Results 181 to 190 of about 90,955 (259)
TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3
Advanced Science, EarlyView.This study pinpoints TRIM56 as a viable candidate for promoting white adipose tissue browning and as a promising therapeutic target for addressing obesity and metabolic disorders. Functioning as an E3 ubiquitin ligase, TRIM56 facilitates the degradation of the TLE3 protein, thereby accelerating the thermogenic process and enhancing energy expenditure ...
Haojie Qin +5 more
wiley +1 more source
Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk [PDF]
, 2017 Sara Moukarzel +5 more
openalex +1 more source
Advanced Science, EarlyView.ADAM19 is identified as a novel target for senescent chondrocyte rejuvenation. Knockdown of ADAM19 results in the attenuation of cellular senescence and the formation of proliferative extracellular matrix‐synthesizing chondrocytes. senHMSN_si‐ADAM19 can target deliver therapeutic siRNA into senescent cells and rejuvenate hyaline cartilage in ...
Jiasheng Wang +6 more
wiley +1 more source
Advanced Science, EarlyView.This study specifically focuses on the role of oxytocin neurons in the hypothalamic paraventricular nucleus (PVN) in regulating obesity‐induced anxiety in mouse models. By combining chemogenetic, genetic, and pharmacological approaches, it is systematically demonstrated that oxytocin neurons in the PVN regulate anxiety induced by obesity through the ...
Baocheng Wan +7 more
wiley +1 more source
Wearable Standalone Sensing Systems for Smart Agriculture
Advanced Science, EarlyView.This review explores the development and application of wearable sensing systems for plant health monitoring. It examines different types of wearable plant sensors, including their design, working principles, and material choices, with an emphasis on their suitability for real‐world agricultural applications.
Dongpil Kim +5 more
wiley +1 more source
PIH22 - ECONOMIC IMPACT OF DONOR HUMAN MILK VERSUS FORMULA FOR VERY LOW BIRTH WEIGHT INFANTS IN THE NEONATAL INTENSIVE CARE UNIT [PDF]
, 2018 Tricia J. Johnson +3 more
openalex +1 more source
Advanced Science, EarlyView.This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier +4 more
wiley +1 more source
Advanced Science, EarlyView.Crizotinib induces excessive accumulation of squalene epoxidase (SQLE) by blocking its autophagic degradation. This accumulation disrupts cholesterol and sphingolipid metabolism, leading to hepatic steatosis or hepatocyte apoptosis, respectively. Autophagy activators, such as metformin, or SQLE enzymatic inhibitors, like terbinafine, possesses the ...
Hao Yan +14 more
wiley +1 more source
The availability of probiotics and donor human milk is associated with improved survival in very preterm infants [PDF]
, 2018 Janet Sharpe +3 more
openalex +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Advanced Science, EarlyView.MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi +9 more
wiley +1 more source