Results 31 to 40 of about 21,736 (211)

Erectile dysfunction - an update of current practice and future strategies [PDF]

, 2013
Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse.1 Up to 150 million men worldwide suffer from ED and this figure is likely to double by the year 2025.2 A number
Kalsi, J, Muneer, A
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Memantine increases NMDA receptor level in the prefrontal cortex but fails to reverse apomorphine-induced conditioned place preference in rats [PDF]

, 2018
Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective.
Baxter BL, Gluckman MI, Stein L, et al., Bisaga A, Comer SD, Ward AS, et al., Campbell JC, Jeyamohan SB, De LCP, et al., Chen G, Greengard P, Yan Z, Chen SL, Tao PL, Chu CH, et al., Di CP, Everitt BJ, Dos SER, Daval J, Koziel V, et al., El-Bachá RS, Netter P, Minn A, Haleem DJ, Ikram H, Haleem MA, Kelley AE, Kemp JA, Mckernan RM, Overton PG, Clark D, Papp M, Parsons CG, Popik P, Layer RT, Skolnick P, Popik P, Skolnick P, Popik P, Wrobel M, Bisaga A, Sam E, Verbeke N, Sattler R, Tymianski M, Singh N, Pillay V, Choonara YE, Spyraki C, Fibiger HC, Phillips AG, Téllez C, Bustamante ML, Toro P, et al., Uys JD, Lalumiere RT, Van dKD, Swerdlow NR, Koob GF, Volkow ND, Fowler JS, Wang GJ, et al., Wu PH, Mihic SJ, Liu JF, et al., Zweifel LS, Argilli E, Bonci A, et al.   +26 more
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Inhaled Apomorphine in Patients with ‘on-off’ Fluctuations: A Randomized, Double-blind, Placebo-controlled, Clinic and Home Based, Parallel-group Study

Journal of Parkinson’s Disease, 2013
Background: In later stages of Parkinson's disease, treatment of ‘off’ periods with subcutaneous apomorphine is helpful but requires injection; inhaled apomorphine would be potentially more convenient. Objectives: To identify optimal efficacy, safety and
Katherine A. Grosset, Naveed Malek, Frazer Morgan, Donald G. Grosset   +3 more
doaj   +1 more source

Catecholamine-Based Treatment in AD Patients: Expectations and Delusions. [PDF]

, 2015
In Alzheimer disease, the gap between excellence of diagnostics and efficacy of therapy is wide. Despite sophisticated imaging and biochemical markers, the efficacy of available therapeutic options is limited.
Alessandro eStefani, Alessandro eStefani, Atticus H Hainsworth, Claudio eLiguori, Enrica eOlivola, Giacoma eAngileri, Mariangela ePierantozzi, Salvatore eGalati, Valentina eSaviozzi, Vincenza eD’Angelo   +9 more
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Myopes have significantly higher serum melatonin concentrations than non-myopes [PDF]

, 2017
Purpose Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation.
Ackermann, Atkinson, Ayaki, Baba, Barnard, Beck-Friis, Benavente-Pérez, Benloucif, Berg, Bertolet, Besharse, Breslin, Brown, Cahill, Chang, Chiba, Chua, Delgado, Dong, Eisenberg, Fan, Freedman, Guo, Hammond, He, Hua, Huang, Huang, Hughes, Iuvone, Jee, Kivelä, Lanyon, Logan, Lu, Mallen, Mao, Martin, McCullough, Megaw, Megaw, Nickla, Nickla, Ohngemach, Panda, Pendrak, Rada, Rao, Riefahn, Rohrer, Rose, Rudnicka, Sankaridurg, Skene, Stone, Stone, Stormann, Tosini, Trier, Verkicharla, Wahl, Wallman, Wang, Weiss, Wiechmann, Wiechmann, Wilson, Witkovsky, Wu, Xu, Zhang   +70 more
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Turmeric active substance, curcumin, enhanced apomorphine-induced yawning in rats [PDF]

Avicenna Journal of Phytomedicine, 2013
Objective: Curcumin is a major constituent of turmeric and influences many functions of the brain. In the present study, we investigated the effect of curcumin on yawning induced by apomorphine in rats.
Esmaeal Tamaddonfard
doaj  

Continuous subcutaneous apomorphine monotherapy in Parkinson’s disease

Annals of Agricultural and Environmental Medicine, 2019
Introduction and objective Continuous subcutaneous apomorphine (APO) treatment is one of the 3 therapeutic options for advanced Parkinson’s disease (PD), in addition to deep brain stimulation (DBS) and intrajejunal levodopa.
Ewa Papuć, Olga Trzciniecka, Konrad Rejdak   +2 more
doaj   +1 more source

Serotonin system implication in L-DOPA-induced dyskinesia: from animal models to clinical investigations [PDF]

, 2014
In the recent years, the serotonin system has emerged as a key player in the induction of l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease. In fact, serotonin neurons possess the enzymatic machinery able to convert exogenous l-DOPA
CARTA, MANOLO, TRONCI, ELISABETTA
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The Role of Genetic Data in Selecting Device-Aided Therapies in Patients With Advanced Parkinson’s Disease: A Mini-Review

Frontiers in Aging Neuroscience, 2022
Parkinson’s disease (PD) is a common neurodegenerative disease. At present, 5–10% of PD patients are found to have monogenic form of the disease. Each genetic mutation has its own unique clinical features and disease trajectory.
Germaine Hiu-Fai Chan
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Dopamine Function and Hypothalamic-Pituitary-Thyroid Axis Activity in Major Depressed Patients with Suicidal Behavior

Brain Sciences, 2022
Involvement of the dopaminergic (DA) and hypothalamic-pituitary-thyroid (HPT) systems in suicidal behavior is still poorly understood. We assessed multihormonal responses to apomorphine (APO; a short acting DA receptor agonist) and 8 AM and 11 PM ...
Fabrice Duval, Marie-Claude Mokrani, Vlad Danila, Alexis Erb, Felix Gonzalez Lopera, Mihaela Tomsa   +5 more
doaj   +1 more source