Results 21 to 30 of about 10,792,655 (300)

Direct identification of HLA class I and class II-restricted T cell epitopes in pancreatic cancer tissues by mass spectrometry

Journal of Hematology & Oncology, 2022
Background Identifying T cell epitopes on pancreatic ductal adenocarcinoma (PDAC) associated antigens or neoantigens has been a challenge. In this study, we attempted to identify PDAC T cell epitopes by mass spectrometry (MS).
Kenji Fujiwara, Yingkuan Shao, Nan Niu, Tengyi Zhang, Brian Herbst, Mackenzie Henderson, Stephen Muth, Pingbo Zhang, Lei Zheng   +8 more
doaj   +1 more source

Non-HLA Genetics and Application to Living Donor Candidates. [PDF]

Curr Transplant Rep
This review examines the expanding role of non-human leukocyte antigen (non-HLA) genetic factors in kidney transplantation, with a particular focus on their implications for living donor evaluation and outcomes. It emphasizes the potential of genetic testing to improve risk stratification beyond conventional HLA matching, especially for donor ...
Caliskan Y, Afsar B, Afsar RE, Varma C, Aygormez O, Lentine KL.   +5 more
europepmc   +3 more sources

Novel insights into non‐HLA alloimmunity in kidney transplantation [PDF]

Transplant International, 2019
Recognition of non-self structures on donor cells represents the main immunological barrier in solid organ transplantation. The human leukocyte antigens (HLA) are considered the most important non-self (allo)antigens in transplantation. Long-term graft attrition is mainly caused by the formation of alloreactive antibodies that are directed against non ...
Roman Reindl‐Schwaighofer, Andreas Heinzel, Guido A. Gualdoni, Laurent Mesnard, Frans H.J. Claas, Rainer Oberbauer   +5 more
openaire   +4 more sources

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Antibodies, 2022
Serum anti-HLA-I IgG are present in non-alloimmunized males, cancer patients, and transplant recipients. Anti-HLA-I antibodies are also present in intravenous immunoglobulin (IVIg), prepared from the plasma of thousands of healthy donors.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Fatiha El Hilali, Senthamil R. Selvan, Edward J. Filippone   +4 more
doaj   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Tabaczewski, P., Pohla, Heike, Heike Pohla, Kuon, W., Wolfgang Kuon, Piotr Tabaczewski, Doerner, C., Weiss, Elisabeth H., Christa Doerner, Elisabeth H. Weiss   +9 more
core   +1 more source

The Multifaceted Role of Non-human Leukocyte Antigens’ Immune Response in Renal Allograft Rejection

Saudi Journal of Kidney Diseases and Transplantation, 2021
In renal transplantation (RT), human leukocyte antigens (HLA) expressed on donor cells are the principal targets of the recipient’s immune system. In addition to classical HLA-alloantibodies, the importance of non-HLA antibodies (Abs) in RT is being ...
Praveen Kumar Etta, Thatipamula Madhavi, Namrata Parikh   +2 more
doaj   +1 more source

Non-HLA Genes and Multiple Sclerosis

The Open Biotechnology Journal, 2023
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. Identification of genetic variants that pose risks to MS is of high interest since they contribute largely to disease pathogenesis. A rich body of literature associated these risks with variants of HLA genes located mostly on the short arm of chromosome 6 ...
Jamilah Borjac, Alaa Matar, Maxime Merheb, Cijo George Vazhappilly, Rachel Matar   +4 more
openaire   +1 more source

HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy [PDF]

, 2008
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258
Battegay, Manuel, Günthard, Huldrych F, Gaudieri, S., Swiss, HIV Cohort Study, John, Mina, Nolan, David, James, Ian, Furrer, H, Schmid, P, Battegay, M., McKinnon, E, Rauch, A., Swiss HIV Cohort Study, ., McKinnon, E., Telenti, A, Günthard, Huldrych F., Schmid, Patrick, Rauch, A, John, M., James, I, Furrer, Hansjakob, Hirschel, Bernard, Telenti, Amalio, Schmid, P., Furrer, H., Rauch, Andri, John, M, Günthard, H.F., Mallal, Simon, Telenti, A., McKinnon, Elizabeth, Nolan, D., Günthard, H F, Hirschel, B, Günthard, H. F., Battegay, M, Hirschel, B., Nolan, D, Mallal, S, James, I., Gaudieri, Silvana, Mallal, S., Gaudieri, S, John M, Battegay M, James I, Nolan D, Gaudieri S, Rauch A, Mallal S, Schmid P, Telenti A, Furrer H, McKinnon E, Hirschel B, Günthard HF   +55 more
core   +2 more sources

The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein [PDF]

, 1992
An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated.
Honka, Thomas, Johnson, Judith P., Ulbrecht, Matthias, Person, Susanne, Weiss, Elisabeth H.   +4 more
core   +1 more source

Non-HLA genetic mismatches and BMT outcome [PDF]

Blood, 2018
In this issue of Blood, Zhu et al identify a novel rare genotype mismatch in the testis-expressed gene TEX38 that is prognostic of blood and marrow transplant (BMT) mortality (see figure).1 The single-nucleotide polymorphism (SNP) that was identified (rs200092801) in this first of its kind exome-wide association study (EXWAS) is a nonsynonymous variant,
openaire   +2 more sources