Results 31 to 40 of about 10,792,655 (300)

The role of HLA-B27 in inflammatory arthritis [PDF]

, 2009
Redacted electronic version excludes material for which permission has not been granted by the rights holderThe MHC class I allele, HLA-B27, is strongly associated with a group of inflammatory arthritic conditions collectively known as ...
Lynch, Sarah Janice
core   +2 more sources

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source

A review of the genetics of type I diabetes

Exploration of Immunology
Type I diabetes susceptibility is caused by both environmental and genetic factors, the latter comprising approximately half of the total risk as evidenced by the fact that identical twins have approximately 50% concordance, suggesting 50% of the disease
Brian D. Tait
doaj   +1 more source

High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis

Journal of Translational Medicine, 2011
Background Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that can be stabilized by ligands donated by other classical (HLA-A, -B, -C) and non-classical (HLA-G) family members.
Monaco Elisa Lo, Sperduti Isabella, Ercolani Cristiana, Diodoro Maria Grazia, Rollo Francesca, Tremante Elisa, Mottolese Marcella, Benevolo Maria, Cosimelli Maurizio, Giacomini Patrizio   +9 more
doaj   +1 more source

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Rizwan Hamer, Imray, C. (Chris), Nithya S Krishnan, Lam Chin Tan, Higgins Robert M., Daga Sunil, Lowe, David Philip, David Briggs, Zehnder Daniel, Tan Lam Chin, Zehnder, Daniel, Robert M Higgins, Daniel Zehnder, Kashi Habib, Dave Lowe, Christopher Imray, Sunil Daga, Neil Raymond, Krishnan, Nithya S., Lam, F. T., Higgins, Rob, Lam F. T., Habib Kashi, Daga, Sunil, F T Lam, Krishnan Nithya S., Lowe Dave, Hamer, Rizwan, Briggs David, Kashi, Habib, Briggs, David, Dr., Raymond Neil, Raymond, Neil T., Hamer Rizwan, Tan, Lam Chin, Imray Christopher   +35 more
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Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity? [PDF]

, 2006
Background: There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied.
Smith, AD, Horton Roger, Barnardo Martin CNM, Stephan Beck, Warden Donald R, Warden, DR, Martin CNM Barnardo, Barnetson, L, Smith A David, Andrew Sutherland, Lehmann, DJ, Beck Stephan, Isabel Quiroga, Fuggle Susan, Barnetson Lin, Barnardo, MCNM, Quiroga Isabel, Lehmann Donald J, Roger Horton, Beck, S, Susan Fuggle, Donald R Warden, Fuggle, S, Sutherland Andrew, Sutherland, A, Donald J Lehmann, Lin Barnetson, A David Smith, Quiroga, I, Horton, R   +29 more
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Brain Correlates of Human Leukocyte Antigen (HLA) Protection in Gulf War Illness (GWI)

EBioMedicine, 2016
Background: We recently reported that six alleles from class II genes of the Human Leukocyte Antigen (HLA) confer protection from Gulf War Illness (GWI) (Georgopoulos et al., 2015).
Lisa M. James, Brian E. Engdahl, Arthur C. Leuthold, Apostolos P. Georgopoulos   +3 more
doaj   +1 more source

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by D94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis [PDF]

, 1998
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I ...
John E. Coligan, Matthias Ulbrecht, Ulbrecht, Matthias, Coligan, John E., Andrew G. Brooks, Brooks, AG, Borrego, F, Coligan, JE, Elisabeth H. Weiss, Brooks, Andrew G., Francisco Borrego, Borrego, Francisco, Weiss, Elisabeth H., Ulbrecht, M, Weiss, EH   +14 more
core   +1 more source

Non-HLA Antibodies in Kidney Transplantation: Pathogenesis, Clinical Impact, and Management Approaches

Transplantology
Antibody-mediated rejection is a critical factor in acute and chronic allograft rejection, with Human Leukocyte Antigen as the primary target of the humoral immune response in kidney transplants.
Vikash Chandra Mishra, Dinesh Chandra, Vimarsh Raina   +2 more
doaj   +1 more source

The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor. [PDF]

PLoS ONE, 2016
Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex (HLA) through the T-cell receptor (TCR).
Estefanía García-Guerrero, José Antonio Pérez-Simón, Luis Ignacio Sánchez-Abarca, Irene Díaz-Moreno, Miguel A De la Rosa, Antonio Díaz-Quintana   +5 more
doaj   +1 more source