Results 41 to 50 of about 11,147,122 (280)

The Multifaceted Role of Non-human Leukocyte Antigens’ Immune Response in Renal Allograft Rejection

Saudi Journal of Kidney Diseases and Transplantation, 2021
In renal transplantation (RT), human leukocyte antigens (HLA) expressed on donor cells are the principal targets of the recipient’s immune system. In addition to classical HLA-alloantibodies, the importance of non-HLA antibodies (Abs) in RT is being ...
Praveen Kumar Etta, Thatipamula Madhavi, Namrata Parikh   +2 more
doaj   +1 more source

Epidemiology and immunogenetic background of islet cell antibody - positive nondiabetic schoolchildren : Ulm-Frankfurt population study [PDF]

, 1991
Islet cell antibodies (ICAs) were determined in a large cohort of white nondiabetic schoolchildren (n = 4287) from a homogenous population in southern Germany.
Glück, Michael, Schöffling, Karl, Trucco, Massimo, Seißler, Jochen, Böhm, Bernhard Otto, Holzberger, G., Scherbaum, Werner A., Seidl, S., Manfras, Burkhard J., Kühnl, Peter   +9 more
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Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source

Evaluating the Clinical Relevance of Antibodies against Non-Human Leukocyte Antigen in Kidney Transplantation

Antibodies
Introduction: Kidney transplantation is the preferred modality of kidney replacement therapy for eligible patients with end-stage kidney disease (ESKD), given that it has been found to reduce mortality rates, improve quality of life, and is cost ...
Shiv Bhutani, Shelley Harris, Michelle Carr, Marcus Russell-Lowe, Judith Worthington, Henry H. L. Wu, Rajkumar Chinnadurai, Kay Poulton   +7 more
doaj   +1 more source

Extracellular Vesicles Mediate Immune Responses to Tissue-Associated Self-Antigens: Role in Solid Organ Transplantations

Frontiers in Immunology, 2022
Transplantation is a treatment option for patients diagnosed with end-stage organ diseases; however, long-term graft survival is affected by rejection of the transplanted organ by immune and nonimmune responses.
Ranjithkumar Ravichandran, Sandhya Bansal, Mohammad Rahman, Angara Sureshbabu, Narendra Sankpal, Timothy Fleming, Ankit Bharat, Thalachallour Mohanakumar   +7 more
doaj   +1 more source

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by D94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis [PDF]

, 1998
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I ...
John E. Coligan, Matthias Ulbrecht, Ulbrecht, Matthias, Coligan, John E., Andrew G. Brooks, Brooks, AG, Borrego, F, Coligan, JE, Elisabeth H. Weiss, Brooks, Andrew G., Francisco Borrego, Borrego, Francisco, Weiss, Elisabeth H., Ulbrecht, M, Weiss, EH   +14 more
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Chronic lung allograft dysfunction is associated with an increased number of non-HLA antibodies

, 2023
International audienceBackground: Chronic lung allograft dysfunction (CLAD) is the major cause of adverse outcomes in lung transplant recipients. Multiple factors, such as infection, alloimmunity, and autoimmunity, may lead to CLAD.
Narula, Tathagat, Hiho, Steven, Taupin, Jean-Luc, Elrefaei, Mohamed, Levvey, Bronwyn, Snell, Gregory, Belousova, Natalia, Gareau, Alison, Iasella, Carlo, Marrari, Marilyn, Levine, Deborah, Hitchman, Kelley M.K., Alvarez, Francisco, Xu, Qingyong, Bettinotti, Maria, Sanchez, Pablo, Westall, Glen, Zeevi, Adriana, Roux, Antoine   +18 more
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THE ROLE OF PRE-TRANSPLANT AND DE NOVO ALLOANTIBODIES IN KIDNEY TRANSPLANTATION

Вестник трансплантологии и искусственных органов, 2011
Kidney transplant recipients may have pre-transplant alloantibodies or develop de novo anti-HLA and non- HLA antibodies after transplantation. Although these antibodies may be donor-specific or non-donor-specific, their presence may increase the risk for
A. I. Sushkov, V. Y. Abramov, Y. G. Moysyuk   +2 more
doaj   +1 more source

Sex-Specific Differences in HLA Antibodies after Pneumococcal Vaccination in Kidney Transplant Recipients

Vaccines, 2019
In transplant recipients vaccination against Streptococcus pneumoniae is recommended to reduce mortality from invasive pneumococcal disease. It is still debated if vaccination in transplant recipients triggers alloresponses.
Monika Lindemann, Simon Oesterreich, Benjamin Wilde, Ute Eisenberger, Nils Muelling, Peter A. Horn, Falko M. Heinemann, Oliver Witzke   +7 more
doaj   +1 more source

Extended genomic HLA typing identifies previously unrecognized mismatches in living kidney transplantation

Frontiers in Immunology, 2023
IntroductionAntibody mediated rejection (ABMR) is the most common cause of long-term allograft loss in kidney transplantation (KT). Therefore, a low human leukocyte antigen (HLA) mismatch (MM) load is favorable for KT outcomes.
Claudia Lehmann, Sarah Pehnke, Antje Weimann, Anette Bachmann, Katalin Dittrich, Friederike Petzold, Daniel Fürst, Jonathan de Fallois, Ramona Landgraf, Reinhard Henschler, Tom H. Lindner, Jan Halbritter, Jan Halbritter, Ilias Doxiadis, Bernt Popp, Johannes Münch, Johannes Münch   +16 more
doaj   +1 more source