Results 61 to 70 of about 51,687 (296)

Effect of Pasteurisation Techniques on Phages in Human Milk

Proceedings, 2023
Bacteriophages (phages) are viruses that are the natural predators of bacteria and highly abundant in human milk and the infant gut microbiome. However, the effect of pasteurisation on human milk phages is unknown.
Lisa F. Stinson, Donna T. Geddes, Lucy L. Furfaro   +2 more
doaj   +1 more source

Donor human milk for Muslim infants in the UK

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2016
Donor human milk (DHM) is currently used in neonatal units (NNUs) for feeding preterm infants when own mother's milk is not available or insufficient. In 2014, the latest Cochrane review1 showed that in preterm and low birthweight infants, feeding with formula compared with DHM results in a higher risk of developing necrotising enterocolitis (NEC).
T C Williams, M Z Butt, S M Mohinuddin, A L Ogilvy-Stuart, M Clarke, G A Weaver, M S Shafi   +6 more
openaire   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The global status of human milk banking

Maternal and Child Nutrition
Human milk provides essential nutrition for infants and holds many health benefits for infants and mothers. When a mother's own milk is not available for her infant, the World Health Organization recommends feeding donor human milk (DHM) from a human ...
Kiersten Israel‐Ballard, Emily LaRose, Kimberly Mansen   +2 more
doaj   +1 more source

Donor human milk: actuality and perspectives [PDF]

Italian Journal of Pediatrics, 2015
Growing clinical evidences indicate the benefits of human milk (HM) for appropriate growth and development of a newborns: the particular composition make it a unique and inimitable nutrient [1]. Mother’s own milk is the first choice for all neonates including preterm infants, when it is unavailable or in short supply, donor milk (DM) is an important ...
Bertino, Enrico, Peila, Chiara, Coscia, Alessandra, Raia, Melissa, Rovelli, Ilaria, Rossi, Claudia, Cinatti, Natascia   +6 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Donor milk intake and infant growth in a South African neonatal unit: a cohort study

International Breastfeeding Journal, 2018
Background Implications of donor milk feedings on infant growth in resource limited settings remain uncertain. This knowledge gap includes the impact of donor milk availability on infant intake of mother’s own milk. Therefore, this investigation aimed to
Hayley Sparks, Lucy Linley, Jennifer L. Beaumont, Daniel T. Robinson   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source