Results 41 to 50 of about 13,147 (207)

Intravenous apomorphine therapy in Parkinson's disease - Clinical and pharmacokinetic observations [PDF]

, 2021
Six patients with Parkinson's disease and refractory motor fluctuations, with severe subcutaneous (s,c,) nodule formation as a result of long-term s,c, apomorphine infusions, were switched to intravenous (i,v,) therapy via a long-term in-dwelling venous ...
Hanagasi, Haşmet Ayhan, Turner, K, Ratnaraj, N, Lees, AJ, Patsalos, PN, Manson, AJ, Carey, P   +6 more
core   +1 more source

Progress Toward the Synthesis of Apomorphine: Chiral Auxiliary Mediated Interception of an Intramolecularly Formed N-Acyl Iminium Ion [PDF]

, 2004
Glaucine, which contains an aporphine skeleton, has been previously synthesized utilizing an intermolecular approach to form an iminium ion for the Pictet-Spengler reaction.
Nuckols, Michel Christian
core  

Continuous Intrajejunal Levodopa–Carbidopa Infusion in Parkinson's Disease Associated with 22q11.2 Deletion Syndrome: A Case Series

Movement Disorders Clinical Practice, EarlyView.
Abstract Background 22q11.2 deletion syndrome (22q11DS) is a multisystem genetic disorder associated with a significantly increased risk of early‐onset Parkinson's disease (EOPD). Management is challenging because psychiatric and cognitive comorbidities often limit advanced therapies such as deep brain stimulation (DBS). Cases We report 2 patients with
Valle Victor Andrés, Jardel Amory, Hopes Lucie, Clément Guillemette, Lambert Laetitia, Becker Aurélie, Dexheimer Mylène, Bonnet Céline, Frismand Solène, Renaud Mathilde, Puisieux Salomé   +10 more
wiley   +1 more source

Apomorphine Suppresses the Progression of Steatohepatitis by Inhibiting Ferroptosis

Antioxidants
The role of ferroptosis in steatohepatitis development is largely unknown. We investigated (1) whether hepatocyte ferroptosis occurs in a gene-modified steatohepatitis model without modifying dietary components, (2) whether ferroptosis occurs at an early
Hiroshi Maeda, Kouichi Miura, Kenichi Aizawa, Oyunjargal Bat-Erdene, Miho Sashikawa-Kimura, Eri Noguchi, Masako Watanabe, Naoya Yamada, Hitoshi Osaka, Naoki Morimoto, Hironori Yamamoto   +10 more
doaj   +1 more source

Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks [PDF]

, 2004
PURPOSE: The inhibitory effect of apomorphine on form-deprivation myopia implies a role for dopaminergic pathways in eye growth; however, the effect of apomorphine on lens-induced changes has not been studied. Our study filled this deficiency.
Wildsoet, Christine F., Schmid, Katrina L.   +1 more
core  

High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor

Molecules, 2020
The global SARS-CoV-2 pandemic started late 2019 and currently continues unabated. The lag-time for developing vaccines means it is of paramount importance to be able to quickly develop and repurpose therapeutic drugs.
Alistair S. Brown, David F. Ackerley, Mark J. Calcott   +2 more
doaj   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Integrating technology into a successful apomorphine delivery program in Thailand: a 10-year journey of achievements with a five-motto concept

Frontiers in Neurology
IntroductionApomorphine, a potent dopamine agonist, is a therapeutic option for patients with Parkinson’s disease and motor fluctuations. However, the adoption of and adherence to this therapy have been limited by the need for complex delivery devices ...
Onanong Phokaewvarangkul, Nithinan Kantachadvanich, Vijittra Buranasrikul, Kanyawat Sanyawut, Saisamorn Phumphid, Chanawat Anan, Roongroj Bhidayasiri, Roongroj Bhidayasiri   +7 more
doaj   +1 more source

Neuroendocrine Assessment of Dopaminergic Function during Antidepressant Treatment in Major Depressed Patients

Brain Sciences, 2021
The effects of antidepressants on dopamine (DA) receptor sensitivity in the mesolimbic–hypothalamic system have yielded contradictory results. The postsynaptic DA receptor function was evaluated by the cortisol response to apomorphine (APO; 0.75 mg SC ...
Fabrice Duval, Marie-Claude Mokrani, Alexis Erb, Felix Gonzalez Lopera, Vlad Danila, Mihaela Tomsa   +5 more
doaj   +1 more source

Cocaine strongly reduces prepulse inhibition in apomorphine-susceptible rats, but not in apomorphine-unsusceptible rats: regulation by dopamine D2 receptors. [PDF]

, 2006
Contains fulltext : 50736.pdf (Publisher’s version ) (Closed access)Dopaminergic agonists, such as apomorphine and amphetamine, have been shown to drastically reduce prepulse inhibition of the acoustic startle reflex. The effects of the
Elst, M.C.J. van der, Cools, A.R., Ellenbroek, A.A.   +2 more
core   +1 more source