Results 201 to 210 of about 132,714 (327)

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer

Advanced Science, EarlyView.
Protein arginine methyltransferase 3 (PRMT3) induces the arginine methylation of Y‐box binding protein 1 (YBX1), which suppresses phase separation and is imperative for its nuclear translocation. Subsequently, lysine‐specific demethylase 4A demethylates YBX1 to unmask the R247 residue and promote its phase separation, which transcriptionally regulates ...
Yunxing Shi, Taixuan Wan, Shaoru Liu, Huashan Liu, Ziwei Zeng, Wenxin Li, Zhenxing Liang, Li Xiong, Shuanglin Luo, Yunfei Yuan, Liang Huang, Liang Kang   +11 more
wiley   +1 more source

Validation of a Real-Time PCR Assay for Fully Automated Detection of <i>Bacillus cereus</i> in Donor Human Milk. [PDF]

Microorganisms
Aran G, Pleguezuelos V, Blanco M, Garcia C, Jallow M, López M, Monge S, Casamitjana N, Alonso-Nogués E, Soria G.   +9 more
europepmc   +1 more source

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

Advanced Science, EarlyView.
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou, Yuqing Lv, Lin Li, Shukui Zhang, Jiaqi Liang, Chengchao Wu, Enyu Huang, Jianwei Jiao, Jingjing Zhang   +8 more
wiley   +1 more source

Impact of changing donor human milk feeding guideline for extremely preterm infants on the use of infant formula and cost of donor human milk purchase. [PDF]

J Perinatol
Zheng Y, Fowler J, Rector C, Tumin D, Herco M.   +4 more
europepmc   +1 more source

Donor human milk processing and its impact on infant digestion: A systematic scoping review of in vitro and in vivo studies. [PDF]

Adv Nutr, 2023
Pitino MA, Beggs MR, O'Connor DL, Doyen A, Pouliot Y, Sergius-Ronot M, Unger S.   +6 more
europepmc   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Enhanced versus standard fortification of pasteurized donor human milk for growth in very low birth weight infants: a randomized controlled trial. [PDF]

Front Nutr
Ong C, Wong AA, Wong ST, Zheng Y, Pang CPC, Jayagobi PA, Yeo JG, Yeo KT, Chua MC.   +8 more
europepmc   +1 more source

Experience using donor human milk: A single-center cohort study in Japan. [PDF]

Pediatr Int, 2022
Oikawa K, Nakano Y, Miyazawa T, Hasebe Y, Kuwabara H, Terada T, Sugishita Y, Ebata A, Takase M, Ochiai H, Kokaze A, Mizuno K.   +11 more
europepmc   +1 more source

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

Advanced Science, EarlyView.
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang, Huiying Sun, Ziheng Luo, Qinxin Zhang, Yarong Song, Jie Li, Xiaoyun Liu, Jie Wang   +7 more
wiley   +1 more source

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source