giuseppe Toffoli   +2 more
doaj   +1 more source

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Gekeler, V., Müller, C. A., Engler-Blum, G., Steiert, I., Weiss, Elisabeth H., Schmidt, H.   +5 more
core   +1 more source

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source

HLA-A~HLA-H~ HLA-G UTRs haplotypes with a frequency greater than 1%.

, 2016
HLA-A~HLA-H~ HLA-G UTRs haplotypes with a frequency greater than 1%.
Julie Di Cristofaro (473988), Jacques Chiaroni (473993), Audrey Tous (3192987), Stéphane Buhler (149592), Virginia Ferreira (3192984), Céline René (10829), Jean-François Eliaou (273686), Federico Carlini (501365), Christophe Picard (501369)   +8 more
core   +1 more source