Results 81 to 90 of about 786,774 (402)
Dopamine: Differentially Private Federated Learning on Medical Data [PDF]
arXiv, 2021 While rich medical datasets are hosted in hospitals distributed across the world, concerns on patients' privacy is a barrier against using such data to train deep neural networks (DNNs) for medical diagnostics. We propose Dopamine, a system to train DNNs on distributed datasets, which employs federated learning (FL) with differentially-private ...
arxiv
On the Origin of Tremor in Parkinson's Disease [PDF]
(2012) PLoS ONE 7(7): e41598, 2012 The exact origin of tremor in Parkinson's disease remains unknown. We explain why the existing data converge on the basal ganglia-thalamo-cortical loop as a tremor generator and consider a conductance-based model of subthalamo-pallidal circuits embedded into a simplified representation of the basal ganglia-thalamo-cortical circuit to investigate the ...
arxiv +1 more source
Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit [PDF]
, 2009 The striatum, the principal input structure of the basal ganglia, is crucial to both motor control and learning. It receives convergent input from all over the neocortex, hippocampal formation, amygdala and thalamus, and is the primary recipient of ...
Alexander +92 more
core +1 more source
Folia Endocrinologica Japonica, 1993 Dopamine has been well recognized to be a precursor of norepinephrine, exhibiting cardiovascular effects through alpha-adrenoceptor stimulation by norepinephrine production and release in sympathetic nerve endings. It also has the specific and unique effects of natriuresis and vasodilation.
Soitsu Fukuchi, Shuichi Sigetomi
openaire +4 more sources
The Mechanism and Pathways of Dopamine and Dopamine Agonists in Prolactinomas [PDF]
Frontiers in Endocrinology, 2019 Dopamine agonists such as bromocriptine and cabergoline are the predominant treatment drugs for prolactinoma by inhibiting prolactin secretion and shrinking tumor size. However, the pathways of either dopamine or its agonists that lead to the death of cells are incompletely understood and some are even conflicting conclusions.
Chao Tang +6 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.This study reports a novel strategy for preparing a biocompatible adhesive hydrogel crosslinked with a muscle tissue‐derived extracellular matrix (MEM) for in situ muscle regeneration. As a natural crosslinker, MEM not only mediates combinatorial polymer networks but also stimulates satellite cells to induce a cell‐free therapeutic solution.
Eun Je Jeon +6 more
wiley +1 more source
Neurobiology of Disease, 2015 The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that accumulation of dopamine in the cytosol
S.T. Masoud +16 more
doaj
Frontiers in Synaptic Neuroscience, 2018 This perspective article provides observations supporting the view that nigro-striatal dopamine neurons and meso-limbic dopamine neurons mainly communicate through short distance volume transmission in the um range with dopamine diffusing into ...
Dasiel O. Borroto-Escuela +17 more
doaj +1 more source
eLife, 2022 Repeated exposure to drugs of abuse results in an upregulation of cAMP signaling in the mesolimbic dopamine system, a molecular adaptation thought to be critically involved in the development of drug dependence.
Xiaojie Liu +10 more
doaj +1 more source
STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE
Nature, 2018 Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion.
Sheng Wang +5 more
semanticscholar +1 more source