Results 21 to 30 of about 14,827 (208)

Apomorphine Suppresses the Progression of Steatohepatitis by Inhibiting Ferroptosis

Antioxidants
The role of ferroptosis in steatohepatitis development is largely unknown. We investigated (1) whether hepatocyte ferroptosis occurs in a gene-modified steatohepatitis model without modifying dietary components, (2) whether ferroptosis occurs at an early
Hiroshi Maeda, Kouichi Miura, Kenichi Aizawa, Oyunjargal Bat-Erdene, Miho Sashikawa-Kimura, Eri Noguchi, Masako Watanabe, Naoya Yamada, Hitoshi Osaka, Naoki Morimoto, Hironori Yamamoto   +10 more
doaj   +2 more sources

Inhaled Levodopa for the Management of OFF Episodes in Patients with Parkinson’s Disease: A Network Meta-analysis [PDF]

Neurology and Therapy
Introduction In the course of their disease, most patients with Parkinson’s disease (PD) will experience OFF episodes, during which symptoms worsen despite symptomatic treatment.
Omar Madani, Chetan Mistry, Rushab Shah, Grace Chattey, Leandro Guerra Primo, Hanne C. Gadeberg, Stefano Perni, Ubong Silas, Carmen Walter, Georg-Alexander Pietsch, Günter Höglinger   +10 more
doaj   +2 more sources

Intermittent Subcutaneous Injections of Apomorphine in Parkinson’s Disease

, 2022
The intermittent subcutaneous injection of apomorphine is highly effective in the management of motor and non-motor symptoms of Parkinson's disease. Although it has been shown that apomorphine injection can be safely used in selected cases at all stages ...
Nazli Durmaz Celik, Murat Gültekin, YILMAZ, REZZAK, Gül Yalçin Çakmakli, YALÇIN ÇAKMAKLI, GÜL, Celik, Nazli Durmaz, Nazlı Durmaz Çelik, Bedia Samanci, Rezzak Yilmaz, GÜLTEKİN, MURAT, CEYLAN, Mustafa, SAMANCI, Bedia, Mustafa Ceylan, Çelik, Nazlı Durmaz, ERZURUMLUOĞLU GÖKALP, EBRU   +14 more
core   +1 more source

Acute lethargy after abrupt apomorphine withdrawal in Parkinson's disease [PDF]

, 2019
- Continuous apomorphine infusion represents an established treatment for advanced Parkinson's Disease (PD). - Acute lethargy was repeatedly observed following abrupt apomorphine withdrawal. - Profound lethargy was not associated to severe akinetic
Krack, Paul, Moro, Elena, Fraix, Valérie, Cavallieri, Francesco, Meoni, Sara, Castrioto, Anna, Moro E, Krack P, Meoni S, Cavallieri F, Fraix V, Castrioto A   +11 more
core   +1 more source

Motor Evoked Potentials Improve Targeting in Deep Brain Stimulation Surgery

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives One of the main challenges posed by the surgical deep brain stimulation (DBS) procedure is the successful targeting of the structures of interest and avoidance of side effects, especially in asleep surgery. Here, intraoperative motor evoked potentials (MEPs) might serve as tool to identify the pyramidal tract.
Petyo Nikolov, Verena Heil, Christian J. Hartmann, Nikola Ivanov, Philipp J. Slotty, Jan Vesper, Alfons Schnitzler, Stefan Jun Groiss   +7 more
wiley   +1 more source

Apomorphine: The initial indian experience in relation to response tests and pumps

Annals of Indian Academy of Neurology, 2020
Background: Apomorphine is an option for continuous dopaminergic therapy in Parkinson's disease (PD). However, its effects in varied populations are limited due to its availability.
L K Prashanth, R Jaychandran, Raghavendra Seetharam, Rajesh B Iyer   +3 more
doaj   +1 more source

Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq

Antibiotics, 2021
Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance
Florian Turbant, David Partouche, Omar El Hamoui, Sylvain Trépout, Théa Legoubey, Frank Wien, Véronique Arluison   +6 more
doaj   +1 more source

Apomorphine in the Treatment of Parkinson's Disease

, 2021
Apomorphine is a dopamine agonist used in the treatment of some motor and non-motor complications during Parkinson's disease, which could be administered as an intermittent or continuous infusion.
ÖZKAYNAK, SEHÜR SİBEL, AKBOSTANCI, MUHİTTİN CENK, DOĞU, OKAN, ÇAKMUR, RAİF, Hanagasi, Hasmet, ÖZKAN, SERHAT, ELİBOL, BÜLENT, Erer, Sevda, Sehür Sibel Özkaynak, Okan Doğu, Sevda Erer, Raif Çakmur, Haşmet Hanağası, Bülent Elibol, Muhittin Cenk Akbostancı, Serhat Özkan   +15 more
core   +1 more source

Low–dose apomorphine challenge in tardive akathisia [PDF]

, 1993
We challenged seven tardive akathisia patients with low-dose apomorphine (0.01 mg/kg) SC and placebo in a double-blind, random design. Apomorphine caused a significantly greater reduction in the objective (movement) but not the subjective (distress ...
Loneragan, C, Sachdev, P ; https://orcid.org/   +1 more
core   +1 more source

Inhaled Apomorphine in Patients with ‘on-off’ Fluctuations: A Randomized, Double-blind, Placebo-controlled, Clinic and Home Based, Parallel-group Study

Journal of Parkinson’s Disease, 2013
Background: In later stages of Parkinson's disease, treatment of ‘off’ periods with subcutaneous apomorphine is helpful but requires injection; inhaled apomorphine would be potentially more convenient. Objectives: To identify optimal efficacy, safety and
Katherine A. Grosset, Naveed Malek, Frazer Morgan, Donald G. Grosset   +3 more
doaj   +1 more source