Results 31 to 40 of about 180,590 (201)

Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

Frontiers in Immunology, 2021
Human leukocyte antigen G (HLA-G) is known as a novel immune checkpoint molecule in cancer; thus, HLA-G and its receptors might be targets for immune checkpoint blockade in cancer immunotherapy.
Hui-Hui Xu, Hui-Hui Xu, Jun Gan, Dan-Ping Xu, Lu Li, Wei-Hua Yan, Wei-Hua Yan   +6 more
doaj   +1 more source

Linking Two Immuno-Suppressive Molecules: Indoleamine 2,3 Dioxygenase Can Modify HLA-G Cell-Surface Expression1 [PDF]

, 2005
Nonclassical human leukocyte antigen (HLA) class I molecule HLA-G and indoleamine 2,3 dioxygenase (INDO) in humans and mice, respectively, have been shown to play crucial immunosuppressive roles in fetal-maternal tolerance.
Alegre-Martinez, E. (Estibaliz), Carosella, E.D. (Edgardo D.), Caumartin, J. (Julien), Daouya, M. (Marina), Gonzalez-Hernandez, A. (Alvaro), Le-Rond, S. (Solene), LeMaoult, J. (Joël), Lopez, A. (Ana), Moreau, P. (Philippe)   +8 more
core   +1 more source

HLA-G Haplotypes Are Differentially Associated with Asthmatic Features

Frontiers in Immunology, 2018
Human leukocyte antigen (HLA)-G, a HLA class Ib molecule, interacts with receptors on lymphocytes such as T cells, B cells, and natural killer cells to influence immune responses.
Camille Ribeyre, Federico Carlini, Céline René, Céline René, François Jordier, François Jordier, Christophe Picard, Christophe Picard, Jacques Chiaroni, Jacques Chiaroni, Laurent Abi-Rached, Philippe Gouret, Grégory Marin, Grégory Marin, Nicolas Molinari, Nicolas Molinari, Pascal Chanez, Pascal Chanez, Julien Paganini, Delphine Gras, Julie Di Cristofaro, Julie Di Cristofaro   +21 more
doaj   +1 more source

HLA-G genetic diversity and evolutive aspects in worldwide populations

Scientific Reports, 2021
HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes.
Erick C. Castelli, Bibiana S. de Almeida, Yara C. N. Muniz, Nayane S. B. Silva, Marília R. S. Passos, Andreia S. Souza, Abigail E. Page, Mark Dyble, Daniel Smith, Gabriela Aguileta, Jaume Bertranpetit, Andrea B. Migliano, Yeda A. O. Duarte, Marília O. Scliar, Jaqueline Wang, Maria Rita Passos-Bueno, Michel S. Naslavsky, Mayana Zatz, Celso Teixeira Mendes-Junior, Eduardo A. Donadi   +19 more
doaj   +1 more source

Expression of HLA-G in inflammatory bowel disease provides a potential way to distinguish between ulcerative colitis and Crohn's disease. [PDF]

, 2004
In addition to being involved in nutrient uptake, the epithelial mucosa constitute the first line of defense against microbial pathogens. A direct consequence of this physiological function is a very complex network of immunological interactions that ...
Carosella, E. D., Dausset, J., Gassull, M. A., Gil, A., Le Discorde, Magali, Lorite, P., Maldonado, J., Ríos, A., Torres, M. I.   +8 more
core   +4 more sources

Associations of HLA-G 3’UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis

Immunobiology
Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen
Ines Zemni, Daria Bortolotti, Sabrine Dhouioui, Sana Baroudi, Malek Ferjani, Inès Nasri, Yosr Zenzri, Md Ataur Rahman, Abdel Halim Harrath, Roberta Rizzo, Nadia Boujelbene, Inès Zidi   +11 more
doaj   +1 more source

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

Journal of Immunology Research, 2017
The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor ...
Marica Garziera, Lucia Scarabel, Giuseppe Toffoli   +2 more
doaj   +1 more source

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity [PDF]

, 2014
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function of class I non-classical genes.
Audrey eSabbagh, Audrey eSabbagh, Celso T Mendes-Junior, Eduardo A Donadi, Erick C Castelli, Iane O.P. Porto, Jaqueline eRamalho, Leandro P Felício, Thálitta H.A. Lima   +8 more
core   +2 more sources

HLA-G: facts and fictions

Asian Pacific Journal of Cancer Biology, 2018
Human leukocyte antigen (HLA)-G is a nonclassical MHC class I molecule with modulatory effects on NK and T cells. Unlike classical HLA class I molecules, HLA-G has seven isoforms, three of which are soluble. Soluble HLA-G molecules are reportedly able to
Shirin Farjadian
doaj   +3 more sources

HLA-G UTR haplotype conservation in the Malian population: association with soluble HLA-G. [PDF]

PLoS ONE, 2013
The HLA-G molecule plays an important role in immunomodulation. In a previous study carried out on a southern French population our team showed that HLA-G haplotypes, defined by SNPs in the coding region and specific SNPs located in 5'URR and 3'UTR ...
Federico Carlini, Karim Traore, Nissem Cherouat, Pierre Roubertoux, Stéphane Buhler, Martì Cortey, Sophie Simon, Ogobara Doumbo, Jacques Chiaroni, Christophe Picard, Julie Di Cristofaro   +10 more
doaj   +1 more source