Results 31 to 40 of about 11,147,122 (280)

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Gekeler, V., Müller, C. A., Engler-Blum, G., Steiert, I., Weiss, Elisabeth H., Schmidt, H.   +5 more
core   +1 more source

Profiling non-HLA antibody responses in antibody-mediated rejection following heart transplantation [PDF]

American Journal of Transplantation, 2020
Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor human leukocyte antigen (HLA) is a major risk factor for graft loss in cardiac transplantation. Recently, the relevance of non-HLA antibodies has become more prominent as AMR can be diagnosed in the absence of circulating DSA.
Sarah B. See, Benjamin S. Mantell, Kevin J. Clerkin, Bryan Ray, E.Rodica Vasilescu, Charles C. Marboe, Yoshifumi Naka, Susan Restaino, Paolo C. Colombo, Linda J. Addonizio, Maryjane A. Farr, Emmanuel Zorn   +11 more
openaire   +2 more sources

Cutting through the weeds: Evaluation of a novel adsorption with crossmatch cells and elution protocol to sharpen HLA antibody identification by the single antigen bead assay

Frontiers in Genetics, 2022
The single antigen bead (SAB) assay is the most used test for the identification of HLA specific antibodies pre- and post-transplant. Nevertheless, detection of spurious reactivities remains a recognized assay limitation.
Robert S. Liwski, Sandra Tafulo, Robert Carroll, Robert Carroll, James H. Lan, Anna L. Greenshields   +5 more
doaj   +1 more source

Inflammatory bowel disease-specific autoantibodies in HLA-B27-associated spondyloarthropathies: Increased prevalence of ASCA and pANCA [PDF]

, 2004
Aims: An association between inflammatory bowel disease (IBD) and spondyloarthropathies (SpA) has repeatedly been reported. The aim of the present study was to investigate whether serologic markers of IBD, e. g.
Folwaczny, Christian, Kellner, H., J. Glas, Marker-Hermann, E., R. Gruber, Brumberger, V., V. Brumberger, Glas, J., Gruber, R., H. Kellner, C. Folwaczny, Török, H.-P., E. Märker-Hermann, C. Strasser, Strasser, C., H.-P. Török   +15 more
core   +1 more source

Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients

Frontiers in Immunology, 2018
The best treatment for patients with end-stage renal disease is kidney transplantation. Although graft survival rates have improved in the last decades, patients still may lose their grafts partly due to the detrimental effects of donor-specific ...
Elena G. Kamburova, Tineke Kardol-Hoefnagel, Bram W. Wisse, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Eric Spierings, Cornelis E. Hack, Franka E. van Reekum, Arjan D. van Zuilen, Marianne C. Verhaar, Michiel L. Bots, Adriaan C. A. D. Drop, Loes Plaisier, Jan Meeldijk, Niels Bovenschen, Niels Bovenschen, Marc A. J. Seelen, Jan Stephan Sanders, Bouke G. Hepkema, Annechien J. A. Lambeck, Laura B. Bungener, Caroline Roozendaal, Marcel G. J. Tilanus, Christina E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Mariëlle A. C. J. Gelens, Maarten H. L. Christiaans, Frans J. van Ittersum, Shaikh A. Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A. M. I. van der Pant, Neelke C. van der Weerd, Ineke J. M. ten Berge, Frederike J. Bemelman, Paul J. M. van der Boog, Johan W. de Fijter, Michiel G. H. Betjes, Sebastiaan Heidt, Dave L. Roelen, Frans H. Claas, Henny G. Otten   +45 more
doaj   +1 more source

HLA diversity in ethnic populations can affect detection of donor-specific antibodies by single antigen beads

Frontiers in Immunology, 2023
IntroductionIn solid-organ transplantation, human leukocyte antigen (HLA) donor-specific antibodies (DSA) are strongly associated with graft rejection, graft loss, and patient death. The predominant tests used for detecting HLA DSA before and after solid-
Justin C. Quon, Kelli Kaneta, Nicholas Fotiadis, Jondavid Menteer, Jondavid Menteer, Rachel M. Lestz, Rachel M. Lestz, Molly Weisert, Molly Weisert, Lee Ann Baxter-Lowe, Lee Ann Baxter-Lowe   +10 more
doaj   +1 more source

The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein [PDF]

, 1992
An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated.
Honka, Thomas, Johnson, Judith P., Ulbrecht, Matthias, Person, Susanne, Weiss, Elisabeth H.   +4 more
core   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Tabaczewski, P., Pohla, Heike, Heike Pohla, Kuon, W., Wolfgang Kuon, Piotr Tabaczewski, Doerner, C., Weiss, Elisabeth H., Christa Doerner, Elisabeth H. Weiss   +9 more
core   +1 more source

Antibodies in Transplantation: The Effects of HLA and Non-HLA Antibody Binding and Mechanisms of Injury [PDF]

, 2013
Until recently, allograft rejection was thought to be mediated primarily by alloreactive T cells. Consequently, immunosuppressive approaches focused on inhibition of T cell activation. While short-term graft survival has significantly improved and rejection rates have dropped, acute rejection has not been eliminated and chronic rejection remains the ...
Nicole M, Valenzuela, Elaine F, Reed
openaire   +2 more sources

Challenges and opportunities in bringing non-HLA antibody testing for post-transplant monitoring

Frontiers in Transplantation
Evidence for the contribution of non-HLA antibodies on long-term allograft outcome was suggested in early studies by Paul Terasaki and colleagues who showed worse 10-year allograft outcome in HLA identical kidney transplant recipients with a positive ...
Mary Carmelle Philogene, Inna Tchoukina, Idoia Gimferrer   +2 more
doaj   +1 more source