Results 91 to 100 of about 8,564,356 (290)

In Vivo Emergence of HIV-1 Highly Sensitive to Neutralizing Antibodies [PDF]

, 2011
Background: The rapid and continual viral escape from neutralizing antibodies is well documented in HIV-1 infection. Here we report in vivo emergence of viruses with heightened sensitivity to neutralizing antibodies, sometimes paralleling the development
O'Farrell Stephen, Pellegrino, P, Williams Ian, Williams, IG, Kelly M Cheney, Áine McKnight, Anna Forsman, Cheney, Kelly M, McKnight, Áine, Cheney Kelly M., Hué, Stéphane, Forsman Anna, Marlén M I Aasa-Chapman, McKnight, A, Marlén M. I. Aasa-Chapman, Ian Williams, Aasa-Chapman, Marlén MI, Cheney, KM, O'Farrell, S, Stéphane Hué, Kelly M. Cheney, Pellegrino, Pierre, Stephen O'Farrell, Forsman, A, O'Farrell, Stephen, Pierre Pellegrino, Williams, Ian, Forsman, Anna, Aasa-Chapman Marlén M. I., Aasa-Chapman, MMI, Hué Stéphane, McKnight Áine, Pellegrino Pierre, Williams, I, Hue, S, Aasa-Chapman, MM   +35 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Kolb, Hans-Jochem, Roskrow, Marie, Guenther, Wolfgang, Schmid, Christoph, Ledderose, Georg, Weber, Martin, Chen, Xiao, Schleuning, Michael, Woiciechowski, Anja   +8 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

HLA class I donor-specific triplet antibodies detected after renal transplantation

, 2004
The purpose of this study was to investigate whether IgG, non-donor-specific anti-HLA class I antibodies (HLAabI) detected after renal transplantation recognize immunogenic amino acid triplets expressed on the foreign graft.
Iniotaki-Theodoraki, A, Doxiadis, IIN, Patargias, T, Stavropoulos-Giokas, C, Kyriakides, GK, Varnavidou-Nicolaidou, A   +5 more
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation [PDF]

In kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant.
Heidt, Sebastiaan, van der Pant, Karlijn A. M. I., Sanders, Jan Stephan, Gelens, Mariëlle A.C.J., van der Meer, Arnold, Lambeck, Annechien J. A., Wieten, Lotte, Seelen, Marc A.J., Otten, Henny G., Sanders, Jan Stephan; id_orcid, Plaisier, Loes, Roelen, Dave L., van Ittersum, Frans J., van Zuilen, Arjan D., Wisse, Bram W., de Fijter, Johan W., van der Boog, Paul J.M., ten Berge, Ineke J. M., Lardy, Neubury M., Kamburova, Elena G., Gruijters, Maartje L., Heidt, Sebastiaan; id_orcid, Reteig, Leon, Tilanus, Marcel G.J., Bemelman, Frederike J., Verhaar, Marianne C., Gelens, Marielle A. C. J., Swelsen, Wendy, Christiaans, Maarten H. L., van Reekum, Franka E., Melchers, Rowena C. A., Hilbrands, Luuk B., Kardol-Hoefnagel, Tineke, Betjes, Michiel G. H., Naesens, Maarten, Melchers, Rowena C.A., van der Pant, Karlijn A.M.I., van Duijnhoven, Elly M., Hack, Cornelis E., Baas, Marije C., Joosten, Irma, Drop, Adriaan C.A.D., Christiaans, Maarten H.L., Senev, Aleksandar, Claas, Frans H., Betjes, Michiel G.H., Bots, Michiel L., Hoitsma, Andries, Drop, Adriaan C. A. D., van der Weerd, Neelke C., Seelen, Marc A. J., Allebes, Wil A., van der Boog, Paul J. M., Senejohnny, Danial Mohammadi, Voorter, Christina E., Hepkema, Bouke G., ten Berge, Ineke J.M., Spierings, Eric, Lambeck, Annechien J.A., Tilanus, Marcel G. J., Nurmohamed, Shaikh A., Bungener, Laura B., Roozendaal, Caroline, Otten, H.G., Kardol-Hoefnagel, T., Senev, A., Lardy, N.M., Drop, A.C.A.D., Duijnhoven, E.M. van, Fijter, J.W. de, Roozendaal, C., Plaisier, L., Boog, P.J.M. van der, Melchers, R.C.A., Hepkema, B.G., Hilbrands, L.B., Gelens, M.A.C.J., Berge, I.J.M. ten, Naesens, M., Wisse, B.W., Hoitsma, A., Spierings, E., Nurmohamed, S.A., Joosten, I., Seelen, M.A.J., van der Pant, Karlijn A.MI., Baas, M.C., Tilanus, M.G.J., Heidt, S., Meer, A. van der, Christiaans, M.H.L., Allebes, W.A., Bungener, L.B., Verhaar, M.C., Reteig, L., Gruijters, M.L., Betjes, M.G.H., Bemelman, F.J., Senejohnny, D.M., Roelen, D.L., Wieten, L., Swelsen, W., Bots, M.L., Lambeck, A.J.A., Voorter, C.E., Hack, C.E., Zuilen, A.D. van, Claas, F.H., Drop, Adriaan C.AD., Pant, K.A.M.I. van der, Reekum, F.E. van, Ittersum, F.J. van, Kamburova, E.G., Gelens, Marielle A.CJ., Weerd, N.C. van der, Sanders, J.S.   +115 more
core   +5 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

A Symposium on Donor‐Specific Antibodies after Transplantation Introduction [PDF]

Pediatric Transplantation, 2011
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/106818/1/j.1399-3046.2011.01521.x ...
openaire   +3 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source