Results 41 to 50 of about 180,590 (201)

Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis.

, 2013
International audienceBACKGROUND AND AIMS: Infection by hepatitis C virus is a worldwide health problem. An inadequate Th2 cytokine response promotes the fibrosis-cirrhosis fate. Immune-modulating molecules favoring a Th2 profile, such as HLA-G molecules
Amiot, Laurence, Chalmel, Frédéric, Gascan, Hugues, Guyader, Dominique, Helgoualc'H, Annie L', Rauch, Michel, Samson, Michel, Turlin, Bruno, Vu, Nicolas   +8 more
core   +3 more sources

HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

Journal of Immunology Research, 2014
HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft.
Vera Rebmann, Fabiola da Silva Nardi, Bettina Wagner, Peter A. Horn   +3 more
doaj   +1 more source

Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL [PDF]

, 2012
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus.
Angioni, Antonis Makrigiannakis, Barnea, Birgit Bayer, Borges, Chieppa, Dace, Darius Dian, David Anz, Devaraj, Dockrell, Gordon, Gustafsson, Heikkinen, Houser, Iordanis Navrozoglou, Julia Knabl, Klaus Friese, Macklon, Makrigiannakis, Mills, Minas, Miwa, Mizuno, Munn, Nagamatsu, Nagata, Parhar, Pestka, Piccinni, Quack, Renaud, Sabine Guenther, Sabine Heublein, Saito, Sica, Thomas Vrekoussis, Udo Jeschke, Vassiliadou, Warning, Wongweragiat, Yagel   +41 more
core   +2 more sources

Targeting Dual Immune Checkpoints PD-L1 and HLA-G by Trispecific T Cell Engager for Treating Heterogeneous Lung Cancer. [PDF]

Adv Sci (Weinh)
Lin YC, Chen MC, Huang SW, Chen Y, Ho JH, Lin FY, Tan XT, Chiang HC, Huang CC, Tu CY, Cho DY, Chiu SC.   +11 more
europepmc   +3 more sources

HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia [PDF]

, 2017
Preeclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify dysregulated genes in maternal whole blood samples which may be ...
Akehurst, Christine, Carty, David M., Delles, Christian, Freeman, Dilys J., McBride, Martin W., McClure, John D., Robinson, Scott W., Sharafetdinova, Lilya, Small, Heather Y.   +8 more
core   +1 more source

Evolution of the levels of human leukocyte antigen G (HLA-G) in Beninese infant during the first year of life in a malaria endemic area : using latent class analysis [PDF]

, 2016
Background: HLA-G, a non-classical HLA class I antigen, is of crucial interest during pregnancy by inhibiting maternal immune response. Its role during infections is discussed, and it has been described that high levels of soluble HLA-G during childhood ...
Cottrell, Gilles, Courtin, David, d'Almeida, T. C., Donadi, E. A., Favier, B., Garcia, André, Massougbodji, A., Moreau, P., Moutairou, K., Rouass-Freiss, N., Sadissou, I., Tahar, Rachida   +11 more
core  

Characterization of the expression and immunological impact of the transcriptional activator CREB in renal cell carcinoma

Journal of Translational Medicine, 2020
Background The non-classical human leukocyte antigen (HLA)-G is a strong immunomodulatory molecule. Under physiological conditions, HLA-G induces immunological tolerance in immune privileged tissues, while under pathophysiological situations it ...
Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven, Barbara Seliger   +7 more
doaj   +1 more source

Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Frontiers in Immunology, 2023
Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the
Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, Ping Li   +12 more
doaj   +1 more source

Non melanoma skin cancer pathogenesis overview [PDF]

, 2018
(1)Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood.
Bottoni Ugo, Cantisani Carmen, Didona Dario, Paolino Giovanni   +3 more
core   +1 more source

The role of HLA-G molecule and HLA-G gene polymorphisms in tumors, viral hepatitis and parasitic diseases

Frontiers in Immunology, 2015
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas HLA-G expression is expected to
Fabrício César Dias, Erick C. Castelli, Cristhianna Viesti Advincula Collares, Philippe eMoreau, Eduardo Antonio Donadi   +4 more
doaj   +1 more source