Results 101 to 110 of about 1,754,831 (304)
Frontiers in Cellular Neuroscience, 2013 Schizophrenia is a heterogeneous group of disorders with unknown aetiology. Although abnormalities in multiple neurotransmitter systems have been linked to schizophrenia, alterations in dopamine neurotransmission remain central to the treatment of this ...
James P. Kesby +5 more
doaj +1 more source
PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
Advanced Science, EarlyView.PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source
Scientific ReportsThe characteristics of dopamine self-polymerization were used to cover the nano-titanium dioxide (TiO2) surface and produce nano-titanium dioxide-polydopamine (TiO2-PDA).
Dongdong Hao +3 more
doaj +1 more source
Comparison of Sympathomimetics in the Correction of Arterial Hypotension during Combined Anesthesia
Общая реаниматология, 2012 Objective: to make a comparative assessment of hemodynamic parameters when correcting combined anesthesia-induced arterial hypotension with dopamine, adrenaline, mesatone, or noradrenaline. Subjects and methods.
D. B. Borisov +4 more
doaj +1 more source
Advanced Science, EarlyView.An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai +10 more
wiley +1 more source
Neuromelanin-sensitive MRI as a proxy-measure of dopamine function in neuropsychiatric illness.
, 2016 Neuromelanin-sensitive MRI as a proxy-measure of dopamine function in neuropsychiatric ...
Kang U +10 more
core
Advanced Science, EarlyView.An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan +7 more
wiley +1 more source
Carborane Analog of Dopamine D3 Receptor Antagonist Eticlopride
, 2016 Dopamine, a small neurotransmitter released by the brain, plays a major role in the body's reward and motivation systems. Dopamine interacts with a class of G-Protein coupled receptors-- D1R through D5R-- to propagate or mitigate the dopamine signaling ...
Ashbrook, Caleb
core
Parkinson's disease (PD) is characterized by a set of motor symptoms that depend on nigrostriatal dopaminergic degeneration and respond well to pharmacological dopamine replacement using L-DOPA.
Rosqvist, Kristina +6 more
core +1 more source
Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation
Advanced Science, EarlyView.Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu +10 more
wiley +1 more source