Results 51 to 60 of about 10,792,655 (300)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Selective Upregulation of CTLA-4 on CD8+ T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection.

PLoS Pathogens, 2020
HLA-B*35Px is associated with HIV-1 disease rapid progression to AIDS. However, the mechanism(s) underlying this deleterious effect of this HLA allele on HIV-1 infection outcome has not fully understood.
Shokrollah Elahi, Shima Shahbaz, Stan Houston   +2 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Identifying genetically predisposed type 1 diabetes mellitus individuals in a Southern Brazilian population: The construction of a genetic risk score [PDF]

Genetics and Molecular Biology
Single nucleotide polymorphisms (SNPs) in the HLA DR/DQ region have the greatest impact on susceptibility to type 1 diabetes mellitus (T1DM). Non-HLA SNPs interact with the HLA, influencing the risk for T1DM.
Felipe Mateus Pellenz, Mayara Souza de Oliveira, Guilherme Coutinho Kullmann Duarte, Natália Emerim Lemos, Cristine Dieter, Luís Henrique Canani, Taís Silveira Assmann, Daisy Crispim   +7 more
doaj   +1 more source

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes. [PDF]

PLoS ONE, 2017
Genetic predisposition could be assumed to be causing clustering of autoimmunity in individuals and families. We tested whether HLA and non-HLA loci associate with such clustering of autoimmunity.
Anna Parkkola, Antti-Pekka Laine, Markku Karhunen, Taina Härkönen, Samppa J Ryhänen, Jorma Ilonen, Mikael Knip, Finnish Pediatric Diabetes Register   +7 more
doaj   +1 more source

The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Analysis

Frontiers in Immunology, 2021
T-cell epitope matching according to the TCE3 algorithm classifies HLA-DPB1 mismatches in permissive and non-permissive. This classification has been shown to be predictive for mortality and acute GvHD (aGvHD) events in large international cohorts.
Daphne Mytilineos, Daphne Mytilineos, Daphne Mytilineos, Chrysanthi Tsamadou, Chrysanthi Tsamadou, Christine Neuchel, Christine Neuchel, Uwe Platzbecker, Donald Bunjes, Natalie Schub, Eva Wagner-Drouet, Gerald Wulf, Nicolaus Kröger, Niels Murawski, Hermann Einsele, Kerstin Schaefer-Eckart, Sebastian Freitag, Jochen Casper, Martin Kaufmann, Mareike Dürholt, Bernd Hertenstein, Stefan Klein, Mark Ringhoffer, Carlheinz R. Mueller, Carlheinz R. Mueller, Sandra Frank, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Fuerst, Daniel Fuerst, Joannis Mytilineos, Joannis Mytilineos, Joannis Mytilineos   +32 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes

Frontiers in Immunology
Variation within the non-coding genome may influence the regulation and expression of important genes involved in immune control such as the human leukocyte antigen (HLA) system.
Thilona Arumugam, Theolan Adimulam, Anmol Gokul, Veron Ramsuran, Veron Ramsuran   +4 more
doaj   +1 more source

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study [PDF]

, 2009
Background: Mounting evidence indicates that HLA-mediated HIV evolution follows highly stereotypic pathways that result in HLA-associated footprints in HIV at the population level.
Santiago Avila-Rios, Avila-Rios, S., Brumme, Z.L., Espinosa Enrique, Carlson, J.M., Valenzuela-Ponce Humberto, Carlson Jonathan M, John Mina, Ormsby Christopher E, David Heckerman, Heckerman, D., Juan Blanco-Heredia, Blanco-Heredia Juan, Mallal Simon, Brumme Zabrina L, Daniela Garrido-Rodriguez, Espinosa, E., Enrique Espinosa, Reyes-Teran Gustavo, Garrido-Rodriguez, D., Ormsby, C.E., Valenzuela-Ponce, H., Garcia-Morales Claudia, Zabrina L Brumme, John, M., Heckerman David, Simon Mallal, Gustavo Reyes-Teran, Claudia Garcia-Morales, Christopher E Ormsby, Humberto Valenzuela-Ponce, Garrido-Rodriguez Daniela, Avila-Rios Santiago, Mina John, Garcia-Morales, C., Jonathan M Carlson, Reyes-Teran, G., Blanco-Heredia, J., Mallal, S.   +38 more
core   +1 more source