Results 1 to 10 of about 14,827 (208)
Clinical and Translational Science, 2021 Apomorphine is an on‐demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD). A joint parent‐metabolite population pharmacokinetic (PK) model characterized apomorphine and apomorphine‐sulfate following administration of apomorphine ...
Felix Agbo +6 more
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Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease [PDF]
Asian Journal of Pharmaceutical Sciences, 2018 Parkinson's disease (PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss.
Nrupa Borkar, Huiling Mu, René Holm
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MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro [PDF]
PeerJ, 2013 The MCH and dopamine receptor systems have been shown to modulate a number of behaviors related to reward processing, addiction, and neuropsychiatric conditions such as schizophrenia and depression. In addition, MCH and dopamine receptors can interact in
F Woodward Hopf +3 more
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Clinical Parkinsonism & Related Disorders, 2023 Introduction: Pretreatment with the antiemetic trimethobenzamide has been recommended practice in the United States (US) to address the risk of nausea and vomiting during initiation of apomorphine treatment.
Stuart H. Isaacson +3 more
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Subcutaneous apomorphine in advanced Parkinson’s disease and its use in Indian population
Annals of Movement Disorders, 2020 Although subcutaneously administered apomorphine is widely used as an effective adjunct therapy for Parkinson’s disease (PD), it was approved for use in India only in 2019. This review summarizes the history, pharmacology, clinical spectrum, indications,
Vinod Metta +7 more
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Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish
Frontiers in Neuroscience, 2022 Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine kinase family, known to be involved in cell proliferation, differentiation and activation of transcription factors.
Adele Leggieri +9 more
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Arquivos de Neuro-Psiquiatria, 2021 Background: Impulsive compulsive behaviors (ICBs) can affect a significant number of Parkinson’s disease (PD) patients. Objective: We have studied brain samples from a brain bank of PD patients who received apomorphine via continuous infusion in life to
Pedro Barbosa +3 more
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Pakistan Journal of Pharmaceutical Sciences, 2020 Drug abuse and impaired adaptation to stress are inter-related. Drug abuse is more potentiated upon exposure to stress and an impairment to cope with stress may lead to depression.
Huma Ikram +4 more
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