Results 31 to 40 of about 13,147 (207)

Night-Time Apomorphine Infusion: Who Are the Best Candidates? [PDF]

, 2023
International audienceBackground: We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night-time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's ...
Landragin, Nicolas, Mathieu Anheim, Drapier, Sophie, Anne‐Gaëlle Corbillé, Aerts, Cécile, Smaranda Leu‐Semenescu, Sophie Drapier, Marie Vidailhet, Castelnovo, Giovanni, Beatriz Abril, Dodet, Pauline, Pauline Dodet, Emmanuel Roze, Valérie Cochen De Cock, Laurène Leclair‐Visonneau, Cécile Aerts, Leclair-Visonneau, Laurène, Giovanni Castelnovo, Anheim, Mathieu, Roze, Emmanuel, Leu-Semenescu, Smaranda, Abril, Beatriz, Nicolas Landragin, Hélène Olivet, Mohamed Doulazmi, de Cock, Valérie Cochen, Isabelle Arnulf, Vidailhet, Marie, Doulazmi, Mohamed, Arnulf, Isabelle, Olivet, Hélène, Corbillé, Anne Gaelle   +31 more
core   +1 more source

The Role of Genetic Data in Selecting Device-Aided Therapies in Patients With Advanced Parkinson’s Disease: A Mini-Review

Frontiers in Aging Neuroscience, 2022
Parkinson’s disease (PD) is a common neurodegenerative disease. At present, 5–10% of PD patients are found to have monogenic form of the disease. Each genetic mutation has its own unique clinical features and disease trajectory.
Germaine Hiu-Fai Chan
doaj   +1 more source

Apomorphine formulation may influence subcutaneous complications from continuous subcutaneous apomorphine infusion in Parkinsons disease [PDF]

, 2020
Continuous subcutaneous (s.c.) apomorphine infusion is an effective therapy for Parkinsons disease (PD), but a limitation is the formation of troublesome s.c. nodules. Various chemically non-identical apomorphine formulations are available.
Sjöström, Anne-Christine,, Dizdar, Nil,, Kristianstad University., Sjöström, Anne-Christine, Höglund, Arja, Johansson, Eva-Lena,, Löwed, Berit,, Dizdar, Nil, Höglund, Arja,, Rådberg, Johan,, Lundgren, Margareth,, Bergquist, Filip,, Löwed, Berit, Rådberg, Johan, Hagell, Peter, Willows, Thomas,, Johansson, Anders, Hellqvist, Carina, Hagell, Peter,, Hellqvist, Carina,, Karlberg, Carina,, Johansson, Anders,, Johansson, Eva-Lena, Karlberg, Carina, Bergquist, Filip, Lundgren, Margareth, Willows, Thomas   +26 more
core   +1 more source

Continuous Apomorphine Infusion in Multiple System Atrophy Real‐World Insights From a French Nationwide Retrospective Cohort

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Continuous subcutaneous apomorphine infusion (CSAI) is effective in Parkinson's disease but has not been evaluated in multiple system atrophy (MSA). Objective To assess the 6‐month efficacy and tolerability of CSAI in MSA patients. Methods French multicenter retrospective registry‐based analysis of CSAI use in MSA.
Simon Lamy, Frederique Leh, Alexandra Foubert‐Samier, Soizic Leguy Bonnet, Guillaume Baille, Margherita Fabbri, Margaux Dunoyer, Lise Mantisi, Caroline Giordana, Anaïs El Ouartassi, Olivier Rascol, Wassilios G. Meissner, David Bendetowicz, Marie Vanel, David Grabli, Fabienne Ory‐Magne, Sophie Drapier   +16 more
wiley   +1 more source

Increased Serum Lithium Level due to Mild to Moderate damage to Dopaminergic Neurons of the Substantia Nigra, Evidence from Animal Model of Parkinson’s Disease induced by 6-Hydoxydopamine

مجله علمی دانشگاه علوم پزشکی کردستان, 2022
Background and Aim. It has been reported that lithium (Li) has neuroprotective effects in neurodegenerative diseases. In this study, we investigated the association between serum Li level and Parkinson’s disease induced by 6-hydroxypapamine (6-OHDA) in ...
Mohammad Hossein Esmaeili, Hashem Haghdoost-Yazdi, Milad Mazaheri   +2 more
doaj  

Dopamine Function and Hypothalamic-Pituitary-Thyroid Axis Activity in Major Depressed Patients with Suicidal Behavior

Brain Sciences, 2022
Involvement of the dopaminergic (DA) and hypothalamic-pituitary-thyroid (HPT) systems in suicidal behavior is still poorly understood. We assessed multihormonal responses to apomorphine (APO; a short acting DA receptor agonist) and 8 AM and 11 PM ...
Fabrice Duval, Marie-Claude Mokrani, Vlad Danila, Alexis Erb, Felix Gonzalez Lopera, Mihaela Tomsa   +5 more
doaj   +1 more source

Attenuation of age-related cognitive decline and memory deficits through apomorphine administration

Pakistan Journal of Pharmaceutical Sciences
Oxidative stress, stemming from heightened production of reactive oxygen species and free radicals, significantly contributes to the aging process. Apomorphine emerges as a pivotal medication for managing Alzheimer’s, Parkinson’s, and other age-related ...
Huma Ikram, Rumaisa Zakir, Darakhshan Jabeen Haleem, Karachi, Pakistan   +4 more
doaj   +1 more source

Drugs to the Rescue: Comparison of On-Demand Therapies for OFF Symptoms in Parkinson’s Disease

Journal of Parkinson’s Disease, 2023
Patients with Parkinson’s disease often suffer from OFF symptoms disrupting their daily routines and adding to disabilities. Despite polypharmacy and adjustments to medication schedules, they often do not experience consistent relief from their motor ...
Alfonso E. Martinez-Nunez, Peter A. LeWitt   +1 more
doaj   +1 more source

Effects of apomorphine on orienting reaction in the rat [PDF]

, 2009
Aim of the research was to study the possible relationship between rapid apomorphine-induced modifications of midbrain dopaminergic neuron activity and rapid modifications of a motor response triggered by sensory stimuli (sensory-motor integration ...
CRESCIMANNO, Giuseppe, SORBERA, Filippina, CASARRUBEA, Maurizio   +2 more
core  

Efficacy of Intranasal Apomorphine in Parkinson's Disease [PDF]

, 1995
Objective: To suggest that intranasal delivery may offer an effective alternative to subcutaneous injection of apomorphine. Methods: Four patients (3 men, 1 woman) with idiopathic Parkinson's disease, with disabling “on-off” fluctuations in motor ...
Francisco M García, Angel P Sempere, Jacinto Duarte, Maria Dolores Ruiz, Maria Angeles San Jose, Luis Erick Clavería, Francisco Coria, Angel L Mataix   +7 more
core   +1 more source