Results 51 to 60 of about 21,736 (211)
Frontiers in NeurologyIntroductionApomorphine, a potent dopamine agonist, is a therapeutic option for patients with Parkinson’s disease and motor fluctuations. However, the adoption of and adherence to this therapy have been limited by the need for complex delivery devices ...
Onanong Phokaewvarangkul +7 more
doaj +1 more source
High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor
Molecules, 2020 The global SARS-CoV-2 pandemic started late 2019 and currently continues unabated. The lag-time for developing vaccines means it is of paramount importance to be able to quickly develop and repurpose therapeutic drugs.
Alistair S. Brown +2 more
doaj +1 more source
Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo [PDF]
, 2014 A new working hypothesis of Parkinson's disease (PD) proposes to focus on the central role of entropy increase in the basal ganglia (BG) in movement disorders. The conditions necessary for entropy increase in vivo are, however, still not fully described.
Andres, Daniela Sabrina +3 more
core +3 more sources
Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review
Movement Disorders Clinical Practice, EarlyView.Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes +6 more
wiley +1 more source
Medication Knowledge of Patients with Parkinson's Disease: Strengths and Gaps
Movement Disorders Clinical Practice, EarlyView.Abstract Background Effective drug treatment of motor and non‐motor symptoms in Parkinson's disease (PD) often requires the administration of several anti‐Parkinson drugs in complex treatment regimens. The successful autonomous application of drugs places high demands on therapy adherence, which in turn relies on sufficient medication knowledge ...
Stephan Greten +9 more
wiley +1 more source
Apomorphine Suppresses the Progression of Steatohepatitis by Inhibiting Ferroptosis
AntioxidantsThe role of ferroptosis in steatohepatitis development is largely unknown. We investigated (1) whether hepatocyte ferroptosis occurs in a gene-modified steatohepatitis model without modifying dietary components, (2) whether ferroptosis occurs at an early
Hiroshi Maeda +10 more
doaj +1 more source
Dopaminergic Neuronal Loss and Dopamine-Dependent Locomotor Defects in Fbxo7-Deficient Zebrafish [PDF]
, 2012 Recessive mutations in the F-box only protein 7 gene (FBXO7) cause PARK15, a Mendelian form of early-onset, levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons.
Bonifati, V. (Vincenzo) +5 more
core +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Microscopic colitis (MC) typically presents with chronic, non‐bloody watery diarrhea. Diagnosis requires endoscopy with colonic mucosal biopsies. The etiology is multifactorial, with several medications implicated, although only a few cases have been attributed to oral levodopa/dopa‐decarboxylase inhibitor (LDDCI) therapy.
Romana Hintner +10 more
wiley +1 more source
Apomorphine effects on the hippocampus
Neural Regeneration Research, 2018 Apomorphine is a non-specific dopamine receptor agonist that has been used in the treatment of some diseases and mental disorders. Its use has particularly well documented in Parkinson's disease (PD).
Luis Enrique Arroyo-Garcia +2 more
doaj +1 more source
The site of emetic action of veratrum derivatives. [PDF]
, 1951 Thesis (M.A.)--Boston ...
Swiss, Edward D
core +1 more source