Results 111 to 120 of about 8,564,356 (290)

Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant [PDF]

, 2018
The presence of donor-specific anti-HLA antibodies (DSAs) is associated with increased risk of graft failure after kidney transplant. We hypothesized that DSAs against HLA class I, class II, or both classes indicate a different risk for graft loss ...
Drop, A. C. A. D., E.M. van Duijnhoven, Lardy, N.M., Nurmohamed, SA, van der Pant, K A, Sanders, J. S.F., Drop, A, van Ittersum, FJ, Seelen, M. A. J., van der Weerd, N C, J.S.F. Sanders, van der Weerd, NC, Roelen, D L, Plaisier, L., Bots, M. L., Boog, P.J.M. van der, Tilanus, M. G.J., J.W. de Fijter, van der Weerd, N. C., Hilbrands, L B, Bots, M L, Hepkema, B.G., Claas, F H, Betjes, M. G.H., Christiaans, M. H. L., Gelens, M, van Zuilen, A. D., Hilbrands, L.B., Wisse, B.W., Lambeck, A. J.A., Voorter, C. E., Hoitsma, A., A.D. van Zuilen, Heidt, S, Spierings, E., Tilanus, M. G. J., M.H.L. Christiaans, Nurmohamed, S.A., Verhaar, M. C., A. van der Meer, S. Heidt, Joosten, I., Hepkema, B G, Lambeck, A J, Seelen, M.A.J., Hepkema, BG, Allebes, W. A., Hack, C. E., L.B. Hilbrands, van der Boog, P J M, Baas, M.C., N.C. van der Weerd, Nurmohamed, S A, Sanders, J S F; id_orcid, Lardy, NM, Verhaar, M C, S.A. Nurmohamed, van Zuilen, A D, Heidt, S; id_orcid, Meer, A. van der, van der Boog, P. J.M., Otten, HG, Seelen, M A J, Allebes, W.A., Bungener, L.B., Verhaar, M.C., Wieten, L, Verhaar, MC, M.G.J. Tilanus, N.M. Lardy, Ten Berge, I J M, H.G. Otten, F.J. Bemelman, Hack, C E, Bungener, L. B., van der Meer, A, E.G. Kamburova, M. Gelens, Swelsen, W., van Reekum, F. E., M.L. Bots, Lambeck, A.J.A., F.E. van Reekum, Zuilen, A.D. van, Kamburova, E. G., van Ittersum, F. J., B.W. Wisse, Otten, H. G., Seelen, M. A.J., Baas, M C, Christiaans, MHL, Allebes, WA, Hack, CE, Roozendaal, C, Hepkema, B. G., Kamburova, E.G., I. Joosten, Weerd, N.C. van der, K.A. van der Pant, M.C. Verhaar, Otten, H.G., Sanders, J.S.F., ten Berge, IJM, van der Boog, P. J. M., L.B. Bungener, M.A.J. Seelen, Tilanus, MGJ, Lambeck, AJA, Bemelman, F J, van Ittersum, F J, Drop, A.C.A.D., Nurmohamed, S. A., Kamburova, E G, Bemelman, FJ, C.E. Hack, Roelen, D. L., Duijnhoven, E.M. van, Bemelman, F. J., Fijter, J.W. de, Betjes, M. G. H., Roozendaal, C., Lardy, N. M., Plaisier, L, M.G.H. Betjes, van Reekum, F E, W. Swelsen, Otten, H G, Baas, M. C., Tilanus, M G J, de Fijter, J W, van der Meer, A., ten Berge, I. J.M., Pant, K.A. van der, M.C. Baas, de Fijter, J. W., Sanders, J S F, Roelen, DL, P.J.M. van der Boog, Sanders, J. S. F., Bungener, L B, A. Hoitsma, L. Plaisier, Berge, I.J.M. ten, Allebes, W A, A.J.A. Lambeck, Claas, FH, Hilbrands, LB, D.L. Roelen, Christiaans, M H L, Wisse, B W, C. Roozendaal, ten Berge, I. J. M., W.A. Allebes, Bots, ML, van Duijnhoven, E. M., Sanders, JSF, Spierings, E, Betjes, M G H, F.H. Claas, Heidt, S., Tilanus, M.G.J., Bungener, LB, Lardy, N M, Meer, A, B.G. Hepkema, Gelens, M., Christiaans, M.H.L., Seelen, MAJ, Voorter, C E, Wisse, B. W., E. Spierings, Lambeck, A. J. A., van Duijnhoven, E M, Betjes, M.G.H., Hilbrands, L. B., Drop, A. C.A.D., Bemelman, F.J., Christiaans, M. H.L., I.J.M. ten Berge, van Zuilen, AD, Joosten, I, Roelen, D.L., Wieten, L., Bots, M.L., Voorter, C.E., Hoitsma, A, Hack, C.E., Claas, F.H., A.C.A.D. Drop, Voorter, CE, de Fijter, JW, Swelsen, W, Drop, A C A D, Reekum, F.E. van, F.J. van Ittersum, Ittersum, F.J. van, L. Wieten, van der Pant, K. A., C.E. Voorter, Claas, F. H., MS Nefrologie, Regenerative Medicine and Stem Cells, MS Mondziekten/Kaakchirurgie, Circulatory Health, CTI Otten, Nefro Vasculaire Geneeskunde, Cardiovasculaire Epi Team 5, CDL Celdiagnostiek, Infection & Immunity, JC onderzoeksprogramma Cardiovascular Health, CTI   +210 more
core   +1 more source

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection

Journal of Immunology Research, 2017
Consistent with Dr. Paul Terasaki’s “humoral theory of rejection” numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Carrie L. Butler, Nicole M. Valenzuela, Kimberly A. Thomas, Elaine F. Reed   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Donor-specific antibodies require preactivated immune system to harm renal transplant

EBioMedicine, 2016
Background: It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from
Caner Süsal, Bernd Döhler, Andrea Ruhenstroth, Christian Morath, Antonij Slavcev, Thomas Fehr, Eric Wagner, Bernd Krüger, Margaret Rees, Sanja Balen, Stela Živčić-Ćosić, Douglas J. Norman, Dirk Kuypers, Marie-Paule Emonds, Przemyslaw Pisarski, Claudia Bösmüller, Rolf Weimer, Joannis Mytilineos, Sabine Scherer, Thuong H. Tran, Petra Gombos, Peter Schemmer, Martin Zeier, Gerhard Opelz   +23 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Strenght/Specificity of de novo HLA donor-specific antibodies in Kidney Transplantation

, 2009
Aim Post-transplant development of donor-specific antibodies (DSA) had been associated with adverse kidney transplant outcome. Methods In 466 kidney transplanted patients we analyzed the clinical impact of de novo HLA-DSA by Luminex-Single Antigen ...
Elvira Poggi, Antonina Piazza, Domenico Adorno, Giuseppina Ozzella   +3 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Outcomes of belatacept-based quadruple immunosuppression therapy in kidney transplant recipients with persistent alloimmune response: a single-center observational study

Frontiers in Immunology
We conducted a retrospective review of adult kidney transplant recipients (KTRs) who received belatacept in addition to calcineurin inhibitors, antimetabolites, and corticosteroids for recurrent or refractory rejection or for persistent donor-specific ...
Basheer Ahamad Kummangal, Ali Olyaei, Angelo de Mattos, Shehzad Rehman, Justin Smith, Megan Stack, Zoha Ahmad, Jay Pandav   +7 more
doaj   +1 more source