Results 51 to 60 of about 8,201,777 (292)

The Effects of Thermal Pasteurisation, Freeze-Drying, and Gamma-Irradiation on the Antibacterial Properties of Donor Human Milk

Foods, 2021
The most common pasteurisation method used by human milk banks is Holder pasteurisation. This involves thermal processing, which can denature important proteins and can potentially reduce the natural antimicrobial properties found in human milk.
Katherine Blackshaw, Jiadai Wu, Peter Valtchev, Edwin Lau, Richard B. Banati, Fariba Dehghani, Aaron Schindeler   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Recommendations for the Establishment and Operation of Human Milk Banks in Europe: A Consensus Statement From the European Milk Bank Association (EMBA)

Frontiers in Pediatrics, 2019
Objectives: To develop recommendations from the European Milk Bank Association (EMBA) for the establishment and operation of human milk banks (HMB) in Europe.Method: A working group comprising members of the EMBA was convened in 2015 to develop Europe ...
Gillian Weaver, Enrico Bertino, Corinna Gebauer, Anne Grovslien, Radmila Mileusnic-Milenovic, Sertac Arslanoglu, Debbie Barnett, Clair-Yves Boquien, Rachel Buffin, Antoni Gaya, Guido E. Moro, Aleksandra Wesolowska, Aleksandra Wesolowska, Jean-Charles Picaud, Jean-Charles Picaud   +14 more
doaj   +1 more source

High-Temperature Short-Time Preserves Human Milk's Bioactive Proteins and Their Function Better Than Pasteurization Techniques With Long Processing Times

Frontiers in Pediatrics, 2022
Donor human milk is generally processed by holder pasteurization (HoP) at 62. 5°C for 30 min. This temperature-time combination is sufficient for eliminating pathogens in donor milk, but also negatively affects several bioactive milk components.
Eva Kontopodi, Eva Kontopodi, Sjef Boeren, Bernd Stahl, Bernd Stahl, Johannes B. van Goudoever, Ruurd M. van Elburg, Kasper Hettinga   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies

Microorganisms, 2020
Correct establishment of the gut microbiome is compromised in premature babies, with Bifidobacterium being one of the most affected genera. Prematurity often entails the inability to successfully breastfeed, therefore requiring the implementation of ...
Silvia Arboleya, Silvia Saturio, Marta Suárez, Nuria Fernández, Leonardo Mancabelli, Clara G. de los Reyes-Gavilán, Marco Ventura, Gonzalo Solís, Miguel Gueimonde   +8 more
doaj   +1 more source

Comparison of the Effectiveness of Four Commercial DNA Extraction Kits on Fresh and Frozen Human Milk Samples

Methods and Protocols, 2022
For-profit donor human milk organizations have DNA-based proprietary methodology for testing incoming milk for adulteration with other species’ milk. However, there is currently no standardized methodology for extracting DNA from human milk.
Cassidy Butler, Amy Matsumoto, Casey Rutherford, Hope K. Lima   +3 more
doaj   +1 more source

A systematic review of contaminants in donor human milk. [PDF]

Matern Child Nutr
AbstractDonor human milk (DHM) from a milk bank is the recommended feeding method for preterm infants when the mother's own milk (MOM) is not available. Despite this recommendation, information on the possible contamination of donor human milk and its impact on infant health outcomes is poorly characterised.
Thayagabalu S, Cacho N, Sullivan S, Smulian J, Louis-Jacques A, Bourgeois M, Chen H, Weerasuriya W, Lemas DJ.   +8 more
europepmc   +6 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Considerations in Donor Human Milk Use in Premature Infants

, 2018
Considerations in Donor Human Milk Use in Premature ...
Yimin Chen (4053979)
core   +7 more sources