Results 281 to 290 of about 506,450 (362)

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source

New nanomanufacturing strategy through bioinspired design, for promising treatment of Parkinson's disease. [PDF]

Sci Rep
Razzak AA, Al-Garawi ZS, Haider AJ, Hassan FAANB.   +3 more
europepmc   +1 more source

Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury

Animal Models and Experimental Medicine, EarlyView.
Exercise and astrocyte reprogramming synergize to enhance motor function and reduce glial scarring after spinal cord injury, with combined therapies surpassing individual effects. Abstract Background The inability of damaged neurons to regenerate and of axons to establish new functional connections leads to permanent functional deficits after spinal ...
Zuliyaer Talifu, Xin Xu, Huayong Du, Zehui Li, Xiaoxin Wang, Chunjia Zhang, Yunzhu Pan, Han Ke, Wubo Liu, Feng Gao, Degang Yang, Yingli Jing, Yan Yu, Liangjie Du, Jianjun Li   +14 more
wiley   +1 more source

Timing of hydrocortisone therapy in neonates with shock: a systematic review, meta-analysis, and clinical practice guideline. [PDF]

Front Pediatr
Ramaswamy VV, Kumar G, Pullattayil S AK, Aradhya AS, Suryawanshi P, Sahni M, Khurana S, Saini SS, K R, Dhir SK, Chawla D, Kumar P, More K.   +12 more
europepmc   +1 more source

Comparison of the effects of dobutamine with dopamine and isoproterenol on inotropism and chronotropism in the mammalian heart

, 1979
Issei Imanaga, TAKAKO KANEDA, N Miyakawa
openalex   +2 more sources

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Neurotransmitters' white matter mapping unveils the neurochemical fingerprints of stroke. [PDF]

Nat Commun
Alves PN, Nozais V, Hansen JY, Corbetta M, Nachev P, Martins IP, Thiebaut de Schotten M.   +6 more
europepmc   +1 more source

Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease

Animal Models and Experimental Medicine, EarlyView.
Sydenham's chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF), triggered by a group A streptococcal (GAS) infection. Anti‐GAS antibodies cross‐reacting with tissue proteins are implicated in the development of neurological changes. In this study, using an animal model, we demonstrate that a compromised blood–brain
Rukshan Ahamed Mohamed Rafeek, Riya Thapa, Samarjeet Saluja, Bipandeep Banga, David McMillan, Kadaba Sri Sriprakash, Nicholas M. Andronicos, Adam Hamlin, Natkunam Ketheesan   +8 more
wiley   +1 more source

Stimulation of tubero‐infundibular dopamine neurones and gonadotrophin secretion

, 1971
Paul J. Keller, W. Lichtensteiger
openalex   +2 more sources

Modeling Sporadic Progressive Supranuclear Palsy in 3D Midbrain Organoids: Recapitulating Disease Features for In Vitro Diagnosis and Drug Discovery

Annals of Neurology, EarlyView.
Objective Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP is challenging due to the lack of disease models reproducing its key pathological features.
Elvira Immacolata Parrotta, Valeria Lucchino, Clara Zannino, Desirèe Valente, Stefania Scalise, Davide Bressan, Giorgia Lucia Benedetto, Maria Roberta Iazzetta, Mariagrazia Talarico, Monica Gagliardi, Francesco Conforti, Silvia Di Agostino, Alessandro Fiorenzano, Aldo Quattrone, Giovanni Cuda, Andrea Quattrone   +15 more
wiley   +1 more source