Results 1 to 10 of about 128,553 (116)

Anti-HLA antibodies bound to monocytes altered antibody-mediated platelet phagocytosis and led to mild thrombocytopenia [PDF]

Frontiers in Immunology
BackgroundIn fetal and neonatal alloimmune thrombocytopenia (FNAIT), maternal antibodies react with alloantigen expressed on fetal platelets, leading to their clearance via antibody-dependent phagocytosis.
Xiuzhang Xu, Nelli Baal, Martin Rick, Dawei Chen, Huaqin Liang, Xin Ye, Wenjie Xia, Hui Ren, Yaori Xu, Yongshui Fu, Yongshui Fu, Yongshui Fu, Gregor Bein, Sentot Santoso, Sentot Santoso   +14 more
doaj   +2 more sources

Prevalence of anti-HLA antibodies in COVID-19 convalescent plasma donors: an Indian experience [PDF]

Hematology, Transfusion and Cell Therapy
Background: COVID-19 convalescent plasma is one of the experimental therapies used widely in moderately sick COVID-19 patients. However, there are a few risks involved in plasma transfusion; notably, transfusion-related acute lung injury (TRALI) caused ...
Ram Mohan Jaiswal, Aseem Kumar Tiwari, Ashina Singla, Ashish Jain, Rajaat Vohra, Munish Kakkar, Prashanth Suravajhala   +6 more
doaj   +2 more sources

The fate of anti-HLA antibodies following liver transplantation [PDF]

Frontiers in Nephrology
IntroductionLiver transplant recipients may have pre-formed anti-HLA antibodies directed to mismatched HLA of the liver donor (donor specific antibodies, DSA) or not directed to the liver donor (non-donor specific, non-DSA). We observed the fate of these
Douglas J. Norman, Douglas J. Norman, C. Kristian Enestvedt, Willscott E. Naugler, Rouella Erhan, Carley A. Shaut   +5 more
doaj   +2 more sources

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets [PDF]

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +2 more sources

Prospective assessment of pre-existing and de novo anti-HLA IgE in kidney, liver, lung and heart transplantation

Frontiers in Immunology, 2023
IntroductionAntibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation. Anti-HLA donor-specific antibodies (DSA) of the IgG isotype are mainly responsible for ABMR.
Jasmin Mucha, Ara Cho, Ara Cho, Anna Marianne Weijler, Moritz Muckenhuber, Amun Georg Hofmann, Markus Wahrmann, Andreas Heinzel, Birgit Linhart, Pia Gattinger, Rudolf Valenta, Rudolf Valenta, Gabriela Berlakovich, Andreas Zuckermann, Peter Jaksch, Rainer Oberbauer, Thomas Wekerle   +16 more
doaj   +1 more source

Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation

Трансплантология (Москва), 2022
Introduction. Nowadays, there are few studies concerning assessment of the clinical significance of determining the level of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Aim.
I. V. Dmitriev, N. V. Borovkova, S. P. Shchelykalina, N. V. Doronina, N. S. Zhuravel, A. V. Pinchuk   +5 more
doaj   +1 more source

Assessment of Anti-Human Leukocyte Antigen (HLA)-Antibody-Dependent Humoral Response in Patients before and after Lung Transplantation

Medicina, 2022
Background and Objectives: Testing for anti-human leukocyte antigen (HLA) antibodies both before and after transplantation is of fundamental significance for the success of lung transplantation.
Anita Stanjek-Cichoracka, Marek Ochman, Elżbieta Chełmecka, Tomasz Hrapkowicz   +3 more
doaj   +1 more source

Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets

Haematologica, 2022
Approximately 20% of patients receiving multiple platelet transfusions develop platelet alloantibodies, which can be directed against human leukocyte antigens (HLA) and, to a lesser extent, against human platelet antigens (HPA).
Thijs L.J. van Osch, Janita J. Oosterhoff, Arthur E. H. Bentlage, Jan Nouta, Carolien A. M. Koeleman, Dionne M. Geerdes, Juk Yee Mok, Sebastiaan Heidt, Arend Mulder, Wim J. E. van Esch, Rick Kapur, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas, Manfred Wuhrer, Jan Voorberg, Gestur Vidarsson   +16 more
doaj   +1 more source

Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection

Transplantation Direct, 2021
Background. Antibody-mediated rejection (AMR) causes more than 50% of late kidney graft losses. In addition to anti-human leukocyte antigen (HLA) donor-specific antibodies, antibodies against non-HLA antigens are also linked to AMR.
Sergi Clotet-Freixas, PhD, Max Kotlyar, PhD, Caitriona M. McEvoy, MD, PhD, Chiara Pastrello, PhD, Sonia Rodríguez-Ramírez, MD, Sofia Farkona, PhD, Heloise Cardinal, MD, PhD, Mélanie Dieudé, PhD, Marie-Josée Hébert, MD, PhD, Yanhong Li, BSc, Olusegun Famure, MPH, MEd,, Peixuen Chen, HBSc, BScN, S. Joseph Kim, MD, PhD, Emilie Chan, MD, Igor Jurisica, PhD, Rohan John, MD, Andrzej Chruscinski, MD, PhD, Ana Konvalinka, MD, PhD   +17 more
doaj   +1 more source

Factors affecting the efficacy of platelet transfusion and specificity of HLA-Ⅰ antibodies in tumor patients

Zhongguo shuxue zazhi, 2023
Objective To analyze the factors affecting the efficacy of platelet transfusion and the specificity of HLA-Ⅰ antibodies in tumor patients. Methods Tumer patients applied for platelet transfusion from November 2019 to July 2021 in Sichuan Cancer Hospital ...
Juan SAI, Shanshan WAN, Li TIAN
doaj   +1 more source